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Evidence of a dissociation pattern in default mode subnetwork functional connectivity in schizophrenia.

Wang H, Zeng LL, Chen Y, Yin H, Tan Q, Hu D - Sci Rep (2015)

Bottom Line: The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics.The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics.Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Xijing Hospital of the Fourth Military Medical University, Xi'an Shaanxi 710032, People's Republic of China.

ABSTRACT
The default mode network (DMN) is suggested to play a pivotal role in schizophrenia; however, the dissociation pattern of functional connectivity of DMN subsystems remains uncharacterized in this disease. In this study, resting-state fMRI data were acquired from 55 schizophrenic patients and 53 matched healthy controls. DMN connectivity was estimated from time courses of independent components. The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics. The increased connectivity between the lateral DMN and right control network was significantly correlated with negative and anergia factor scores in the schizophrenic patients. The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics. The altered DMN connectivity may underlie the hallucinations, delusions, thought disturbances, and negative symptoms involved in schizophrenia. Furthermore, DMN connectivity patterns could be used to differentiate patients from controls with 76.9% accuracy. These findings may shed new light on the distinct role of DMN subsystems in schizophrenia, thereby furthering our understanding of the pathophysiology of schizophrenia. Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

No MeSH data available.


Related in: MedlinePlus

Comparison of intra-default functional connectivity between schizophrenic patients and healthy controls (two-sample t-test, P < 0.05, uncorrected).The upper left panel presents the default mode network (DMN) template based on prior parcellation of the cerebrum22. The spatial expression and corresponding time courses of the DMN subnetworks for the two groups are also presented (one-sample t-test, P < 0.05, FWE corrected). The anterior DMN mainly consists of the medial prefrontal cortex and portions of the posterior cingulate cortex and bilateral parietal cortex. The posterior DMN consists predominantly of the bilateral precuneus and posterior cingulate cortex, as well as part of the bilateral parietal cortex. The lateral DMN primarily consists of the bilateral parietal cortex, bilateral temporal cortex, and part of the lateral prefrontal cortex. It was observed that positive functional connectivity between the lateral and anterior DMNs was increased in schizophrenic patients relative to healthy controls (P < 0.05, uncorrected), and in non-medicated patients (n = 34) relative to healthy controls (P < 0.05, uncorrected). The red lines represent positive functional connectivity. The solid and dashed lines represent an increase and decrease in schizophrenic patients relative to healthy controls, respectively. CARET software (CARET; http://brainvis.wustl.edu) was used for surface rendering.
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f1: Comparison of intra-default functional connectivity between schizophrenic patients and healthy controls (two-sample t-test, P < 0.05, uncorrected).The upper left panel presents the default mode network (DMN) template based on prior parcellation of the cerebrum22. The spatial expression and corresponding time courses of the DMN subnetworks for the two groups are also presented (one-sample t-test, P < 0.05, FWE corrected). The anterior DMN mainly consists of the medial prefrontal cortex and portions of the posterior cingulate cortex and bilateral parietal cortex. The posterior DMN consists predominantly of the bilateral precuneus and posterior cingulate cortex, as well as part of the bilateral parietal cortex. The lateral DMN primarily consists of the bilateral parietal cortex, bilateral temporal cortex, and part of the lateral prefrontal cortex. It was observed that positive functional connectivity between the lateral and anterior DMNs was increased in schizophrenic patients relative to healthy controls (P < 0.05, uncorrected), and in non-medicated patients (n = 34) relative to healthy controls (P < 0.05, uncorrected). The red lines represent positive functional connectivity. The solid and dashed lines represent an increase and decrease in schizophrenic patients relative to healthy controls, respectively. CARET software (CARET; http://brainvis.wustl.edu) was used for surface rendering.

Mentions: Fourteen functionally relevant ICNs were identified by group ICA analysis according to the previous studies2324, as shown in Supplementary Fig. 1 (one-sample t-test, P < 0.05, FWE corrected). Three components, or subnetworks, of the DMN were identified: an anterior subnetwork with a correlation (over voxels) of 0.36 (P < 0.001) with the DMN template; a posterior subnetwork with a correlation of 0.19 (P < 0.001); and a lateral subnetwork with a correlation of 0.38 (P < 0.001) (Supplementary Fig. 1). The corresponding time courses of the three subnetworks are shown in Fig. 1. The anterior DMN had the highest amplitude in the medial prefrontal cortex, the posterior DMN had the highest amplitude in the posterior cingulate cortex/precuneus, and the lateral DMN had the highest amplitude in the bilateral temporal cortex. The three networks are spatially independent and their time courses are asynchronous.


Evidence of a dissociation pattern in default mode subnetwork functional connectivity in schizophrenia.

