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Construction of Zinc Oxide into Different Morphological Structures to Be Utilized as Antimicrobial Agent against Multidrug Resistant Bacteria.

Elkady MF, Shokry Hassan H, Hafez EE, Fouad A - Bioinorg Chem Appl (2015)

Bottom Line: Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques.The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g.Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

View Article: PubMed Central - PubMed

Affiliation: Fabrication Technology Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications, Alexandria 21934, Egypt ; Chemical and Petrochemical Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab City, Alexandria 21934, Egypt.

ABSTRACT
Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques. The variation of the different preparation parameters such as reaction temperature, time, and stabilizer agents was optimized to attain different morphological structures. The influence of the microwave annealing process on ZnO crystallinity, surface area, and morphological structure was monitored using XRD, BET, and SEM techniques, respectively. The antimicrobial activity of zinc oxide produced in nanotubes structure was examined against four different multidrug resistant bacteria: Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) strains. The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g. The minimum inhibitory concentration (MIC) of ZnO nanotubes showed that the low concentrations of ZnO nanotubes could be a substitution for the commercial antibiotics when approached in suitable formula. Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

No MeSH data available.


Related in: MedlinePlus

The influence of annealing process of zinc oxide on its antimicrobial activity against Bacillus subtilis using disc diffusion method. (a) As-prepared nanotube ZnO, (b) annealed ZnO at 500°C, (c) annealed ZnO at 700°C, and (d) annealed ZnO at 900°C.
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fig21: The influence of annealing process of zinc oxide on its antimicrobial activity against Bacillus subtilis using disc diffusion method. (a) As-prepared nanotube ZnO, (b) annealed ZnO at 500°C, (c) annealed ZnO at 700°C, and (d) annealed ZnO at 900°C.

Mentions: In order to elucidate the influence of the microwave annealing process of nanotube zinc oxide on antimicrobial activity, the annealed ZnO samples were examined against the Gram-positive (Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa) isolates at the optimum predetermined ZnO concentrations of 15 and 30 mg/mL. It was explored from Figures 21 and 22 that the annealing process of ZnO has negative impact on its antimicrobial activity for both Gram-positive and Gram-negative bacteria. Figure 21 indicated that the inhibition zones of ZnO against Bacillus subtilis decreased from ~22 mm for the as-prepared ZnO nanotubes to ~14 mm for the annealed sample at 500°C and these inhibition zones tend to be less than 5 mm for the annealed samples at 900°C. With respect to the Gram-negative strain (Pseudomonas aeruginosa), Figure 22 evidenced that the inhibitions zones decline from ~35 mm for the as-prepared nanotubes to ~21 mm for the annealed sample at 500°C and these inhibition zones tend to decline less than 10 mm for the annealed samples at 900°C. The depression at the inhibition zones of ZnO annealed samples compared with the as-prepared nanotube ZnO sample may be attributed to the decline at the material surface area after annealing which was proved previously as the action of the annealing temperature.


Construction of Zinc Oxide into Different Morphological Structures to Be Utilized as Antimicrobial Agent against Multidrug Resistant Bacteria.

Elkady MF, Shokry Hassan H, Hafez EE, Fouad A - Bioinorg Chem Appl (2015)

The influence of annealing process of zinc oxide on its antimicrobial activity against Bacillus subtilis using disc diffusion method. (a) As-prepared nanotube ZnO, (b) annealed ZnO at 500°C, (c) annealed ZnO at 700°C, and (d) annealed ZnO at 900°C.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4588359&req=5

fig21: The influence of annealing process of zinc oxide on its antimicrobial activity against Bacillus subtilis using disc diffusion method. (a) As-prepared nanotube ZnO, (b) annealed ZnO at 500°C, (c) annealed ZnO at 700°C, and (d) annealed ZnO at 900°C.
Mentions: In order to elucidate the influence of the microwave annealing process of nanotube zinc oxide on antimicrobial activity, the annealed ZnO samples were examined against the Gram-positive (Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa) isolates at the optimum predetermined ZnO concentrations of 15 and 30 mg/mL. It was explored from Figures 21 and 22 that the annealing process of ZnO has negative impact on its antimicrobial activity for both Gram-positive and Gram-negative bacteria. Figure 21 indicated that the inhibition zones of ZnO against Bacillus subtilis decreased from ~22 mm for the as-prepared ZnO nanotubes to ~14 mm for the annealed sample at 500°C and these inhibition zones tend to be less than 5 mm for the annealed samples at 900°C. With respect to the Gram-negative strain (Pseudomonas aeruginosa), Figure 22 evidenced that the inhibitions zones decline from ~35 mm for the as-prepared nanotubes to ~21 mm for the annealed sample at 500°C and these inhibition zones tend to decline less than 10 mm for the annealed samples at 900°C. The depression at the inhibition zones of ZnO annealed samples compared with the as-prepared nanotube ZnO sample may be attributed to the decline at the material surface area after annealing which was proved previously as the action of the annealing temperature.

Bottom Line: Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques.The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g.Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

View Article: PubMed Central - PubMed

Affiliation: Fabrication Technology Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications, Alexandria 21934, Egypt ; Chemical and Petrochemical Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab City, Alexandria 21934, Egypt.

ABSTRACT
Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques. The variation of the different preparation parameters such as reaction temperature, time, and stabilizer agents was optimized to attain different morphological structures. The influence of the microwave annealing process on ZnO crystallinity, surface area, and morphological structure was monitored using XRD, BET, and SEM techniques, respectively. The antimicrobial activity of zinc oxide produced in nanotubes structure was examined against four different multidrug resistant bacteria: Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) strains. The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g. The minimum inhibitory concentration (MIC) of ZnO nanotubes showed that the low concentrations of ZnO nanotubes could be a substitution for the commercial antibiotics when approached in suitable formula. Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

No MeSH data available.


Related in: MedlinePlus