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Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.

Montojo CA, Congdon E, Hwang L, Jalbrzikowski M, Kushan L, Vesagas TK, Jonas RK, Ventura J, Bilder RM, Bearden CE - Neuroimage Clin (2015)

Bottom Line: •22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs.ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

View Article: PubMed Central - PubMed

Affiliation: University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

ABSTRACT
•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

No MeSH data available.


Related in: MedlinePlus

Neural activity during successful RI (Stop-Successful vs. Go contrast): 22q11DS and ADHD participants versus controls. (a) Green clusters represent activity from the contrast of controls > 22q11DS, and dark blue clusters represent activity from the contrast of controls > ADHD. (b) Red colors represent regions showing a conjunction of neural activity from the contrasts of controls > 22q11DS and controls > ADHD.
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f0005: Neural activity during successful RI (Stop-Successful vs. Go contrast): 22q11DS and ADHD participants versus controls. (a) Green clusters represent activity from the contrast of controls > 22q11DS, and dark blue clusters represent activity from the contrast of controls > ADHD. (b) Red colors represent regions showing a conjunction of neural activity from the contrasts of controls > 22q11DS and controls > ADHD.

Mentions: As shown in Fig. 1 and Table 3, a direct comparison between controls and 22q11DS patients during successful RI (Stop Successful–Go contrast) revealed significantly increased activation in controls relative to 22q11DS patients in the bilateral medial frontal cortex/ACC/paracingulate gyrus, bilateral middle/inferior/superior frontal gyrus, bilateral occipital and parietal regions, right middle temporal gyrus, posterior cingulate cortex (PCC), bilateral basal ganglia (thalamus) and cerebellum. There were no regions showing greater activation for 22q11DS patients as compared to controls. A direct comparison between controls and ADHD patients revealed a similar pattern of increased activation for controls relative to ADHD patients in the medial frontal cortex/ACC paracingulate, right middle frontal gyrus, bilateral inferior parietal cortex, bilateral middle temporal gyrus, bilateral occipital cortex, bilateral basal ganglia (thalamus), and cerebellum, while there were no regions showing greater activation for ADHD patients as compared to controls.


Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.

Montojo CA, Congdon E, Hwang L, Jalbrzikowski M, Kushan L, Vesagas TK, Jonas RK, Ventura J, Bilder RM, Bearden CE - Neuroimage Clin (2015)

Neural activity during successful RI (Stop-Successful vs. Go contrast): 22q11DS and ADHD participants versus controls. (a) Green clusters represent activity from the contrast of controls > 22q11DS, and dark blue clusters represent activity from the contrast of controls > ADHD. (b) Red colors represent regions showing a conjunction of neural activity from the contrasts of controls > 22q11DS and controls > ADHD.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588418&req=5

f0005: Neural activity during successful RI (Stop-Successful vs. Go contrast): 22q11DS and ADHD participants versus controls. (a) Green clusters represent activity from the contrast of controls > 22q11DS, and dark blue clusters represent activity from the contrast of controls > ADHD. (b) Red colors represent regions showing a conjunction of neural activity from the contrasts of controls > 22q11DS and controls > ADHD.
Mentions: As shown in Fig. 1 and Table 3, a direct comparison between controls and 22q11DS patients during successful RI (Stop Successful–Go contrast) revealed significantly increased activation in controls relative to 22q11DS patients in the bilateral medial frontal cortex/ACC/paracingulate gyrus, bilateral middle/inferior/superior frontal gyrus, bilateral occipital and parietal regions, right middle temporal gyrus, posterior cingulate cortex (PCC), bilateral basal ganglia (thalamus) and cerebellum. There were no regions showing greater activation for 22q11DS patients as compared to controls. A direct comparison between controls and ADHD patients revealed a similar pattern of increased activation for controls relative to ADHD patients in the medial frontal cortex/ACC paracingulate, right middle frontal gyrus, bilateral inferior parietal cortex, bilateral middle temporal gyrus, bilateral occipital cortex, bilateral basal ganglia (thalamus), and cerebellum, while there were no regions showing greater activation for ADHD patients as compared to controls.

Bottom Line: •22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs.ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

View Article: PubMed Central - PubMed

Affiliation: University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

ABSTRACT
•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

No MeSH data available.


Related in: MedlinePlus