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The Vallecas Project: A Cohort to Identify Early Markers and Mechanisms of Alzheimer's Disease.

Olazarán J, Valentí M, Frades B, Zea-Sevilla MA, Ávila-Villanueva M, Fernández-Blázquez MÁ, Calero M, Dobato JL, Hernández-Tamames JA, León-Salas B, Agüera-Ortiz L, López-Álvarez J, Larrañaga P, Bielza C, Álvarez-Linera J, Martínez-Martín P - Front Aging Neurosci (2015)

Bottom Line: Cognitive diagnoses at inclusion were as follows: normal cognition 93.0% and mild cognitive impairment (MCI) 7.0% (3.1% amnestic MCI, 0.1% non-amnestic MCI, 3.8% mixed MCI).The cohort is being followed up annually for 4 years after the baseline.We have established a valuable homogeneous single-center cohort which, by identifying groups of variables associated with high risk of MCI or dementia conversion, should help to clarify the early physiopathological mechanisms of AD and should provide avenues for prompt diagnosis and AD prevention.

View Article: PubMed Central - PubMed

Affiliation: Gregorio Marañón University Hospital , Madrid , Spain.

ABSTRACT

Introduction: Alzheimer's disease (AD) is a major threat for the well-being of an increasingly aged world population. The physiopathological mechanisms of late-onset AD are multiple, possibly heterogeneous, and not well understood. Different combinations of variables from several domains (i.e., clinical, neuropsychological, structural, and biochemical markers) may predict dementia conversion, according to distinct physiopathological pathways, in different groups of subjects.

Methods: We launched the Vallecas Project (VP), a cohort study of non-demented people aged 70-85, to characterize the social, clinical, neuropsychological, structural, and biochemical underpinnings of AD inception. Given the exploratory nature of the VP, multidimensional and machine learning techniques will be applied, in addition to the traditional multivariate statistical methods.

Results: A total of 1169 subjects were recruited between October 2011 and December 2013. Mean age was 74.4 years (SD 3.9), 63.5% of the subjects were women, and 17.9% of the subjects were carriers of at least one ε4 allele of the apolipoprotein E gene. Cognitive diagnoses at inclusion were as follows: normal cognition 93.0% and mild cognitive impairment (MCI) 7.0% (3.1% amnestic MCI, 0.1% non-amnestic MCI, 3.8% mixed MCI). Blood samples were obtained and stored for future determinations in 99.9% of the subjects and 3T magnetic resonance imaging study was conducted in 89.9% of the volunteers. The cohort is being followed up annually for 4 years after the baseline.

Conclusion: We have established a valuable homogeneous single-center cohort which, by identifying groups of variables associated with high risk of MCI or dementia conversion, should help to clarify the early physiopathological mechanisms of AD and should provide avenues for prompt diagnosis and AD prevention.

No MeSH data available.


Related in: MedlinePlus

Flowchart of subject recruitment and baseline cognitive diagnoses. aMCI, amnestic mild cognitive impairment (MCI); naMCI, non-amnestic MCI; mMCI, mixed (i.e., amnestic and non-amnestic) MCI; NC, normal cognition.
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Figure 2: Flowchart of subject recruitment and baseline cognitive diagnoses. aMCI, amnestic mild cognitive impairment (MCI); naMCI, non-amnestic MCI; mMCI, mixed (i.e., amnestic and non-amnestic) MCI; NC, normal cognition.

Mentions: A total of 2077 subjects contacted the study secretariat during the recruitment period (i.e., October 2011 to December 2013), but 864 of them were discarded before evaluation because they were not interested in the study or clearly met some of the study exclusion criteria (Figure 2). One of the most frequent reasons for study exclusion at that point was the presence of metallic prostheses, pacemaker, or other body metals. To circumvent that obstacle for recruitment, a paper document was designed ad hoc, which the volunteers had to provide, signed by the doctor who implanted the metal prosthesis, authorizing the performance of 3-T MRI study. However, that document was only provided in a minority of the cases. For that reasons, in order to accelerate the inclusion of subjects, the exclusion criteria of the VP were modified during the recruitment period, allowing the participation of subjects for whom MRI was not possible.


