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Value of T1/T2-weighted magnetic resonance imaging registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization.

You JY, Lee HJ, Hwang SI, Bae YJ, Kim H, Hong H, Choe G - Prostate Int (2015)

Bottom Line: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members.There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1.There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea.

ABSTRACT

Background: The aim of this study was to evaluate the value of T1/T2-weighted imaging (T1/T2WI) registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization on prostate magnetic resonance imaging (MRI).

Methods: Twenty-one men with pathology-proven prostate cancer who underwent preoperative MRI in a single institution were selected. The zonal anatomy was divided into 16 sections. T2WI, T1/T2-weighted registered imaging (T1/T2RI), T2WI combined with diffusion-weighted imaging (T2WI + DWI), and T1/T2RI combined with DWI (T1/T2RI + DWI) were scored for the likelihood of cancer by two radiology faculty members and two trainees, and were compared with histology results. Areas under the receiver operating characteristics curve (AUCs) were used to assess diagnostic accuracy.

Results: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members. There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1. There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

Conclusions: T1/T2WI registration is a feasible technique. For less experienced readers, T1/T2RI is better than T2WI in localization of prostate cancer.

No MeSH data available.


Related in: MedlinePlus

Software program for T1/T2-weighted imaging (T1/T2WI) registration. Using the Prostate Fusion Tool software program, T1/T2-weighted registered imaging (A) is generated by designating a region of interest with four or more points on T2WI (B) and (C) T1WI. (D) Finally, T1/T2-weighted registered imaging can be compared with a photomicrograph of pathologic specimen.
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fig2: Software program for T1/T2-weighted imaging (T1/T2WI) registration. Using the Prostate Fusion Tool software program, T1/T2-weighted registered imaging (A) is generated by designating a region of interest with four or more points on T2WI (B) and (C) T1WI. (D) Finally, T1/T2-weighted registered imaging can be compared with a photomicrograph of pathologic specimen.

Mentions: T1/T2RI was generated based on routine spin-echo sequences of T1WI and T2WI using the Prostate Fusion Tool software program, which was developed in the Visual Computing and Medical Imaging Laboratory (VCMI Lab) at the College of Information and Media, Seoul Women’s University, Korea (Fig. 2). Using this program, any signal intensity over a selected threshold value on T1WI was superimposed on T2WI within the specified boundary. In our study, we use the fixed threshold value of T1 signal intensity. The fixed optimal threshold value of T1 signal intensity was selected by a preliminary test using sample data, which was not included in our study.


Value of T1/T2-weighted magnetic resonance imaging registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization.

You JY, Lee HJ, Hwang SI, Bae YJ, Kim H, Hong H, Choe G - Prostate Int (2015)

Software program for T1/T2-weighted imaging (T1/T2WI) registration. Using the Prostate Fusion Tool software program, T1/T2-weighted registered imaging (A) is generated by designating a region of interest with four or more points on T2WI (B) and (C) T1WI. (D) Finally, T1/T2-weighted registered imaging can be compared with a photomicrograph of pathologic specimen.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588389&req=5

fig2: Software program for T1/T2-weighted imaging (T1/T2WI) registration. Using the Prostate Fusion Tool software program, T1/T2-weighted registered imaging (A) is generated by designating a region of interest with four or more points on T2WI (B) and (C) T1WI. (D) Finally, T1/T2-weighted registered imaging can be compared with a photomicrograph of pathologic specimen.
Mentions: T1/T2RI was generated based on routine spin-echo sequences of T1WI and T2WI using the Prostate Fusion Tool software program, which was developed in the Visual Computing and Medical Imaging Laboratory (VCMI Lab) at the College of Information and Media, Seoul Women’s University, Korea (Fig. 2). Using this program, any signal intensity over a selected threshold value on T1WI was superimposed on T2WI within the specified boundary. In our study, we use the fixed threshold value of T1 signal intensity. The fixed optimal threshold value of T1 signal intensity was selected by a preliminary test using sample data, which was not included in our study.

Bottom Line: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members.There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1.There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea.

ABSTRACT

Background: The aim of this study was to evaluate the value of T1/T2-weighted imaging (T1/T2WI) registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization on prostate magnetic resonance imaging (MRI).

Methods: Twenty-one men with pathology-proven prostate cancer who underwent preoperative MRI in a single institution were selected. The zonal anatomy was divided into 16 sections. T2WI, T1/T2-weighted registered imaging (T1/T2RI), T2WI combined with diffusion-weighted imaging (T2WI + DWI), and T1/T2RI combined with DWI (T1/T2RI + DWI) were scored for the likelihood of cancer by two radiology faculty members and two trainees, and were compared with histology results. Areas under the receiver operating characteristics curve (AUCs) were used to assess diagnostic accuracy.

Results: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members. There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1. There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

Conclusions: T1/T2WI registration is a feasible technique. For less experienced readers, T1/T2RI is better than T2WI in localization of prostate cancer.

No MeSH data available.


Related in: MedlinePlus