Limits...
Epigenetic signatures of internal migration in Italy.

Campanella G, Polidoro S, Di Gaetano C, Fiorito G, Guarrera S, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Elliott P, Matullo G, Chadeau-Hyam M, Vineis P - Int J Epidemiol (2014)

Bottom Line: Using genome-wide DNA methylation profiles from more than 1000 Italian participants, we conducted an epigenome-wide association study (EWAS) to identify differences between south-to-north migrants and their origin (southern natives) and host (north-western natives) populations.We identified several differentially methylated CpG loci, in particular when comparing south-to-north migrants with north-western natives.Our study is the first large agnostic investigation of DNA methylation changes linked to migratory processes, and shows the potential of EWAS to investigate their biological effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Imperial College London, London, UK,Human Genetics Foundation (HuGeF), Turin, Italy, Department of Medical Sciences, University of Turin, Turin, Italy, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy, Istituto per lo Studio e la Prevenzione Oncologica (ISPO Toscana), Florence, Italy, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy, Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Turin, Italy Cancer Registry and Histopathology Unit, Azienda Ospedaliera 'Civile - M. P. Arezzo', Ragusa, Italy and MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.

No MeSH data available.


Related in: MedlinePlus

Signed Manhattan plot for the EWAS comparing south-to-north migrants with: (A) the origin population (southern natives); (B) the host population (north-western natives).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4588856&req=5

dyu198-F1: Signed Manhattan plot for the EWAS comparing south-to-north migrants with: (A) the origin population (southern natives); (B) the host population (north-western natives).

Mentions: As illustrated in Figure 1A, the EWAS identified 20 differentially methylated CpG loci in south-to-north migrants with respect to the origin population (southern natives). Two probe sequences were ambiguously aligned to the reference human genome, and genetic variations were found in the vicinity of nine candidate CpG loci. A total of nine CpG loci were left for further consideration, of which none survived the adjustment for dietary and lifestyle factors (Supplementary Table 1, available as Supplementary data at IJE online).Figure 1.


Epigenetic signatures of internal migration in Italy.

Campanella G, Polidoro S, Di Gaetano C, Fiorito G, Guarrera S, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Elliott P, Matullo G, Chadeau-Hyam M, Vineis P - Int J Epidemiol (2014)

Signed Manhattan plot for the EWAS comparing south-to-north migrants with: (A) the origin population (southern natives); (B) the host population (north-western natives).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588856&req=5

dyu198-F1: Signed Manhattan plot for the EWAS comparing south-to-north migrants with: (A) the origin population (southern natives); (B) the host population (north-western natives).
Mentions: As illustrated in Figure 1A, the EWAS identified 20 differentially methylated CpG loci in south-to-north migrants with respect to the origin population (southern natives). Two probe sequences were ambiguously aligned to the reference human genome, and genetic variations were found in the vicinity of nine candidate CpG loci. A total of nine CpG loci were left for further consideration, of which none survived the adjustment for dietary and lifestyle factors (Supplementary Table 1, available as Supplementary data at IJE online).Figure 1.

Bottom Line: Using genome-wide DNA methylation profiles from more than 1000 Italian participants, we conducted an epigenome-wide association study (EWAS) to identify differences between south-to-north migrants and their origin (southern natives) and host (north-western natives) populations.We identified several differentially methylated CpG loci, in particular when comparing south-to-north migrants with north-western natives.Our study is the first large agnostic investigation of DNA methylation changes linked to migratory processes, and shows the potential of EWAS to investigate their biological effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Imperial College London, London, UK,Human Genetics Foundation (HuGeF), Turin, Italy, Department of Medical Sciences, University of Turin, Turin, Italy, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy, Istituto per lo Studio e la Prevenzione Oncologica (ISPO Toscana), Florence, Italy, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy, Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Turin, Italy Cancer Registry and Histopathology Unit, Azienda Ospedaliera 'Civile - M. P. Arezzo', Ragusa, Italy and MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.

No MeSH data available.


Related in: MedlinePlus