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Prenatal diagnosis of congenital mesoblastic nephroma.

Do AY, Kim JS, Choi SJ, Oh SY, Roh CR, Kim JH - Obstet Gynecol Sci (2015)

Bottom Line: At 35 weeks of gestation, the patient was admitted with preterm premature rupture of membranes and the baby was delivered vaginally.Postnatal ultrasonography and computed tomography showed a heterogeneous solid mass on the right kidney.The newborn was discharged in good condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Congenital mesoblastic nephroma is a rare renal tumor that is diagnosed during pregnancy and is associated with polyhydramnios, prematurity, and neonatal hypertension. Differential diagnoses include Wilms tumor, adrenal neuroblastoma, and other abdominal tumors. We report a case of congenital mesoblastic nephroma detected by prenatal ultrasonography as a large fetal renal mass with polyhydramnios at 32 weeks of gestation. Ultrasonography showed a 6×6-cm complex, solid, hyperechoic, round mass in the right kidney. At 35 weeks of gestation, the patient was admitted with preterm premature rupture of membranes and the baby was delivered vaginally. Postnatal ultrasonography and computed tomography showed a heterogeneous solid mass on the right kidney. At the end of the first week of life, a right nephrectomy was performed and subsequent pathological examination confirmed a cellular variant of congenital mesoblastic nephroma with a high mitotic count. Postoperative adjuvant chemotherapy was administered. The newborn was discharged in good condition.

No MeSH data available.


Related in: MedlinePlus

Nephrectomy: cut sections and pathologic findings. (A) The mass originated from the lower pole of the right kidney. The cut surface is yellowish white with a whirling pattern. Lower, mass; upper, normal. (B) Hematoxylin and eosin stain, ×100. Microscopically, the mass is composed of intersecting bundles of spindle cells with frequent mitoses (inset).
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Figure 2: Nephrectomy: cut sections and pathologic findings. (A) The mass originated from the lower pole of the right kidney. The cut surface is yellowish white with a whirling pattern. Lower, mass; upper, normal. (B) Hematoxylin and eosin stain, ×100. Microscopically, the mass is composed of intersecting bundles of spindle cells with frequent mitoses (inset).

Mentions: Three days after birth, the neonate underwent a nephrectomy by a pediatric surgeon. The renal mass (6.5×5.0×5.0 cm) originated from the lower pole of the right kidney and was confined to the kidney (Fig. 2). Inspection of the cut section revealed that the mass was round, solid, and well circumscribed, and the cut surface was yellowish white with a whirling pattern. Microscopic examination showed that the mass was composed of intersecting bundles of spindle cells with frequent mitoses (>20/10 high power field) (Fig. 2B), and was diagnosed as a cellular variant of mesoblastic nephroma. The baby was refered to pediatrics and has undergone six cycles of chemotherapy with vincristine (0.1 to 0.15 mg), dactinomycin (0.02 to 0.04 mg), and cyclophosphamide (35 to 50 mg). Baby experienced mild nausea, vomit, and fever. But, there were no any other serious side effects. Currently, the baby is 8 months old, with no signs of tumor recurrence on CT.


Prenatal diagnosis of congenital mesoblastic nephroma.

Do AY, Kim JS, Choi SJ, Oh SY, Roh CR, Kim JH - Obstet Gynecol Sci (2015)

Nephrectomy: cut sections and pathologic findings. (A) The mass originated from the lower pole of the right kidney. The cut surface is yellowish white with a whirling pattern. Lower, mass; upper, normal. (B) Hematoxylin and eosin stain, ×100. Microscopically, the mass is composed of intersecting bundles of spindle cells with frequent mitoses (inset).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588847&req=5

Figure 2: Nephrectomy: cut sections and pathologic findings. (A) The mass originated from the lower pole of the right kidney. The cut surface is yellowish white with a whirling pattern. Lower, mass; upper, normal. (B) Hematoxylin and eosin stain, ×100. Microscopically, the mass is composed of intersecting bundles of spindle cells with frequent mitoses (inset).
Mentions: Three days after birth, the neonate underwent a nephrectomy by a pediatric surgeon. The renal mass (6.5×5.0×5.0 cm) originated from the lower pole of the right kidney and was confined to the kidney (Fig. 2). Inspection of the cut section revealed that the mass was round, solid, and well circumscribed, and the cut surface was yellowish white with a whirling pattern. Microscopic examination showed that the mass was composed of intersecting bundles of spindle cells with frequent mitoses (>20/10 high power field) (Fig. 2B), and was diagnosed as a cellular variant of mesoblastic nephroma. The baby was refered to pediatrics and has undergone six cycles of chemotherapy with vincristine (0.1 to 0.15 mg), dactinomycin (0.02 to 0.04 mg), and cyclophosphamide (35 to 50 mg). Baby experienced mild nausea, vomit, and fever. But, there were no any other serious side effects. Currently, the baby is 8 months old, with no signs of tumor recurrence on CT.

Bottom Line: At 35 weeks of gestation, the patient was admitted with preterm premature rupture of membranes and the baby was delivered vaginally.Postnatal ultrasonography and computed tomography showed a heterogeneous solid mass on the right kidney.The newborn was discharged in good condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Congenital mesoblastic nephroma is a rare renal tumor that is diagnosed during pregnancy and is associated with polyhydramnios, prematurity, and neonatal hypertension. Differential diagnoses include Wilms tumor, adrenal neuroblastoma, and other abdominal tumors. We report a case of congenital mesoblastic nephroma detected by prenatal ultrasonography as a large fetal renal mass with polyhydramnios at 32 weeks of gestation. Ultrasonography showed a 6×6-cm complex, solid, hyperechoic, round mass in the right kidney. At 35 weeks of gestation, the patient was admitted with preterm premature rupture of membranes and the baby was delivered vaginally. Postnatal ultrasonography and computed tomography showed a heterogeneous solid mass on the right kidney. At the end of the first week of life, a right nephrectomy was performed and subsequent pathological examination confirmed a cellular variant of congenital mesoblastic nephroma with a high mitotic count. Postoperative adjuvant chemotherapy was administered. The newborn was discharged in good condition.

No MeSH data available.


Related in: MedlinePlus