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Value of T1/T2-weighted magnetic resonance imaging registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization.

You JY, Lee HJ, Hwang SI, Bae YJ, Kim H, Hong H, Choe G - Prostate Int (2015)

Bottom Line: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members.There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1.There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea.

ABSTRACT

Background: The aim of this study was to evaluate the value of T1/T2-weighted imaging (T1/T2WI) registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization on prostate magnetic resonance imaging (MRI).

Methods: Twenty-one men with pathology-proven prostate cancer who underwent preoperative MRI in a single institution were selected. The zonal anatomy was divided into 16 sections. T2WI, T1/T2-weighted registered imaging (T1/T2RI), T2WI combined with diffusion-weighted imaging (T2WI + DWI), and T1/T2RI combined with DWI (T1/T2RI + DWI) were scored for the likelihood of cancer by two radiology faculty members and two trainees, and were compared with histology results. Areas under the receiver operating characteristics curve (AUCs) were used to assess diagnostic accuracy.

Results: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members. There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1. There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

Conclusions: T1/T2WI registration is a feasible technique. For less experienced readers, T1/T2RI is better than T2WI in localization of prostate cancer.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic curves for detection of prostate cancer on T2-weighted imaging (T2WI; dotted line) and T1/T2-weighted registered imaging (T1/T2RI, solid line). (A) For Reader 1, areas under the curve (AUCs) of both T2WI and T1/T2RI were 0.60 without statistical significance (P = 0.93). (B) For Reader 2, the AUCs of both T2WI and T1/T2RI were 0.62 without statistical significance (P = 0.97). (C) For Reader 3, the AUC was significantly higher (P = 0.03) for T1/T2RI (AUC = 0.60) than for T2WI (AUC = 0.54). (D) For Reader 4, the AUC was significantly higher (P = 0.04) for T1/T2RI (AUC = 0.62) than for T2WI (AUC = 0.56).
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fig3: Receiver operating characteristic curves for detection of prostate cancer on T2-weighted imaging (T2WI; dotted line) and T1/T2-weighted registered imaging (T1/T2RI, solid line). (A) For Reader 1, areas under the curve (AUCs) of both T2WI and T1/T2RI were 0.60 without statistical significance (P = 0.93). (B) For Reader 2, the AUCs of both T2WI and T1/T2RI were 0.62 without statistical significance (P = 0.97). (C) For Reader 3, the AUC was significantly higher (P = 0.03) for T1/T2RI (AUC = 0.60) than for T2WI (AUC = 0.54). (D) For Reader 4, the AUC was significantly higher (P = 0.04) for T1/T2RI (AUC = 0.62) than for T2WI (AUC = 0.56).

Mentions: For faculty members, Reader 1 and Reader 2, no significant improvement of T1/T2RI (AUC values of 0.60 and 0.62, respectively) was observed in tumor detection compared with T2WI (AUC values of 0.60 and 0.62, respectively). However, the AUC values of T1/T2RI were significantly higher than those of T2WI for the trainees, Reader 3 (0.60 and 0.54, respectively, P = 0.03) and Reader 4 (0.62 and 0.56, respectively, P = 0.04; Fig. 3). As a result of adding DWI on T2WI, the AUC value of T2WI + DWI was significantly higher than that of T2WI for three of four readers. However, there was no additional benefit for adding DWI on T1/T2RI in tumor detection for all readers. When comparing AUC values between T2WI + DWI and T1/T2RI, Reader 1 achieved a significant higher AUC value for T2WI + DWI than for T1/T2RI (0.68 and 0.60, respectively, P = 0.02), whereas others showed no significant difference between T2WI + DWI and T1/T2RI.


Value of T1/T2-weighted magnetic resonance imaging registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization.

You JY, Lee HJ, Hwang SI, Bae YJ, Kim H, Hong H, Choe G - Prostate Int (2015)

Receiver operating characteristic curves for detection of prostate cancer on T2-weighted imaging (T2WI; dotted line) and T1/T2-weighted registered imaging (T1/T2RI, solid line). (A) For Reader 1, areas under the curve (AUCs) of both T2WI and T1/T2RI were 0.60 without statistical significance (P = 0.93). (B) For Reader 2, the AUCs of both T2WI and T1/T2RI were 0.62 without statistical significance (P = 0.97). (C) For Reader 3, the AUC was significantly higher (P = 0.03) for T1/T2RI (AUC = 0.60) than for T2WI (AUC = 0.54). (D) For Reader 4, the AUC was significantly higher (P = 0.04) for T1/T2RI (AUC = 0.62) than for T2WI (AUC = 0.56).
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fig3: Receiver operating characteristic curves for detection of prostate cancer on T2-weighted imaging (T2WI; dotted line) and T1/T2-weighted registered imaging (T1/T2RI, solid line). (A) For Reader 1, areas under the curve (AUCs) of both T2WI and T1/T2RI were 0.60 without statistical significance (P = 0.93). (B) For Reader 2, the AUCs of both T2WI and T1/T2RI were 0.62 without statistical significance (P = 0.97). (C) For Reader 3, the AUC was significantly higher (P = 0.03) for T1/T2RI (AUC = 0.60) than for T2WI (AUC = 0.54). (D) For Reader 4, the AUC was significantly higher (P = 0.04) for T1/T2RI (AUC = 0.62) than for T2WI (AUC = 0.56).
Mentions: For faculty members, Reader 1 and Reader 2, no significant improvement of T1/T2RI (AUC values of 0.60 and 0.62, respectively) was observed in tumor detection compared with T2WI (AUC values of 0.60 and 0.62, respectively). However, the AUC values of T1/T2RI were significantly higher than those of T2WI for the trainees, Reader 3 (0.60 and 0.54, respectively, P = 0.03) and Reader 4 (0.62 and 0.56, respectively, P = 0.04; Fig. 3). As a result of adding DWI on T2WI, the AUC value of T2WI + DWI was significantly higher than that of T2WI for three of four readers. However, there was no additional benefit for adding DWI on T1/T2RI in tumor detection for all readers. When comparing AUC values between T2WI + DWI and T1/T2RI, Reader 1 achieved a significant higher AUC value for T2WI + DWI than for T1/T2RI (0.68 and 0.60, respectively, P = 0.02), whereas others showed no significant difference between T2WI + DWI and T1/T2RI.

Bottom Line: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members.There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1.There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea.

ABSTRACT

Background: The aim of this study was to evaluate the value of T1/T2-weighted imaging (T1/T2WI) registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization on prostate magnetic resonance imaging (MRI).

Methods: Twenty-one men with pathology-proven prostate cancer who underwent preoperative MRI in a single institution were selected. The zonal anatomy was divided into 16 sections. T2WI, T1/T2-weighted registered imaging (T1/T2RI), T2WI combined with diffusion-weighted imaging (T2WI + DWI), and T1/T2RI combined with DWI (T1/T2RI + DWI) were scored for the likelihood of cancer by two radiology faculty members and two trainees, and were compared with histology results. Areas under the receiver operating characteristics curve (AUCs) were used to assess diagnostic accuracy.

Results: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members. There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1. There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

Conclusions: T1/T2WI registration is a feasible technique. For less experienced readers, T1/T2RI is better than T2WI in localization of prostate cancer.

No MeSH data available.


Related in: MedlinePlus