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Primary malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland.

Babinska A, Peksa R, Sworczak K - World J Surg Oncol (2015)

Bottom Line: Laboratory examinations revealed a slight increase of 24-h urine vanillylmandelic acid and 24-h urinary methanephrine excretion.Histological examination revealed two intermingled tumor cell proliferations-diffuse B cell lymphoma and pheochromocytoma.Unexpected coexistence of catecholamine-producing tumor with the other adrenal lesion can lead to serious complications of diagnosis and treatment.The adequate preparation for surgery can protect patient from threatening catecholamine crisis.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine, Medical University of Gdansk, ul. Dębinki 7, 80-288, Gdańsk, Poland. a.mail@wp.pl.

ABSTRACT
An increased number of adrenal tumors are now diagnosed due to the increased number of abdominal CT scans being performed. We present the first case of malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland. An abdominal CT scan demonstrates unilateral adrenal lesion which suggests pheochromocytoma or adrenal carcinoma. Laboratory examinations revealed a slight increase of 24-h urine vanillylmandelic acid and 24-h urinary methanephrine excretion. Histological examination revealed two intermingled tumor cell proliferations-diffuse B cell lymphoma and pheochromocytoma.Unexpected coexistence of catecholamine-producing tumor with the other adrenal lesion can lead to serious complications of diagnosis and treatment. The adequate preparation for surgery can protect patient from threatening catecholamine crisis.

No MeSH data available.


Related in: MedlinePlus

Pheochromocytoma is present on the left with a diffuse area of the right. The diffuse area is comprised predominantly of large lymphoid cells, so a separate diagnosis of DLBCL is made (a, magnification ×2). Adrenal tumor infiltrates periadrenal adipose tissue and the cortical part of kidney (b, magnification ×10)
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Fig1: Pheochromocytoma is present on the left with a diffuse area of the right. The diffuse area is comprised predominantly of large lymphoid cells, so a separate diagnosis of DLBCL is made (a, magnification ×2). Adrenal tumor infiltrates periadrenal adipose tissue and the cortical part of kidney (b, magnification ×10)

Mentions: Gross lesion found in a section of the gland consisted of two parts: gray creamy tumor which destroyed the adrenal gland and the yellowish-brown spherical focus 1.8 cm in diameter which adheres to the adrenal mass. Adrenal tumor infiltrates periadrenal adipose tissue and the cortical part of the kidney (Fig. 1).Fig. 1


Primary malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland.

Babinska A, Peksa R, Sworczak K - World J Surg Oncol (2015)

Pheochromocytoma is present on the left with a diffuse area of the right. The diffuse area is comprised predominantly of large lymphoid cells, so a separate diagnosis of DLBCL is made (a, magnification ×2). Adrenal tumor infiltrates periadrenal adipose tissue and the cortical part of kidney (b, magnification ×10)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4588683&req=5

Fig1: Pheochromocytoma is present on the left with a diffuse area of the right. The diffuse area is comprised predominantly of large lymphoid cells, so a separate diagnosis of DLBCL is made (a, magnification ×2). Adrenal tumor infiltrates periadrenal adipose tissue and the cortical part of kidney (b, magnification ×10)
Mentions: Gross lesion found in a section of the gland consisted of two parts: gray creamy tumor which destroyed the adrenal gland and the yellowish-brown spherical focus 1.8 cm in diameter which adheres to the adrenal mass. Adrenal tumor infiltrates periadrenal adipose tissue and the cortical part of the kidney (Fig. 1).Fig. 1

Bottom Line: Laboratory examinations revealed a slight increase of 24-h urine vanillylmandelic acid and 24-h urinary methanephrine excretion.Histological examination revealed two intermingled tumor cell proliferations-diffuse B cell lymphoma and pheochromocytoma.Unexpected coexistence of catecholamine-producing tumor with the other adrenal lesion can lead to serious complications of diagnosis and treatment.The adequate preparation for surgery can protect patient from threatening catecholamine crisis.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine, Medical University of Gdansk, ul. Dębinki 7, 80-288, Gdańsk, Poland. a.mail@wp.pl.

ABSTRACT
An increased number of adrenal tumors are now diagnosed due to the increased number of abdominal CT scans being performed. We present the first case of malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland. An abdominal CT scan demonstrates unilateral adrenal lesion which suggests pheochromocytoma or adrenal carcinoma. Laboratory examinations revealed a slight increase of 24-h urine vanillylmandelic acid and 24-h urinary methanephrine excretion. Histological examination revealed two intermingled tumor cell proliferations-diffuse B cell lymphoma and pheochromocytoma.Unexpected coexistence of catecholamine-producing tumor with the other adrenal lesion can lead to serious complications of diagnosis and treatment. The adequate preparation for surgery can protect patient from threatening catecholamine crisis.

No MeSH data available.


Related in: MedlinePlus