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Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.

Montojo CA, Congdon E, Hwang L, Jalbrzikowski M, Kushan L, Vesagas TK, Jonas RK, Ventura J, Bilder RM, Bearden CE - Neuroimage Clin (2015)

Bottom Line: •22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs.ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

View Article: PubMed Central - PubMed

Affiliation: University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

ABSTRACT
•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

No MeSH data available.


Related in: MedlinePlus

Neural activity differences for successful stopping: 22q11DS versus ADHD. Turquoise maps represent activity from the contrast of Stop Successful–Go, ADHD > 22q11DS, to investigate differences in activity related to response inhibition. Brain orientations are labeled such that S = superior, I = inferior, P = posterior, and A = anterior; R = right and L = left.
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f0015: Neural activity differences for successful stopping: 22q11DS versus ADHD. Turquoise maps represent activity from the contrast of Stop Successful–Go, ADHD > 22q11DS, to investigate differences in activity related to response inhibition. Brain orientations are labeled such that S = superior, I = inferior, P = posterior, and A = anterior; R = right and L = left.

Mentions: As shown in Fig. 3 and Table 3, a direct comparison between ADHD and 22q11DS patients revealed significantly increased activation that was specific to the bilateral middle frontal gyrus for patients with ADHD relative to those with 22q11DS. There were no regions showing greater activation for 22q11DS patients as compared with ADHD patients. Since we observed a significant difference in performance for Go trials, which may affect the neural activity findings for the Stop Successful–Go contrast, we conducted a follow-up analysis on the Stop Successful–Null contrast and found similar results to those observed for the Stop Successful–Go contrast (see the Supplementary material for details).


Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.

Montojo CA, Congdon E, Hwang L, Jalbrzikowski M, Kushan L, Vesagas TK, Jonas RK, Ventura J, Bilder RM, Bearden CE - Neuroimage Clin (2015)

Neural activity differences for successful stopping: 22q11DS versus ADHD. Turquoise maps represent activity from the contrast of Stop Successful–Go, ADHD > 22q11DS, to investigate differences in activity related to response inhibition. Brain orientations are labeled such that S = superior, I = inferior, P = posterior, and A = anterior; R = right and L = left.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588418&req=5

f0015: Neural activity differences for successful stopping: 22q11DS versus ADHD. Turquoise maps represent activity from the contrast of Stop Successful–Go, ADHD > 22q11DS, to investigate differences in activity related to response inhibition. Brain orientations are labeled such that S = superior, I = inferior, P = posterior, and A = anterior; R = right and L = left.
Mentions: As shown in Fig. 3 and Table 3, a direct comparison between ADHD and 22q11DS patients revealed significantly increased activation that was specific to the bilateral middle frontal gyrus for patients with ADHD relative to those with 22q11DS. There were no regions showing greater activation for 22q11DS patients as compared with ADHD patients. Since we observed a significant difference in performance for Go trials, which may affect the neural activity findings for the Stop Successful–Go contrast, we conducted a follow-up analysis on the Stop Successful–Null contrast and found similar results to those observed for the Stop Successful–Go contrast (see the Supplementary material for details).

Bottom Line: •22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs.ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

View Article: PubMed Central - PubMed

Affiliation: University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

ABSTRACT
•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

No MeSH data available.


Related in: MedlinePlus