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Construction of Zinc Oxide into Different Morphological Structures to Be Utilized as Antimicrobial Agent against Multidrug Resistant Bacteria.

Elkady MF, Shokry Hassan H, Hafez EE, Fouad A - Bioinorg Chem Appl (2015)

Bottom Line: Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques.The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g.Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

View Article: PubMed Central - PubMed

Affiliation: Fabrication Technology Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications, Alexandria 21934, Egypt ; Chemical and Petrochemical Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab City, Alexandria 21934, Egypt.

ABSTRACT
Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques. The variation of the different preparation parameters such as reaction temperature, time, and stabilizer agents was optimized to attain different morphological structures. The influence of the microwave annealing process on ZnO crystallinity, surface area, and morphological structure was monitored using XRD, BET, and SEM techniques, respectively. The antimicrobial activity of zinc oxide produced in nanotubes structure was examined against four different multidrug resistant bacteria: Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) strains. The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g. The minimum inhibitory concentration (MIC) of ZnO nanotubes showed that the low concentrations of ZnO nanotubes could be a substitution for the commercial antibiotics when approached in suitable formula. Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

No MeSH data available.


Related in: MedlinePlus

SEM micrographs of ZnO prepared using sol-gel technique with different reaction times: (a) 3 h, (b) 6 h, (c) 12 h, (d) 24 h, and (e) 48 h.
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fig8: SEM micrographs of ZnO prepared using sol-gel technique with different reaction times: (a) 3 h, (b) 6 h, (c) 12 h, (d) 24 h, and (e) 48 h.

Mentions: (ii) Morphological Structure (SEM). SEM images of the ZnO prepared at various reaction times were investigated in Figure 8. It is clear that the ZnO nanostructures depended on the growth time, where different morphological structures of nanoparticles and nanorods can be realized. For short growth periods of 3 hours (Figure 8(a)), aggregate nanorods structures are indicated. As the reaction period increased above 6 h, the nanorods disappeared and nanoparticles architecture morphology of ZnO can be achieved. However, for higher growth time, 6, 12, 24, and 48 h, nanoparticles structures have predominated. The suggested mechanism for ZnO may be considered as the ZnO nanorods structures are formed from the decomposition of Zn(OH)2 within 60 minutes' heating, after which the following time growth of the particles must result from dissolution and reprecipitation of the existing ZnO particles [39]. This is a slow process, as significant changes in the particle dimensions are only seen after 6 hours' ageing. As the reaction time increased above 6 hours, the formed nanorods structure of ZnO was converted to nanoparticles and nanoplates. That may be due to the increase in the stirring period of the formed ZnO nanoparticles after 6 h and destruction of the initial oriented growth chain of ZnO leading to particle formation from ZnO with hexagonal nanoparticle and nanoplates shapes. Consequently, the SEM results indicated that the optimum reaction time for ZnO nanorod formation with high degree of crystallinity and high aspect ratio was selected to be 3 hours.


Construction of Zinc Oxide into Different Morphological Structures to Be Utilized as Antimicrobial Agent against Multidrug Resistant Bacteria.

Elkady MF, Shokry Hassan H, Hafez EE, Fouad A - Bioinorg Chem Appl (2015)

SEM micrographs of ZnO prepared using sol-gel technique with different reaction times: (a) 3 h, (b) 6 h, (c) 12 h, (d) 24 h, and (e) 48 h.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4588359&req=5

fig8: SEM micrographs of ZnO prepared using sol-gel technique with different reaction times: (a) 3 h, (b) 6 h, (c) 12 h, (d) 24 h, and (e) 48 h.
Mentions: (ii) Morphological Structure (SEM). SEM images of the ZnO prepared at various reaction times were investigated in Figure 8. It is clear that the ZnO nanostructures depended on the growth time, where different morphological structures of nanoparticles and nanorods can be realized. For short growth periods of 3 hours (Figure 8(a)), aggregate nanorods structures are indicated. As the reaction period increased above 6 h, the nanorods disappeared and nanoparticles architecture morphology of ZnO can be achieved. However, for higher growth time, 6, 12, 24, and 48 h, nanoparticles structures have predominated. The suggested mechanism for ZnO may be considered as the ZnO nanorods structures are formed from the decomposition of Zn(OH)2 within 60 minutes' heating, after which the following time growth of the particles must result from dissolution and reprecipitation of the existing ZnO particles [39]. This is a slow process, as significant changes in the particle dimensions are only seen after 6 hours' ageing. As the reaction time increased above 6 hours, the formed nanorods structure of ZnO was converted to nanoparticles and nanoplates. That may be due to the increase in the stirring period of the formed ZnO nanoparticles after 6 h and destruction of the initial oriented growth chain of ZnO leading to particle formation from ZnO with hexagonal nanoparticle and nanoplates shapes. Consequently, the SEM results indicated that the optimum reaction time for ZnO nanorod formation with high degree of crystallinity and high aspect ratio was selected to be 3 hours.

Bottom Line: Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques.The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g.Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

View Article: PubMed Central - PubMed

Affiliation: Fabrication Technology Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications, Alexandria 21934, Egypt ; Chemical and Petrochemical Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab City, Alexandria 21934, Egypt.

ABSTRACT
Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques. The variation of the different preparation parameters such as reaction temperature, time, and stabilizer agents was optimized to attain different morphological structures. The influence of the microwave annealing process on ZnO crystallinity, surface area, and morphological structure was monitored using XRD, BET, and SEM techniques, respectively. The antimicrobial activity of zinc oxide produced in nanotubes structure was examined against four different multidrug resistant bacteria: Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) strains. The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m(2)/g. The minimum inhibitory concentration (MIC) of ZnO nanotubes showed that the low concentrations of ZnO nanotubes could be a substitution for the commercial antibiotics when approached in suitable formula. Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

No MeSH data available.


Related in: MedlinePlus