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Prediction of lymph node metastasis in patients with apparent early endometrial cancer.

Son JH, Kong TW, Kim SH, Paek J, Chang SJ, Lee EJ, Ryu HS - Obstet Gynecol Sci (2015)

Bottom Line: Clinical and pathological data were obtained from medical records and statistically analyzed.Of the 142 patients, 127 patients (89.4%) presented with stage 1A, 8 (5.6%) with stage IB, 3 (2.1%) with stage II, and 4 (2.8%) with stage III disease.Lymph node metastasis was only found in patients with preoperative grade 2 tumors or a high serum CA-125 level.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objective: The purpose of this study is to investigate the incidence of lymph node metastasis in early endometrial cancer patients and to evaluate preoperative clinicopathological factors predicting lymph node metastasis.

Methods: We identified 142 patients with endometrial cancer between January 2000 and February 2013. All patients demonstrated endometrioid adenocarcinoma with grade 1 or 2 on preoperative endometrial biopsy. Preoperative magnetic resonance imaging showed that tumors were confined to the uterine corpus with superficial myometrial invasion (less than 50%), and there were no lymph nodes enlargements. All patients had complete staging procedures and were surgically staged according to the 2009 FIGO (International Federation of Gynecology and Obstetrics) staging system. Clinical and pathological data were obtained from medical records and statistically analyzed.

Results: Of the 142 patients, 127 patients (89.4%) presented with stage 1A, 8 (5.6%) with stage IB, 3 (2.1%) with stage II, and 4 (2.8%) with stage III disease. Three patients (2.1%) had lymph node metastasis-2 IIIC1 and 1 IIIC2 disease. Age, preoperative tumor grade, and myometrial invasion less than 50% on preoperative MRI were not associated with lymph node metastasis. A high preoperative serum CA-125 level (>35 IU/mL) was a statistically significant factor for predicting lymph node metastasis on univariate and multivariate analyses. Lymph node metastasis was only found in patients with preoperative grade 2 tumors or a high serum CA-125 level.

Conclusion: Preoperative tumor grade and serum CA-125 level can predict lymph node metastasis in apparent early endometrial cancer patients.

No MeSH data available.


Related in: MedlinePlus

Inclusion criteria. MRI, magnetic resonance imaging; Preop, preoperative; LN, lymph node.
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Figure 1: Inclusion criteria. MRI, magnetic resonance imaging; Preop, preoperative; LN, lymph node.

Mentions: We retrospectively reviewed all patients with endometrial cancer treated between January 2000 and February 2013 in the Department of Obstetrics and Gynecology, Ajou University. Using inclusion criteria of histologically confirmed endometrial adenocarcinoma, preoperative grade 1-2 on endometrial biopsy and less than 50% myometrial invasion without lymph node enlargement on preoperative magnetic resonance imaging (MRI), 142 patients were identified during the study period (Fig. 1).


Prediction of lymph node metastasis in patients with apparent early endometrial cancer.

Son JH, Kong TW, Kim SH, Paek J, Chang SJ, Lee EJ, Ryu HS - Obstet Gynecol Sci (2015)

Inclusion criteria. MRI, magnetic resonance imaging; Preop, preoperative; LN, lymph node.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588843&req=5

Figure 1: Inclusion criteria. MRI, magnetic resonance imaging; Preop, preoperative; LN, lymph node.
Mentions: We retrospectively reviewed all patients with endometrial cancer treated between January 2000 and February 2013 in the Department of Obstetrics and Gynecology, Ajou University. Using inclusion criteria of histologically confirmed endometrial adenocarcinoma, preoperative grade 1-2 on endometrial biopsy and less than 50% myometrial invasion without lymph node enlargement on preoperative magnetic resonance imaging (MRI), 142 patients were identified during the study period (Fig. 1).

Bottom Line: Clinical and pathological data were obtained from medical records and statistically analyzed.Of the 142 patients, 127 patients (89.4%) presented with stage 1A, 8 (5.6%) with stage IB, 3 (2.1%) with stage II, and 4 (2.8%) with stage III disease.Lymph node metastasis was only found in patients with preoperative grade 2 tumors or a high serum CA-125 level.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objective: The purpose of this study is to investigate the incidence of lymph node metastasis in early endometrial cancer patients and to evaluate preoperative clinicopathological factors predicting lymph node metastasis.

Methods: We identified 142 patients with endometrial cancer between January 2000 and February 2013. All patients demonstrated endometrioid adenocarcinoma with grade 1 or 2 on preoperative endometrial biopsy. Preoperative magnetic resonance imaging showed that tumors were confined to the uterine corpus with superficial myometrial invasion (less than 50%), and there were no lymph nodes enlargements. All patients had complete staging procedures and were surgically staged according to the 2009 FIGO (International Federation of Gynecology and Obstetrics) staging system. Clinical and pathological data were obtained from medical records and statistically analyzed.

Results: Of the 142 patients, 127 patients (89.4%) presented with stage 1A, 8 (5.6%) with stage IB, 3 (2.1%) with stage II, and 4 (2.8%) with stage III disease. Three patients (2.1%) had lymph node metastasis-2 IIIC1 and 1 IIIC2 disease. Age, preoperative tumor grade, and myometrial invasion less than 50% on preoperative MRI were not associated with lymph node metastasis. A high preoperative serum CA-125 level (>35 IU/mL) was a statistically significant factor for predicting lymph node metastasis on univariate and multivariate analyses. Lymph node metastasis was only found in patients with preoperative grade 2 tumors or a high serum CA-125 level.

Conclusion: Preoperative tumor grade and serum CA-125 level can predict lymph node metastasis in apparent early endometrial cancer patients.

No MeSH data available.


Related in: MedlinePlus