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Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.

Montojo CA, Congdon E, Hwang L, Jalbrzikowski M, Kushan L, Vesagas TK, Jonas RK, Ventura J, Bilder RM, Bearden CE - Neuroimage Clin (2015)

Bottom Line: •22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs.ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

View Article: PubMed Central - PubMed

Affiliation: University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

ABSTRACT
•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

No MeSH data available.


Related in: MedlinePlus

Conjunction analysis showing significant differences in RI-related neural activity common to 22q11DS and ADHD patients compared to controls. Nine anatomically-defined ROIs were intersected with the conjunction group map to extract percent signal change. The X-axis represents the group (controls = gray, ADHD patients = dotted, 22q11DS = black) and the Y-axis represents percent signal change.
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f0010: Conjunction analysis showing significant differences in RI-related neural activity common to 22q11DS and ADHD patients compared to controls. Nine anatomically-defined ROIs were intersected with the conjunction group map to extract percent signal change. The X-axis represents the group (controls = gray, ADHD patients = dotted, 22q11DS = black) and the Y-axis represents percent signal change.

Mentions: As controls showed greater RI-related activation than both 22q11DS and ADHD patients across multiple brain regions, we conducted a conjunction analysis in order to determine the regions common to both clinical groups (Price and Friston, 1997). As illustrated in Fig. 1, conjunction regions that showed overlap for 22q11DS patients and ADHD patients compared to controls included the medial frontal cortex/anterior cingulate/paracingulate gyrus, right middle frontal gyrus, left inferior parietal cortex, cerebellum (bilaterally), thalamus (bilaterally), and right middle temporal gyrus. Corresponding percent signal change plots are illustrated in Fig. 2, showing that controls show greater activity than both ADHD and 22q11DS patients within RI-related regions, including the ACC, bilateral cerebellum, left inferior parietal cortex, right middle frontal gyrus, right middle temporal gyrus, paracingulate gyrus, superior frontal gyrus, and bilateral thalamus.


Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.

Montojo CA, Congdon E, Hwang L, Jalbrzikowski M, Kushan L, Vesagas TK, Jonas RK, Ventura J, Bilder RM, Bearden CE - Neuroimage Clin (2015)

Conjunction analysis showing significant differences in RI-related neural activity common to 22q11DS and ADHD patients compared to controls. Nine anatomically-defined ROIs were intersected with the conjunction group map to extract percent signal change. The X-axis represents the group (controls = gray, ADHD patients = dotted, 22q11DS = black) and the Y-axis represents percent signal change.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588418&req=5

f0010: Conjunction analysis showing significant differences in RI-related neural activity common to 22q11DS and ADHD patients compared to controls. Nine anatomically-defined ROIs were intersected with the conjunction group map to extract percent signal change. The X-axis represents the group (controls = gray, ADHD patients = dotted, 22q11DS = black) and the Y-axis represents percent signal change.
Mentions: As controls showed greater RI-related activation than both 22q11DS and ADHD patients across multiple brain regions, we conducted a conjunction analysis in order to determine the regions common to both clinical groups (Price and Friston, 1997). As illustrated in Fig. 1, conjunction regions that showed overlap for 22q11DS patients and ADHD patients compared to controls included the medial frontal cortex/anterior cingulate/paracingulate gyrus, right middle frontal gyrus, left inferior parietal cortex, cerebellum (bilaterally), thalamus (bilaterally), and right middle temporal gyrus. Corresponding percent signal change plots are illustrated in Fig. 2, showing that controls show greater activity than both ADHD and 22q11DS patients within RI-related regions, including the ACC, bilateral cerebellum, left inferior parietal cortex, right middle frontal gyrus, right middle temporal gyrus, paracingulate gyrus, superior frontal gyrus, and bilateral thalamus.

Bottom Line: •22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs.ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

View Article: PubMed Central - PubMed

Affiliation: University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

ABSTRACT
•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

No MeSH data available.


Related in: MedlinePlus