Limits...
Prognostic role of microRNA-145 in prostate cancer: A systems review and meta-analysis.

Zhang X, Wu J - Prostate Int (2015)

Bottom Line: Pooled hazard ratios of miR-145 and 95% confidence intervals were calculated.Four studies with a total of 211 patients were included in this meta-analysis.Thus, lower miR-145 expression was found to significantly predict poorer outcomes.

View Article: PubMed Central - PubMed

Affiliation: Shanxi Medical University, Taiyuan, China.

ABSTRACT

Background: Many studies have shown that microRNAs (miRNAs) exhibit altered expression in various cancers and may play an important role as prognostic biomarkers. The present meta-analysis was undertaken to summarize recent studies of the use of microRNA-145 (miR-145) in the assessment of prostate cancer and to analyze the prognostic role of miR-145 for disease-free survival (DFS) outcome.

Methods: The present meta-analysis was performed by searching PubMed with the use of multiple search strategies. Data were extracted from studies examining DFS in patients with prostate cancer who showed lower expression of miR-145. Pooled hazard ratios of miR-145 and 95% confidence intervals were calculated. Four studies with a total of 211 patients were included in this meta-analysis.

Results: For overall DFS, the pooled hazard ratio of lower miR-145 expression in prostate cancer was 0.74 (95% confidence interval: 0.23-2.34, P = 0.001). Thus, lower miR-145 expression was found to significantly predict poorer outcomes.

Conclusions: The present findings suggest that downregulation of the expression of miR-145 might predict poor prognosis in patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the relationship between downregulation of miRNA-145 level and disease-free survival in patients with prostate cancer. CI, confidence interval; HR, hazard ratio; miRNA, microRNA.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4588372&req=5

fig2: Forest plot of the relationship between downregulation of miRNA-145 level and disease-free survival in patients with prostate cancer. CI, confidence interval; HR, hazard ratio; miRNA, microRNA.

Mentions: As shown in Table 1, all four studies reported the HR and 95% CI directly. No heterogeneity was detected between the studies, as indicated by evaluation of the relationship between the reduced miR-145 level and DFS (I2 = 0.0%, P = 0.721). Therefore, a pooled HR and its 95% CI were calculated by use of a fixed-effects model. Forest plots of the individual HR estimates and the results of the meta-analysis are presented in Fig. 2. According to these results, lower levels of miR-145 expression were significantly predictive of poor DFS. The pooled HR was 0.74 (95% CI: 0.23–2.34, P = 0.001). Publication bias was evaluated by using funnel plots and Begg's tests. No significant publication biases were observed in this meta-analysis (P = 0.089; Fig. 3).


Prognostic role of microRNA-145 in prostate cancer: A systems review and meta-analysis.

Zhang X, Wu J - Prostate Int (2015)

Forest plot of the relationship between downregulation of miRNA-145 level and disease-free survival in patients with prostate cancer. CI, confidence interval; HR, hazard ratio; miRNA, microRNA.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4588372&req=5

fig2: Forest plot of the relationship between downregulation of miRNA-145 level and disease-free survival in patients with prostate cancer. CI, confidence interval; HR, hazard ratio; miRNA, microRNA.
Mentions: As shown in Table 1, all four studies reported the HR and 95% CI directly. No heterogeneity was detected between the studies, as indicated by evaluation of the relationship between the reduced miR-145 level and DFS (I2 = 0.0%, P = 0.721). Therefore, a pooled HR and its 95% CI were calculated by use of a fixed-effects model. Forest plots of the individual HR estimates and the results of the meta-analysis are presented in Fig. 2. According to these results, lower levels of miR-145 expression were significantly predictive of poor DFS. The pooled HR was 0.74 (95% CI: 0.23–2.34, P = 0.001). Publication bias was evaluated by using funnel plots and Begg's tests. No significant publication biases were observed in this meta-analysis (P = 0.089; Fig. 3).

Bottom Line: Pooled hazard ratios of miR-145 and 95% confidence intervals were calculated.Four studies with a total of 211 patients were included in this meta-analysis.Thus, lower miR-145 expression was found to significantly predict poorer outcomes.

View Article: PubMed Central - PubMed

Affiliation: Shanxi Medical University, Taiyuan, China.

ABSTRACT

Background: Many studies have shown that microRNAs (miRNAs) exhibit altered expression in various cancers and may play an important role as prognostic biomarkers. The present meta-analysis was undertaken to summarize recent studies of the use of microRNA-145 (miR-145) in the assessment of prostate cancer and to analyze the prognostic role of miR-145 for disease-free survival (DFS) outcome.

Methods: The present meta-analysis was performed by searching PubMed with the use of multiple search strategies. Data were extracted from studies examining DFS in patients with prostate cancer who showed lower expression of miR-145. Pooled hazard ratios of miR-145 and 95% confidence intervals were calculated. Four studies with a total of 211 patients were included in this meta-analysis.

Results: For overall DFS, the pooled hazard ratio of lower miR-145 expression in prostate cancer was 0.74 (95% confidence interval: 0.23-2.34, P = 0.001). Thus, lower miR-145 expression was found to significantly predict poorer outcomes.

Conclusions: The present findings suggest that downregulation of the expression of miR-145 might predict poor prognosis in patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus