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Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.

Nishikawa S, Toshima T, Kobayashi M - PLoS ONE (2015)

Bottom Line: There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection.This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system.More such attempts should be made in order to clarify the links.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan; Phoenix Leader Education Program, Hiroshima University, Hiroshima City, Hiroshima, Japan.

ABSTRACT
This study examined changes in prefrontal oxy-Hb levels measured by NIRS (Near-Infrared Spectroscopy) during a facial-emotion recognition task in healthy adults, testing a mediational/moderational model of these variables. Fifty-three healthy adults (male = 35, female = 18) aged between 22 to 37 years old (mean age = 24.05 years old) provided saliva samples, completed a EMBU questionnaire (Swedish acronym for Egna Minnen Beträffande Uppfostran [My memories of upbringing]), and participated in a facial-emotion recognition task during NIRS recording. There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection. Finally, perceived parenting style played a mediating role in right frontal activation via the 5-HTTLPR genotype. Early-perceived parenting might influence neural activity in an uncertain situation i.e. rating ambiguous faces among individuals with certain genotypes. This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system. More such attempts should be made in order to clarify the links.

No MeSH data available.


Related in: MedlinePlus

Experimental design for NIRS recordings.
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pone.0134685.g002: Experimental design for NIRS recordings.

Mentions: Six hundred coloured images depicting four basic emotional expressions (happiness, surprise, anger, sadness) were used. We used standardized images that were developed using a morphing technique from database DB99 (Advanced Telecommunications Research Institute International, Inc, Nara, Japan, http://www.atr-p.com/products/face-db.html). These images have been used in prior studies, e.g. [6, 35]. We prepared one neutral and four emotional expressions from 50% (clear) to 35% (less clear) and 20% (ambiguous) in terms of expression clarity, by morphing photos of the women (see Fig 1). Each image was framed by an oval to avoid influences of hairstyle and clothing. One participant per session arrived at the laboratory and was seated in front of a computer with an NIRS recording device attached. The experimental setting is shown in Fig 2. The stimuli were presented in colour. One image was displayed at a time, centred on the monitor, with four expression descriptors (“happy”, “sad”, “angry” and “surprised”) displayed at the bottom (see Fig 3a & 3b). The participants were asked to click on the best description of the female expression in the centre of the screen. A neutral face without emotion was used for the baseline measurement. The participants were told to click on the text “I have no idea” if the expression was too difficult to rate. According to previous findings using the facial-emotional recognition task with both male and female faces [36], differences in the effects of male and female faces are relatively small. In order to simplify the task for the participants, we used only female faces in the present study.


Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.

Nishikawa S, Toshima T, Kobayashi M - PLoS ONE (2015)

Experimental design for NIRS recordings.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587980&req=5

pone.0134685.g002: Experimental design for NIRS recordings.
Mentions: Six hundred coloured images depicting four basic emotional expressions (happiness, surprise, anger, sadness) were used. We used standardized images that were developed using a morphing technique from database DB99 (Advanced Telecommunications Research Institute International, Inc, Nara, Japan, http://www.atr-p.com/products/face-db.html). These images have been used in prior studies, e.g. [6, 35]. We prepared one neutral and four emotional expressions from 50% (clear) to 35% (less clear) and 20% (ambiguous) in terms of expression clarity, by morphing photos of the women (see Fig 1). Each image was framed by an oval to avoid influences of hairstyle and clothing. One participant per session arrived at the laboratory and was seated in front of a computer with an NIRS recording device attached. The experimental setting is shown in Fig 2. The stimuli were presented in colour. One image was displayed at a time, centred on the monitor, with four expression descriptors (“happy”, “sad”, “angry” and “surprised”) displayed at the bottom (see Fig 3a & 3b). The participants were asked to click on the best description of the female expression in the centre of the screen. A neutral face without emotion was used for the baseline measurement. The participants were told to click on the text “I have no idea” if the expression was too difficult to rate. According to previous findings using the facial-emotional recognition task with both male and female faces [36], differences in the effects of male and female faces are relatively small. In order to simplify the task for the participants, we used only female faces in the present study.

Bottom Line: There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection.This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system.More such attempts should be made in order to clarify the links.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan; Phoenix Leader Education Program, Hiroshima University, Hiroshima City, Hiroshima, Japan.

ABSTRACT
This study examined changes in prefrontal oxy-Hb levels measured by NIRS (Near-Infrared Spectroscopy) during a facial-emotion recognition task in healthy adults, testing a mediational/moderational model of these variables. Fifty-three healthy adults (male = 35, female = 18) aged between 22 to 37 years old (mean age = 24.05 years old) provided saliva samples, completed a EMBU questionnaire (Swedish acronym for Egna Minnen Beträffande Uppfostran [My memories of upbringing]), and participated in a facial-emotion recognition task during NIRS recording. There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection. Finally, perceived parenting style played a mediating role in right frontal activation via the 5-HTTLPR genotype. Early-perceived parenting might influence neural activity in an uncertain situation i.e. rating ambiguous faces among individuals with certain genotypes. This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system. More such attempts should be made in order to clarify the links.

No MeSH data available.


Related in: MedlinePlus