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Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions.

Suárez MF, Correa L, Crim N, Espósito E, Monti R, Urrets-Zavalía JA, Serra HM - Biomed Res Int (2015)

Bottom Line: CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection.No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection.No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection.

View Article: PubMed Central - PubMed

Affiliation: CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre esquina Medina Allende, 5000 Córdoba, Argentina.

ABSTRACT
Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the first time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.

No MeSH data available.


Related in: MedlinePlus

Map of the four regions included in this study.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Map of the four regions included in this study.

Mentions: Figure 1 shows the different regions studied.


Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions.

Suárez MF, Correa L, Crim N, Espósito E, Monti R, Urrets-Zavalía JA, Serra HM - Biomed Res Int (2015)

Map of the four regions included in this study.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4588361&req=5

fig1: Map of the four regions included in this study.
Mentions: Figure 1 shows the different regions studied.

Bottom Line: CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection.No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection.No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection.

View Article: PubMed Central - PubMed

Affiliation: CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre esquina Medina Allende, 5000 Córdoba, Argentina.

ABSTRACT
Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the first time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.

No MeSH data available.


Related in: MedlinePlus