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Type and amount of dietary protein in the treatment of metabolic syndrome: a randomized controlled trial.

Hill AM, Harris Jackson KA, Roussell MA, West SG, Kris-Etherton PM - Am. J. Clin. Nutr. (2015)

Bottom Line: Diets were compared across 3 phases of energy balance: 5 wk of controlled (all foods provided) weight maintenance (WM), 6 wk of controlled weight loss (minimum 500-kcal/d deficit) including exercise (WL), and 12 wk of prescribed, free-living weight loss (FL).After WM, all groups had a MetS prevalence of 80-90% [healthy American diet (HAD) compared with WM, P = NS], which decreased to 50-60% after WL and was maintained through FL (HAD, WM vs WL, FL, P < 0.01).Weight loss was the primary modifier of MetS resolution in our study population regardless of protein source or amount.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy & Medical Sciences, University of South Australia, Adelaide, Australia; and Department of Nutritional Sciences and.

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Related in: MedlinePlus

Participant flow diagram. aPartial data, completed weight-maintenance and weight-loss phases. bPartial data, completed weight-maintenance phase. BP, blood pressure; BOLD, Beef in an Optimal Lean Diet; BOLD+, Beef in an Optimal Lean Diet Plus; HAD, healthy American diet; M-DASH, modified Dietary Approaches to Stop Hypertension.
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fig1: Participant flow diagram. aPartial data, completed weight-maintenance and weight-loss phases. bPartial data, completed weight-maintenance phase. BP, blood pressure; BOLD, Beef in an Optimal Lean Diet; BOLD+, Beef in an Optimal Lean Diet Plus; HAD, healthy American diet; M-DASH, modified Dietary Approaches to Stop Hypertension.

Mentions: Recruitment of study participants took 2.5 y because of the strict study eligibility criteria. Of the 572 respondents, 180 (31%) completed the informed consent and were screened at the clinic for eligibility. Between November 2008 and March 2011, 73 (13%) were enrolled and began the HAD diet (Figure 1). Seven participants did not complete the HAD run-in diet. The remaining 66 individuals were randomly allocated, after which 7 participants did not complete the study because of an inability to comply with the diet (n = 3), unrelated illness (n = 2), relocation (n = 1), and scheduling conflicts (n = 1). Of these 7 participants, 3 completed an entire feeding phase before dropping out, and their data are included in the final analysis (n = 62). The retention rates for the 3 diet groups were similar: 95% (n = 20/21) for BOLD, 95% (n = 21/22) for BOLD+, and 91% (n = 21/23) for M-DASH. There were no differences among groups at screening (Table 4). One participant (M-DASH) was taken off BP medications before starting the study and maintained acceptable BP to remain in the study; 7 participants (BOLD, n = 2; BOLD+, n = 2; M-DASH, n = 3) were taking BP medications during the study. Because of difficulties in recruitment for a 6-mo dietary intervention study, recruitment goals were not met.


Type and amount of dietary protein in the treatment of metabolic syndrome: a randomized controlled trial.

Hill AM, Harris Jackson KA, Roussell MA, West SG, Kris-Etherton PM - Am. J. Clin. Nutr. (2015)

Participant flow diagram. aPartial data, completed weight-maintenance and weight-loss phases. bPartial data, completed weight-maintenance phase. BP, blood pressure; BOLD, Beef in an Optimal Lean Diet; BOLD+, Beef in an Optimal Lean Diet Plus; HAD, healthy American diet; M-DASH, modified Dietary Approaches to Stop Hypertension.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588738&req=5

fig1: Participant flow diagram. aPartial data, completed weight-maintenance and weight-loss phases. bPartial data, completed weight-maintenance phase. BP, blood pressure; BOLD, Beef in an Optimal Lean Diet; BOLD+, Beef in an Optimal Lean Diet Plus; HAD, healthy American diet; M-DASH, modified Dietary Approaches to Stop Hypertension.
Mentions: Recruitment of study participants took 2.5 y because of the strict study eligibility criteria. Of the 572 respondents, 180 (31%) completed the informed consent and were screened at the clinic for eligibility. Between November 2008 and March 2011, 73 (13%) were enrolled and began the HAD diet (Figure 1). Seven participants did not complete the HAD run-in diet. The remaining 66 individuals were randomly allocated, after which 7 participants did not complete the study because of an inability to comply with the diet (n = 3), unrelated illness (n = 2), relocation (n = 1), and scheduling conflicts (n = 1). Of these 7 participants, 3 completed an entire feeding phase before dropping out, and their data are included in the final analysis (n = 62). The retention rates for the 3 diet groups were similar: 95% (n = 20/21) for BOLD, 95% (n = 21/22) for BOLD+, and 91% (n = 21/23) for M-DASH. There were no differences among groups at screening (Table 4). One participant (M-DASH) was taken off BP medications before starting the study and maintained acceptable BP to remain in the study; 7 participants (BOLD, n = 2; BOLD+, n = 2; M-DASH, n = 3) were taking BP medications during the study. Because of difficulties in recruitment for a 6-mo dietary intervention study, recruitment goals were not met.

Bottom Line: Diets were compared across 3 phases of energy balance: 5 wk of controlled (all foods provided) weight maintenance (WM), 6 wk of controlled weight loss (minimum 500-kcal/d deficit) including exercise (WL), and 12 wk of prescribed, free-living weight loss (FL).After WM, all groups had a MetS prevalence of 80-90% [healthy American diet (HAD) compared with WM, P = NS], which decreased to 50-60% after WL and was maintained through FL (HAD, WM vs WL, FL, P < 0.01).Weight loss was the primary modifier of MetS resolution in our study population regardless of protein source or amount.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy & Medical Sciences, University of South Australia, Adelaide, Australia; and Department of Nutritional Sciences and.

Show MeSH
Related in: MedlinePlus