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Evidence of a dissociation pattern in default mode subnetwork functional connectivity in schizophrenia.

Wang H, Zeng LL, Chen Y, Yin H, Tan Q, Hu D - Sci Rep (2015)

Bottom Line: The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics.The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics.Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Xijing Hospital of the Fourth Military Medical University, Xi'an Shaanxi 710032, People's Republic of China.

ABSTRACT
The default mode network (DMN) is suggested to play a pivotal role in schizophrenia; however, the dissociation pattern of functional connectivity of DMN subsystems remains uncharacterized in this disease. In this study, resting-state fMRI data were acquired from 55 schizophrenic patients and 53 matched healthy controls. DMN connectivity was estimated from time courses of independent components. The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics. The increased connectivity between the lateral DMN and right control network was significantly correlated with negative and anergia factor scores in the schizophrenic patients. The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics. The altered DMN connectivity may underlie the hallucinations, delusions, thought disturbances, and negative symptoms involved in schizophrenia. Furthermore, DMN connectivity patterns could be used to differentiate patients from controls with 76.9% accuracy. These findings may shed new light on the distinct role of DMN subsystems in schizophrenia, thereby furthering our understanding of the pathophysiology of schizophrenia. Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

No MeSH data available.


Related in: MedlinePlus

The dissociation pattern of the inter-default functional connectivity within unimodal and heteromodal cortical networks (two-sample t-test, P < 0.05, uncorrected).Note that functional connectivity was significantly decreased between the lateral default mode network (DMN) and unimodal cortical networks in both non-medicated and medicated patients, while it was increased between the lateral DMN and heteromodal cortical networks in the non-medicated patients only (a). The functional connectivity between the anterior DMN and heteromodal cortical networks was significantly increased in both non-medicated and medicated patients (b). No significant difference in functional connectivity was detected between the posterior DMN and unimodal and heteromodal cortical networks (c), and no significant difference in the aforementioned functional connectivity was observed between the medicated and non-medicated patients.
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f3: The dissociation pattern of the inter-default functional connectivity within unimodal and heteromodal cortical networks (two-sample t-test, P < 0.05, uncorrected).Note that functional connectivity was significantly decreased between the lateral default mode network (DMN) and unimodal cortical networks in both non-medicated and medicated patients, while it was increased between the lateral DMN and heteromodal cortical networks in the non-medicated patients only (a). The functional connectivity between the anterior DMN and heteromodal cortical networks was significantly increased in both non-medicated and medicated patients (b). No significant difference in functional connectivity was detected between the posterior DMN and unimodal and heteromodal cortical networks (c), and no significant difference in the aforementioned functional connectivity was observed between the medicated and non-medicated patients.

Mentions: When the 14 ICNs were grouped into unimodal sensorimotor cortical networks (i.e., somatomotor, motor, auditory, and visual cortices) and heteromodal association cortical networks (i.e., default mode, precuneus, control, and attention networks)24, we observed that functional connectivity was significantly decreased between the lateral DMN and unimodal cortical networks in both non-medicated and medicated patients, while functional connectivity was significantly increased between lateral DMN and heteromodal cortical networks in non-medicated patients only (Fig. 3a, P < 0.05, uncorrected). In addition, functional connectivity between the anterior DMN and heteromodal cortical networks was significantly increased in both non-medicated and medicated patients (Fig. 3b, P < 0.05, uncorrected). No significant functional connectivity difference was detected between the posterior DMN and unimodal and heteromodal cortical networks (Fig. 3c, P < 0.05, uncorrected), and no significant difference in functional connectivity was observed between medicated and non-medicated patients (P < 0.05, uncorrected).


Evidence of a dissociation pattern in default mode subnetwork functional connectivity in schizophrenia.

Wang H, Zeng LL, Chen Y, Yin H, Tan Q, Hu D - Sci Rep (2015)

The dissociation pattern of the inter-default functional connectivity within unimodal and heteromodal cortical networks (two-sample t-test, P < 0.05, uncorrected).Note that functional connectivity was significantly decreased between the lateral default mode network (DMN) and unimodal cortical networks in both non-medicated and medicated patients, while it was increased between the lateral DMN and heteromodal cortical networks in the non-medicated patients only (a). The functional connectivity between the anterior DMN and heteromodal cortical networks was significantly increased in both non-medicated and medicated patients (b). No significant difference in functional connectivity was detected between the posterior DMN and unimodal and heteromodal cortical networks (c), and no significant difference in the aforementioned functional connectivity was observed between the medicated and non-medicated patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588504&req=5

f3: The dissociation pattern of the inter-default functional connectivity within unimodal and heteromodal cortical networks (two-sample t-test, P < 0.05, uncorrected).Note that functional connectivity was significantly decreased between the lateral default mode network (DMN) and unimodal cortical networks in both non-medicated and medicated patients, while it was increased between the lateral DMN and heteromodal cortical networks in the non-medicated patients only (a). The functional connectivity between the anterior DMN and heteromodal cortical networks was significantly increased in both non-medicated and medicated patients (b). No significant difference in functional connectivity was detected between the posterior DMN and unimodal and heteromodal cortical networks (c), and no significant difference in the aforementioned functional connectivity was observed between the medicated and non-medicated patients.
Mentions: When the 14 ICNs were grouped into unimodal sensorimotor cortical networks (i.e., somatomotor, motor, auditory, and visual cortices) and heteromodal association cortical networks (i.e., default mode, precuneus, control, and attention networks)24, we observed that functional connectivity was significantly decreased between the lateral DMN and unimodal cortical networks in both non-medicated and medicated patients, while functional connectivity was significantly increased between lateral DMN and heteromodal cortical networks in non-medicated patients only (Fig. 3a, P < 0.05, uncorrected). In addition, functional connectivity between the anterior DMN and heteromodal cortical networks was significantly increased in both non-medicated and medicated patients (Fig. 3b, P < 0.05, uncorrected). No significant functional connectivity difference was detected between the posterior DMN and unimodal and heteromodal cortical networks (Fig. 3c, P < 0.05, uncorrected), and no significant difference in functional connectivity was observed between medicated and non-medicated patients (P < 0.05, uncorrected).

Bottom Line: The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics.The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics.Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Xijing Hospital of the Fourth Military Medical University, Xi'an Shaanxi 710032, People's Republic of China.

ABSTRACT
The default mode network (DMN) is suggested to play a pivotal role in schizophrenia; however, the dissociation pattern of functional connectivity of DMN subsystems remains uncharacterized in this disease. In this study, resting-state fMRI data were acquired from 55 schizophrenic patients and 53 matched healthy controls. DMN connectivity was estimated from time courses of independent components. The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics. The increased connectivity between the lateral DMN and right control network was significantly correlated with negative and anergia factor scores in the schizophrenic patients. The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics. The altered DMN connectivity may underlie the hallucinations, delusions, thought disturbances, and negative symptoms involved in schizophrenia. Furthermore, DMN connectivity patterns could be used to differentiate patients from controls with 76.9% accuracy. These findings may shed new light on the distinct role of DMN subsystems in schizophrenia, thereby furthering our understanding of the pathophysiology of schizophrenia. Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

No MeSH data available.


Related in: MedlinePlus