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Treatment of sunitinib-induced hypertension in solid tumor by nitric oxide donors.

León-Mateos L, Mosquera J, Antón Aparicio L - Redox Biol (2015)

Bottom Line: So inhibition of signaling through the VEGF pathway would lead to a decrease in NO production, resulting in an increase in vascular resistance and blood pressure.Secondly a decrease in the number of microvascular endothelial cells and subsequent depletion of normal microvessel density (rarefaction) occurs upon VEGF signaling inhibition.NO donors could be successfully used not only for the treatment of developed angiogenesis-inhibitor-induced hypertension but also for preventive effects.

View Article: PubMed Central - PubMed

Affiliation: Servicio Galego de Saúde, Edificio Administrativo San Lázaro s/n, 15781 Santiago de Compostela, Spain. Electronic address: luis.leon.mateos@sergas.es.

No MeSH data available.


Related in: MedlinePlus

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Treatment of sunitinib-induced hypertension in solid tumor by nitric oxide donors.

León-Mateos L, Mosquera J, Antón Aparicio L - Redox Biol (2015)

© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588456&req=5

Bottom Line: So inhibition of signaling through the VEGF pathway would lead to a decrease in NO production, resulting in an increase in vascular resistance and blood pressure.Secondly a decrease in the number of microvascular endothelial cells and subsequent depletion of normal microvessel density (rarefaction) occurs upon VEGF signaling inhibition.NO donors could be successfully used not only for the treatment of developed angiogenesis-inhibitor-induced hypertension but also for preventive effects.

View Article: PubMed Central - PubMed

Affiliation: Servicio Galego de Saúde, Edificio Administrativo San Lázaro s/n, 15781 Santiago de Compostela, Spain. Electronic address: luis.leon.mateos@sergas.es.

No MeSH data available.


Related in: MedlinePlus