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Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.

Nishikawa S, Toshima T, Kobayashi M - PLoS ONE (2015)

Bottom Line: There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection.This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system.More such attempts should be made in order to clarify the links.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan; Phoenix Leader Education Program, Hiroshima University, Hiroshima City, Hiroshima, Japan.

ABSTRACT
This study examined changes in prefrontal oxy-Hb levels measured by NIRS (Near-Infrared Spectroscopy) during a facial-emotion recognition task in healthy adults, testing a mediational/moderational model of these variables. Fifty-three healthy adults (male = 35, female = 18) aged between 22 to 37 years old (mean age = 24.05 years old) provided saliva samples, completed a EMBU questionnaire (Swedish acronym for Egna Minnen Beträffande Uppfostran [My memories of upbringing]), and participated in a facial-emotion recognition task during NIRS recording. There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection. Finally, perceived parenting style played a mediating role in right frontal activation via the 5-HTTLPR genotype. Early-perceived parenting might influence neural activity in an uncertain situation i.e. rating ambiguous faces among individuals with certain genotypes. This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system. More such attempts should be made in order to clarify the links.

No MeSH data available.


Related in: MedlinePlus

Comparisons of high/low maternal rejection in right frontal oxy-Hb changes during ambiguous facial expression task within the same genotype group.Note: * p < .05.
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pone.0134685.g005: Comparisons of high/low maternal rejection in right frontal oxy-Hb changes during ambiguous facial expression task within the same genotype group.Note: * p < .05.

Mentions: A univariate F-test showed a significant gene × maternal rejection interaction on RoxH (F (1,50) = 4.84, η2 = .162, p = .012, power = .994), suggesting that individuals who carry the SL or LL genotype and with higher perceptions of rejection from their mothers had less right frontal activation compared to the SL/LL carriers with lower levels of perceived maternal rejection (see Fig 5). The interaction was not shown for paternal rejection (F (1,50) = .010, p = .921, η2 = .000, power = .051).


Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.

Nishikawa S, Toshima T, Kobayashi M - PLoS ONE (2015)

Comparisons of high/low maternal rejection in right frontal oxy-Hb changes during ambiguous facial expression task within the same genotype group.Note: * p < .05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587980&req=5

pone.0134685.g005: Comparisons of high/low maternal rejection in right frontal oxy-Hb changes during ambiguous facial expression task within the same genotype group.Note: * p < .05.
Mentions: A univariate F-test showed a significant gene × maternal rejection interaction on RoxH (F (1,50) = 4.84, η2 = .162, p = .012, power = .994), suggesting that individuals who carry the SL or LL genotype and with higher perceptions of rejection from their mothers had less right frontal activation compared to the SL/LL carriers with lower levels of perceived maternal rejection (see Fig 5). The interaction was not shown for paternal rejection (F (1,50) = .010, p = .921, η2 = .000, power = .051).

Bottom Line: There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection.This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system.More such attempts should be made in order to clarify the links.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan; Phoenix Leader Education Program, Hiroshima University, Hiroshima City, Hiroshima, Japan.

ABSTRACT
This study examined changes in prefrontal oxy-Hb levels measured by NIRS (Near-Infrared Spectroscopy) during a facial-emotion recognition task in healthy adults, testing a mediational/moderational model of these variables. Fifty-three healthy adults (male = 35, female = 18) aged between 22 to 37 years old (mean age = 24.05 years old) provided saliva samples, completed a EMBU questionnaire (Swedish acronym for Egna Minnen Beträffande Uppfostran [My memories of upbringing]), and participated in a facial-emotion recognition task during NIRS recording. There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection. Finally, perceived parenting style played a mediating role in right frontal activation via the 5-HTTLPR genotype. Early-perceived parenting might influence neural activity in an uncertain situation i.e. rating ambiguous faces among individuals with certain genotypes. This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system. More such attempts should be made in order to clarify the links.

No MeSH data available.


Related in: MedlinePlus