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The association of sleep-disordered breathing with high cerebral pulsatility might not be related to diffuse small vessel disease. A pilot study.

Castillo PR, Del Brutto OH, Andrade Mde L, Zambrano M, Nader JA - BMC Res Notes (2015)

Bottom Line: The middle cerebral artery pulsatility index was increased in persons with moderate-to-severe sleep-disordered breathing compared with persons who had none-to-mild sleep-disordered breathing (mean [SD] 1.11 [0.12] vs. 1.3 [0.23], P = .01).No significant differences were found in the prevalence of moderate-to-severe white matter hyperintensities across groups of sleep-disordered breathing (P = .40) or in the mean apnea/hypopnea index across groups of persons with none-to-mild or moderate-to-severe white matter hyperintensities (P = .16).This pilot study shows that moderate-to-severe sleep-disordered breathing correlates with cerebral pulsatility, but such association might be independent of diffuse small vessel disease.

View Article: PubMed Central - PubMed

Affiliation: Division of Sleep Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA. castillo.pablo@mayo.edu.

ABSTRACT

Background: In a population-based sampling study conducted in community-dwelling older adults living in rural Ecuador, we aimed to assess the relation among sleep-disordered breathing, cerebral pulsatility index, and diffuse small vessel disease.

Methods: Of 25 participants, 9 (36%) had moderate-to-severe sleep-disordered breathing, characterized by an apnea/hypopnea index ≥15 per hour, and 10 (40%) had moderate-to-severe white matter hyperintensities, graded according to the modified Fazekas scale. Mean (SD) pulsatility index in the middle cerebral artery was 1.18 (0.19) and positively correlated with the apnea/hypopnea index (R = .445, P = .03, [Pearson's correlation coefficient]). The middle cerebral artery pulsatility index was increased in persons with moderate-to-severe sleep-disordered breathing compared with persons who had none-to-mild sleep-disordered breathing (mean [SD] 1.11 [0.12] vs. 1.3 [0.23], P = .01). No significant differences were found in the prevalence of moderate-to-severe white matter hyperintensities across groups of sleep-disordered breathing (P = .40) or in the mean apnea/hypopnea index across groups of persons with none-to-mild or moderate-to-severe white matter hyperintensities (P = .16).

Conclusions: This pilot study shows that moderate-to-severe sleep-disordered breathing correlates with cerebral pulsatility, but such association might be independent of diffuse small vessel disease.

No MeSH data available.


Related in: MedlinePlus

Screen of the Transcranial Doppler Study Performed in a Study Participant. Image showing the parameters evaluated for each artery (in this particular image, the right middle cerebral artery)
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Fig2: Screen of the Transcranial Doppler Study Performed in a Study Participant. Image showing the parameters evaluated for each artery (in this particular image, the right middle cerebral artery)

Mentions: With the use of a SONARA portable system (VIASYS Healthcare, Inc) and a 2-MHz probe, a certified sonographer (J.A.N.) performed all TCD examinations following a well-known power motion mode Doppler/spectral TCD protocol [13]. For the present study, peak systolic velocity, end-diastolic velocity, mean flow velocity, and PI of both middle cerebral arteries (MCAs) were analyzed (Fig. 2). The latter was calculated with the Gosling equation (peak systolic velocity—end-diastolic velocity/mean flow velocity). Mean values for each of these variables were calculated through averaging both MCAs unless flows from only one artery could be evaluated because of poor insonation through the contralateral transtemporal window.Fig. 2


The association of sleep-disordered breathing with high cerebral pulsatility might not be related to diffuse small vessel disease. A pilot study.

Castillo PR, Del Brutto OH, Andrade Mde L, Zambrano M, Nader JA - BMC Res Notes (2015)

Screen of the Transcranial Doppler Study Performed in a Study Participant. Image showing the parameters evaluated for each artery (in this particular image, the right middle cerebral artery)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4588689&req=5

Fig2: Screen of the Transcranial Doppler Study Performed in a Study Participant. Image showing the parameters evaluated for each artery (in this particular image, the right middle cerebral artery)
Mentions: With the use of a SONARA portable system (VIASYS Healthcare, Inc) and a 2-MHz probe, a certified sonographer (J.A.N.) performed all TCD examinations following a well-known power motion mode Doppler/spectral TCD protocol [13]. For the present study, peak systolic velocity, end-diastolic velocity, mean flow velocity, and PI of both middle cerebral arteries (MCAs) were analyzed (Fig. 2). The latter was calculated with the Gosling equation (peak systolic velocity—end-diastolic velocity/mean flow velocity). Mean values for each of these variables were calculated through averaging both MCAs unless flows from only one artery could be evaluated because of poor insonation through the contralateral transtemporal window.Fig. 2

Bottom Line: The middle cerebral artery pulsatility index was increased in persons with moderate-to-severe sleep-disordered breathing compared with persons who had none-to-mild sleep-disordered breathing (mean [SD] 1.11 [0.12] vs. 1.3 [0.23], P = .01).No significant differences were found in the prevalence of moderate-to-severe white matter hyperintensities across groups of sleep-disordered breathing (P = .40) or in the mean apnea/hypopnea index across groups of persons with none-to-mild or moderate-to-severe white matter hyperintensities (P = .16).This pilot study shows that moderate-to-severe sleep-disordered breathing correlates with cerebral pulsatility, but such association might be independent of diffuse small vessel disease.

View Article: PubMed Central - PubMed

Affiliation: Division of Sleep Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA. castillo.pablo@mayo.edu.

ABSTRACT

Background: In a population-based sampling study conducted in community-dwelling older adults living in rural Ecuador, we aimed to assess the relation among sleep-disordered breathing, cerebral pulsatility index, and diffuse small vessel disease.

Methods: Of 25 participants, 9 (36%) had moderate-to-severe sleep-disordered breathing, characterized by an apnea/hypopnea index ≥15 per hour, and 10 (40%) had moderate-to-severe white matter hyperintensities, graded according to the modified Fazekas scale. Mean (SD) pulsatility index in the middle cerebral artery was 1.18 (0.19) and positively correlated with the apnea/hypopnea index (R = .445, P = .03, [Pearson's correlation coefficient]). The middle cerebral artery pulsatility index was increased in persons with moderate-to-severe sleep-disordered breathing compared with persons who had none-to-mild sleep-disordered breathing (mean [SD] 1.11 [0.12] vs. 1.3 [0.23], P = .01). No significant differences were found in the prevalence of moderate-to-severe white matter hyperintensities across groups of sleep-disordered breathing (P = .40) or in the mean apnea/hypopnea index across groups of persons with none-to-mild or moderate-to-severe white matter hyperintensities (P = .16).

Conclusions: This pilot study shows that moderate-to-severe sleep-disordered breathing correlates with cerebral pulsatility, but such association might be independent of diffuse small vessel disease.

No MeSH data available.


Related in: MedlinePlus