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Value of T1/T2-weighted magnetic resonance imaging registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization.

You JY, Lee HJ, Hwang SI, Bae YJ, Kim H, Hong H, Choe G - Prostate Int (2015)

Bottom Line: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members.There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1.There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea.

ABSTRACT

Background: The aim of this study was to evaluate the value of T1/T2-weighted imaging (T1/T2WI) registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization on prostate magnetic resonance imaging (MRI).

Methods: Twenty-one men with pathology-proven prostate cancer who underwent preoperative MRI in a single institution were selected. The zonal anatomy was divided into 16 sections. T2WI, T1/T2-weighted registered imaging (T1/T2RI), T2WI combined with diffusion-weighted imaging (T2WI + DWI), and T1/T2RI combined with DWI (T1/T2RI + DWI) were scored for the likelihood of cancer by two radiology faculty members and two trainees, and were compared with histology results. Areas under the receiver operating characteristics curve (AUCs) were used to assess diagnostic accuracy.

Results: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members. There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1. There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

Conclusions: T1/T2WI registration is a feasible technique. For less experienced readers, T1/T2RI is better than T2WI in localization of prostate cancer.

No MeSH data available.


Related in: MedlinePlus

The basic concept of T1/T2-weighted imaging (T1/T2WI) registration. The signal intensity of hemorrhage (H) is same as that of prostate cancer (C) on T2WI; however, it is different on T1WI. To reduce the hemorrhage effect on T2WI, any T1 signal intensity above a selected threshold value is superimposed on T2WI using the imaging registration technique. After undergoing this process, T2 signal intensity of the prostate cancer would be more conspicuous, whereas that of the hemorrhage would be suppressed.
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fig1: The basic concept of T1/T2-weighted imaging (T1/T2WI) registration. The signal intensity of hemorrhage (H) is same as that of prostate cancer (C) on T2WI; however, it is different on T1WI. To reduce the hemorrhage effect on T2WI, any T1 signal intensity above a selected threshold value is superimposed on T2WI using the imaging registration technique. After undergoing this process, T2 signal intensity of the prostate cancer would be more conspicuous, whereas that of the hemorrhage would be suppressed.

Mentions: T1-weighted imaging (T1WI) is often helpful for distinguishing hemorrhage from background tissue, although abnormal lesion such as prostate cancer is indistinguishable due to its poor tissue contrast. Thus, we hypothesized that if we could automatically suppress the signal intensity of hemorrhage on T2WI using its T1 signal intensity, T2 signal intensity of the prostate cancer would be more conspicuous and the diagnostic performance of prostate MRI would be improved. This hypothesis has motivated investigation of the potential usefulness of imaging registration technique by summation of the different signal intensities of hemorrhage from T1WI and T2WI (Fig. 1).


Value of T1/T2-weighted magnetic resonance imaging registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization.

You JY, Lee HJ, Hwang SI, Bae YJ, Kim H, Hong H, Choe G - Prostate Int (2015)

The basic concept of T1/T2-weighted imaging (T1/T2WI) registration. The signal intensity of hemorrhage (H) is same as that of prostate cancer (C) on T2WI; however, it is different on T1WI. To reduce the hemorrhage effect on T2WI, any T1 signal intensity above a selected threshold value is superimposed on T2WI using the imaging registration technique. After undergoing this process, T2 signal intensity of the prostate cancer would be more conspicuous, whereas that of the hemorrhage would be suppressed.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588389&req=5

fig1: The basic concept of T1/T2-weighted imaging (T1/T2WI) registration. The signal intensity of hemorrhage (H) is same as that of prostate cancer (C) on T2WI; however, it is different on T1WI. To reduce the hemorrhage effect on T2WI, any T1 signal intensity above a selected threshold value is superimposed on T2WI using the imaging registration technique. After undergoing this process, T2 signal intensity of the prostate cancer would be more conspicuous, whereas that of the hemorrhage would be suppressed.
Mentions: T1-weighted imaging (T1WI) is often helpful for distinguishing hemorrhage from background tissue, although abnormal lesion such as prostate cancer is indistinguishable due to its poor tissue contrast. Thus, we hypothesized that if we could automatically suppress the signal intensity of hemorrhage on T2WI using its T1 signal intensity, T2 signal intensity of the prostate cancer would be more conspicuous and the diagnostic performance of prostate MRI would be improved. This hypothesis has motivated investigation of the potential usefulness of imaging registration technique by summation of the different signal intensities of hemorrhage from T1WI and T2WI (Fig. 1).

Bottom Line: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members.There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1.There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea.

ABSTRACT

Background: The aim of this study was to evaluate the value of T1/T2-weighted imaging (T1/T2WI) registration to reduce the postbiopsy hemorrhage effect for prostate cancer localization on prostate magnetic resonance imaging (MRI).

Methods: Twenty-one men with pathology-proven prostate cancer who underwent preoperative MRI in a single institution were selected. The zonal anatomy was divided into 16 sections. T2WI, T1/T2-weighted registered imaging (T1/T2RI), T2WI combined with diffusion-weighted imaging (T2WI + DWI), and T1/T2RI combined with DWI (T1/T2RI + DWI) were scored for the likelihood of cancer by two radiology faculty members and two trainees, and were compared with histology results. Areas under the receiver operating characteristics curve (AUCs) were used to assess diagnostic accuracy.

Results: For the trainees (Reader 3 and Reader 4), the AUC values were significantly higher (P < 0.05) for T1/T2RI (0.60 and 0.62, respectively) than for T2WI (0.54 and 0.56, respectively) in tumor detection, whereas no significant difference was observed for faculty members. There was no significant difference in AUC values between T1/T2RI and T2WI + DWI for all readers except for Reader 1. There was no additional diagnostic benefit for adding DWI with T1/T2RI for all readers.

Conclusions: T1/T2WI registration is a feasible technique. For less experienced readers, T1/T2RI is better than T2WI in localization of prostate cancer.

No MeSH data available.


Related in: MedlinePlus