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Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions.

Suárez MF, Correa L, Crim N, Espósito E, Monti R, Urrets-Zavalía JA, Serra HM - Biomed Res Int (2015)

Bottom Line: CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection.No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection.No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection.

View Article: PubMed Central - PubMed

Affiliation: CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre esquina Medina Allende, 5000 Córdoba, Argentina.

ABSTRACT
Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the first time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.

No MeSH data available.


Related in: MedlinePlus

In vivo confocal microscopy showing oblique sections of the human cornea where the epithelium, Bowman's layer, and the anterior stroma can be observed. (a) Normal cornea without hyperreflective subepithelial deposits, (b) (grade 1) dot-like deposits at the level of Bowman's layer, (c) (level 2) showing an increase in the density of the hyperreflective dot-like deposits in Bowman layer and superficial stroma, and (d) (grade 3) hyperreflective and nonreflective condensation deposits in the Bowman layer and superficial stroma. Bar = 50 microns.
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fig2: In vivo confocal microscopy showing oblique sections of the human cornea where the epithelium, Bowman's layer, and the anterior stroma can be observed. (a) Normal cornea without hyperreflective subepithelial deposits, (b) (grade 1) dot-like deposits at the level of Bowman's layer, (c) (level 2) showing an increase in the density of the hyperreflective dot-like deposits in Bowman layer and superficial stroma, and (d) (grade 3) hyperreflective and nonreflective condensation deposits in the Bowman layer and superficial stroma. Bar = 50 microns.

Mentions: In Figure 2, IVCM oblique images of three representative patients with different grades of the disease clearly show the increase in hyperreflective dot-like deposits at the subepithelial layer as the disease progress.


Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions.

Suárez MF, Correa L, Crim N, Espósito E, Monti R, Urrets-Zavalía JA, Serra HM - Biomed Res Int (2015)

In vivo confocal microscopy showing oblique sections of the human cornea where the epithelium, Bowman's layer, and the anterior stroma can be observed. (a) Normal cornea without hyperreflective subepithelial deposits, (b) (grade 1) dot-like deposits at the level of Bowman's layer, (c) (level 2) showing an increase in the density of the hyperreflective dot-like deposits in Bowman layer and superficial stroma, and (d) (grade 3) hyperreflective and nonreflective condensation deposits in the Bowman layer and superficial stroma. Bar = 50 microns.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4588361&req=5

fig2: In vivo confocal microscopy showing oblique sections of the human cornea where the epithelium, Bowman's layer, and the anterior stroma can be observed. (a) Normal cornea without hyperreflective subepithelial deposits, (b) (grade 1) dot-like deposits at the level of Bowman's layer, (c) (level 2) showing an increase in the density of the hyperreflective dot-like deposits in Bowman layer and superficial stroma, and (d) (grade 3) hyperreflective and nonreflective condensation deposits in the Bowman layer and superficial stroma. Bar = 50 microns.
Mentions: In Figure 2, IVCM oblique images of three representative patients with different grades of the disease clearly show the increase in hyperreflective dot-like deposits at the subepithelial layer as the disease progress.

Bottom Line: CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection.No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection.No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection.

View Article: PubMed Central - PubMed

Affiliation: CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre esquina Medina Allende, 5000 Córdoba, Argentina.

ABSTRACT
Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the first time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.

No MeSH data available.


Related in: MedlinePlus