Wang H, Zeng LL, Chen Y, Yin H, Tan Q, Hu D - Sci Rep (2015)

Comparison of intra-default functional connectivity between schizophrenic patients and healthy controls (two-sample t-test, P < 0.05, uncorrected).The upper left panel presents the default mode network (DMN) template based on prior parcellation of the cerebrum22. The spatial expression and corresponding time courses of the DMN subnetworks for the two groups are also presented (one-sample t-test, P < 0.05, FWE corrected). The anterior DMN mainly consists of the medial prefrontal cortex and portions of the posterior cingulate cortex and bilateral parietal cortex. The posterior DMN consists predominantly of the bilateral precuneus and posterior cingulate cortex, as well as part of the bilateral parietal cortex. The lateral DMN primarily consists of the bilateral parietal cortex, bilateral temporal cortex, and part of the lateral prefrontal cortex. It was observed that positive functional connectivity between the lateral and anterior DMNs was increased in schizophrenic patients relative to healthy controls (P < 0.05, uncorrected), and in non-medicated patients (n = 34) relative to healthy controls (P < 0.05, uncorrected). The red lines represent positive functional connectivity. The solid and dashed lines represent an increase and decrease in schizophrenic patients relative to healthy controls, respectively. CARET software (CARET; http://brainvis.wustl.edu) was used for surface rendering.
© Copyright Policy - open-access
Related In: Results  -  Collection

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f1: Comparison of intra-default functional connectivity between schizophrenic patients and healthy controls (two-sample t-test, P < 0.05, uncorrected).The upper left panel presents the default mode network (DMN) template based on prior parcellation of the cerebrum22. The spatial expression and corresponding time courses of the DMN subnetworks for the two groups are also presented (one-sample t-test, P < 0.05, FWE corrected). The anterior DMN mainly consists of the medial prefrontal cortex and portions of the posterior cingulate cortex and bilateral parietal cortex. The posterior DMN consists predominantly of the bilateral precuneus and posterior cingulate cortex, as well as part of the bilateral parietal cortex. The lateral DMN primarily consists of the bilateral parietal cortex, bilateral temporal cortex, and part of the lateral prefrontal cortex. It was observed that positive functional connectivity between the lateral and anterior DMNs was increased in schizophrenic patients relative to healthy controls (P < 0.05, uncorrected), and in non-medicated patients (n = 34) relative to healthy controls (P < 0.05, uncorrected). The red lines represent positive functional connectivity. The solid and dashed lines represent an increase and decrease in schizophrenic patients relative to healthy controls, respectively. CARET software (CARET; http://brainvis.wustl.edu) was used for surface rendering.
Mentions: Fourteen functionally relevant ICNs were identified by group ICA analysis according to the previous studies2324, as shown in Supplementary Fig. 1 (one-sample t-test, P < 0.05, FWE corrected). Three components, or subnetworks, of the DMN were identified: an anterior subnetwork with a correlation (over voxels) of 0.36 (P < 0.001) with the DMN template; a posterior subnetwork with a correlation of 0.19 (P < 0.001); and a lateral subnetwork with a correlation of 0.38 (P < 0.001) (Supplementary Fig. 1). The corresponding time courses of the three subnetworks are shown in Fig. 1. The anterior DMN had the highest amplitude in the medial prefrontal cortex, the posterior DMN had the highest amplitude in the posterior cingulate cortex/precuneus, and the lateral DMN had the highest amplitude in the bilateral temporal cortex. The three networks are spatially independent and their time courses are asynchronous.

Bottom Line: The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics.The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics.Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Xijing Hospital of the Fourth Military Medical University, Xi'an Shaanxi 710032, People's Republic of China.

ABSTRACT
The default mode network (DMN) is suggested to play a pivotal role in schizophrenia; however, the dissociation pattern of functional connectivity of DMN subsystems remains uncharacterized in this disease. In this study, resting-state fMRI data were acquired from 55 schizophrenic patients and 53 matched healthy controls. DMN connectivity was estimated from time courses of independent components. The lateral DMN exhibited decreased connectivity with the unimodal sensorimotor cortex but increased connectivity with the heteromodal association areas in schizophrenics. The increased connectivity between the lateral DMN and right control network was significantly correlated with negative and anergia factor scores in the schizophrenic patients. The anterior and posterior DMNs exhibited increased and decreased connectivity with the right control and lateral visual networks, respectively, in schizophrenics. The altered DMN connectivity may underlie the hallucinations, delusions, thought disturbances, and negative symptoms involved in schizophrenia. Furthermore, DMN connectivity patterns could be used to differentiate patients from controls with 76.9% accuracy. These findings may shed new light on the distinct role of DMN subsystems in schizophrenia, thereby furthering our understanding of the pathophysiology of schizophrenia. Elucidating key disease-related DMN subsystems is critical for identifying treatment targets and aiding in the clinical diagnosis and development of treatment strategies.

No MeSH data available.


Related in: MedlinePlus