The Vallecas Project: A Cohort to Identify Early Markers and Mechanisms of Alzheimer's Disease.

Olazarán J, Valentí M, Frades B, Zea-Sevilla MA, Ávila-Villanueva M, Fernández-Blázquez MÁ, Calero M, Dobato JL, Hernández-Tamames JA, León-Salas B, Agüera-Ortiz L, López-Álvarez J, Larrañaga P, Bielza C, Álvarez-Linera J, Martínez-Martín P - Front Aging Neurosci (2015)

Flowchart of subject recruitment and baseline cognitive diagnoses. aMCI, amnestic mild cognitive impairment (MCI); naMCI, non-amnestic MCI; mMCI, mixed (i.e., amnestic and non-amnestic) MCI; NC, normal cognition.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588692&req=5

Figure 2: Flowchart of subject recruitment and baseline cognitive diagnoses. aMCI, amnestic mild cognitive impairment (MCI); naMCI, non-amnestic MCI; mMCI, mixed (i.e., amnestic and non-amnestic) MCI; NC, normal cognition.
Mentions: A total of 2077 subjects contacted the study secretariat during the recruitment period (i.e., October 2011 to December 2013), but 864 of them were discarded before evaluation because they were not interested in the study or clearly met some of the study exclusion criteria (Figure 2). One of the most frequent reasons for study exclusion at that point was the presence of metallic prostheses, pacemaker, or other body metals. To circumvent that obstacle for recruitment, a paper document was designed ad hoc, which the volunteers had to provide, signed by the doctor who implanted the metal prosthesis, authorizing the performance of 3-T MRI study. However, that document was only provided in a minority of the cases. For that reasons, in order to accelerate the inclusion of subjects, the exclusion criteria of the VP were modified during the recruitment period, allowing the participation of subjects for whom MRI was not possible.

Bottom Line: Cognitive diagnoses at inclusion were as follows: normal cognition 93.0% and mild cognitive impairment (MCI) 7.0% (3.1% amnestic MCI, 0.1% non-amnestic MCI, 3.8% mixed MCI).The cohort is being followed up annually for 4 years after the baseline.We have established a valuable homogeneous single-center cohort which, by identifying groups of variables associated with high risk of MCI or dementia conversion, should help to clarify the early physiopathological mechanisms of AD and should provide avenues for prompt diagnosis and AD prevention.

View Article: PubMed Central - PubMed

Affiliation: Gregorio Marañón University Hospital , Madrid , Spain.

ABSTRACT

Introduction: Alzheimer's disease (AD) is a major threat for the well-being of an increasingly aged world population. The physiopathological mechanisms of late-onset AD are multiple, possibly heterogeneous, and not well understood. Different combinations of variables from several domains (i.e., clinical, neuropsychological, structural, and biochemical markers) may predict dementia conversion, according to distinct physiopathological pathways, in different groups of subjects.

Methods: We launched the Vallecas Project (VP), a cohort study of non-demented people aged 70-85, to characterize the social, clinical, neuropsychological, structural, and biochemical underpinnings of AD inception. Given the exploratory nature of the VP, multidimensional and machine learning techniques will be applied, in addition to the traditional multivariate statistical methods.

Results: A total of 1169 subjects were recruited between October 2011 and December 2013. Mean age was 74.4 years (SD 3.9), 63.5% of the subjects were women, and 17.9% of the subjects were carriers of at least one ε4 allele of the apolipoprotein E gene. Cognitive diagnoses at inclusion were as follows: normal cognition 93.0% and mild cognitive impairment (MCI) 7.0% (3.1% amnestic MCI, 0.1% non-amnestic MCI, 3.8% mixed MCI). Blood samples were obtained and stored for future determinations in 99.9% of the subjects and 3T magnetic resonance imaging study was conducted in 89.9% of the volunteers. The cohort is being followed up annually for 4 years after the baseline.

Conclusion: We have established a valuable homogeneous single-center cohort which, by identifying groups of variables associated with high risk of MCI or dementia conversion, should help to clarify the early physiopathological mechanisms of AD and should provide avenues for prompt diagnosis and AD prevention.

No MeSH data available.


Related in: MedlinePlus