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Sodium selenite supplementation does not fully restore oxidative stress-induced deiodinase dysfunction: Implications for the nonthyroidal illness syndrome.

Wajner SM, Rohenkohl HC, Serrano T, Maia AL - Redox Biol (2015)

Bottom Line: Increased ROS was paralleled by D1 and D2-decreased T3-production (P<0.01) and increased D3-catalyzed T3-inactivation (P<0.001).Selenite decreases the IL6-induced ROS and carbonyl content, while enhances Gpx and Trx activities.In conclusion, although sodium selenite reduces IL6-induced redox imbalance it does not fully repair deiodinase function.

View Article: PubMed Central - PubMed

Affiliation: Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

No MeSH data available.


Related in: MedlinePlus

Effect of increasing levels of sodium selenite (0–300 nM) on glutathione peroxidase activity (A), thioredoxin reductase (TRx) activity (B) and GSH (C) levels in MSTO-211 (●), HepG2 (▲) or MCF-7 (■) cells. Data are mean±SD of at least three independent experiments.*P<0.01.
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f0030: Effect of increasing levels of sodium selenite (0–300 nM) on glutathione peroxidase activity (A), thioredoxin reductase (TRx) activity (B) and GSH (C) levels in MSTO-211 (●), HepG2 (▲) or MCF-7 (■) cells. Data are mean±SD of at least three independent experiments.*P<0.01.

Mentions: Sodium selenite supplementation increased GPx and TRx activities in a dose dependent fashion in all cell lines (P<0.01; Fig. 6A and B), but it did not alter the intracellular GSH levels (all P>0.05; Fig. 6C).


Sodium selenite supplementation does not fully restore oxidative stress-induced deiodinase dysfunction: Implications for the nonthyroidal illness syndrome.

Wajner SM, Rohenkohl HC, Serrano T, Maia AL - Redox Biol (2015)

Effect of increasing levels of sodium selenite (0–300 nM) on glutathione peroxidase activity (A), thioredoxin reductase (TRx) activity (B) and GSH (C) levels in MSTO-211 (●), HepG2 (▲) or MCF-7 (■) cells. Data are mean±SD of at least three independent experiments.*P<0.01.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588414&req=5

f0030: Effect of increasing levels of sodium selenite (0–300 nM) on glutathione peroxidase activity (A), thioredoxin reductase (TRx) activity (B) and GSH (C) levels in MSTO-211 (●), HepG2 (▲) or MCF-7 (■) cells. Data are mean±SD of at least three independent experiments.*P<0.01.
Mentions: Sodium selenite supplementation increased GPx and TRx activities in a dose dependent fashion in all cell lines (P<0.01; Fig. 6A and B), but it did not alter the intracellular GSH levels (all P>0.05; Fig. 6C).

Bottom Line: Increased ROS was paralleled by D1 and D2-decreased T3-production (P<0.01) and increased D3-catalyzed T3-inactivation (P<0.001).Selenite decreases the IL6-induced ROS and carbonyl content, while enhances Gpx and Trx activities.In conclusion, although sodium selenite reduces IL6-induced redox imbalance it does not fully repair deiodinase function.

View Article: PubMed Central - PubMed

Affiliation: Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

No MeSH data available.


Related in: MedlinePlus