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A case of autoimmune epilepsy associated with anti-leucine-rich glioma inactivated subunit 1 antibodies manifesting electrical shock-like sensations and transparent sadness.

Murata Y, Watanabe O, Taniguchi G, Sone D, Fujioka M, Okazaki M, Nakagawa E, Watanabe Y, Watanabe M - Epilepsy Behav Case Rep (2015)

Bottom Line: Autoimmune epilepsy is an isolated phenotype of autoimmune encephalitis, which may be suspected in patients with unexplained adult-onset seizure disorders or resistance to antiepileptic drugs (AEDs).Antibodies against leucine-rich glioma inactivated subunit 1 of the voltage-gated potassium channel (VGKC) complex, recently termed anti-LGI-1 antibodies, are one of the causes of autoimmune epilepsies.Bizarre symptoms with extremely short duration and high frequency are clues to the possible presence of autoimmune epilepsy with anti-LGI-1 antibodies.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan.

ABSTRACT
Autoimmune epilepsy is an isolated phenotype of autoimmune encephalitis, which may be suspected in patients with unexplained adult-onset seizure disorders or resistance to antiepileptic drugs (AEDs). Antibodies against leucine-rich glioma inactivated subunit 1 of the voltage-gated potassium channel (VGKC) complex, recently termed anti-LGI-1 antibodies, are one of the causes of autoimmune epilepsies. Bizarre symptoms with extremely short duration and high frequency are clues to the possible presence of autoimmune epilepsy with anti-LGI-1 antibodies. Precise diagnosis is important because autoimmune epilepsy is treatable and the prognosis can be predicted.

No MeSH data available.


Related in: MedlinePlus

Interictal EEG.The EEG shows epileptiform discharges or slow waves.
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f0005: Interictal EEG.The EEG shows epileptiform discharges or slow waves.

Mentions: Full blood workup included routine tests to assess electrolytes, liver and renal function, vitamins B1 and B12, and autoimmune-related antibodies. All the test results were within normal ranges. Cerebrospinal fluid (CSF) examination showed no abnormality. The EEG showed no epileptiform discharges or slow waves (Fig. 1). A magnetic resonance imaging (MRI) (3T) scan was normal. 2-Deoxy-2-[18F] fluoro-d-glucose (18F-FDG) positron emission tomography/computed tomography (FDG-PET/CT) of the brain and body showed no hyper- or hypometabolism (Fig. 2). Although there were no other features to support an autoimmune etiology, we examined autoantibodies including anti-VGKC complex antibodies and intracellular autoantibodies (anti-Hu, Yo, Ri, Ma2/Ta, and amphiphysin). Serum anti-VGKC complex antibodies were elevated to 2493 pM (normal: < 100 pM). The target antigen of VGKC complex antibodies was LGI-1.


A case of autoimmune epilepsy associated with anti-leucine-rich glioma inactivated subunit 1 antibodies manifesting electrical shock-like sensations and transparent sadness.

Murata Y, Watanabe O, Taniguchi G, Sone D, Fujioka M, Okazaki M, Nakagawa E, Watanabe Y, Watanabe M - Epilepsy Behav Case Rep (2015)

Interictal EEG.The EEG shows epileptiform discharges or slow waves.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588408&req=5

f0005: Interictal EEG.The EEG shows epileptiform discharges or slow waves.
Mentions: Full blood workup included routine tests to assess electrolytes, liver and renal function, vitamins B1 and B12, and autoimmune-related antibodies. All the test results were within normal ranges. Cerebrospinal fluid (CSF) examination showed no abnormality. The EEG showed no epileptiform discharges or slow waves (Fig. 1). A magnetic resonance imaging (MRI) (3T) scan was normal. 2-Deoxy-2-[18F] fluoro-d-glucose (18F-FDG) positron emission tomography/computed tomography (FDG-PET/CT) of the brain and body showed no hyper- or hypometabolism (Fig. 2). Although there were no other features to support an autoimmune etiology, we examined autoantibodies including anti-VGKC complex antibodies and intracellular autoantibodies (anti-Hu, Yo, Ri, Ma2/Ta, and amphiphysin). Serum anti-VGKC complex antibodies were elevated to 2493 pM (normal: < 100 pM). The target antigen of VGKC complex antibodies was LGI-1.

Bottom Line: Autoimmune epilepsy is an isolated phenotype of autoimmune encephalitis, which may be suspected in patients with unexplained adult-onset seizure disorders or resistance to antiepileptic drugs (AEDs).Antibodies against leucine-rich glioma inactivated subunit 1 of the voltage-gated potassium channel (VGKC) complex, recently termed anti-LGI-1 antibodies, are one of the causes of autoimmune epilepsies.Bizarre symptoms with extremely short duration and high frequency are clues to the possible presence of autoimmune epilepsy with anti-LGI-1 antibodies.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan.

ABSTRACT
Autoimmune epilepsy is an isolated phenotype of autoimmune encephalitis, which may be suspected in patients with unexplained adult-onset seizure disorders or resistance to antiepileptic drugs (AEDs). Antibodies against leucine-rich glioma inactivated subunit 1 of the voltage-gated potassium channel (VGKC) complex, recently termed anti-LGI-1 antibodies, are one of the causes of autoimmune epilepsies. Bizarre symptoms with extremely short duration and high frequency are clues to the possible presence of autoimmune epilepsy with anti-LGI-1 antibodies. Precise diagnosis is important because autoimmune epilepsy is treatable and the prognosis can be predicted.

No MeSH data available.


Related in: MedlinePlus