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B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.

Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M - PLoS ONE (2015)

Bottom Line: We found that HBoV1-4-specific seroprevalences at age 6 years were 80%, 48%, 10%, and 0%, respectively.HBoV1 infections resulted in significantly weaker IgG responses among children who had pre-existing HBoV2 IgG, and vice versa.Our results strongly indicate that interactions between consecutive HBoV infections affect HBoV immunity via a phenomenon called "original antigenic sin", cross-protection, or both; however, without evident clinical consequences but with important ramifications for the serodiagnosis of HBoV infections.

View Article: PubMed Central - PubMed

Affiliation: University of Helsinki, Department of Virology, Helsinki, Finland.

ABSTRACT
Human bocaviruses (HBoVs) 1-4 are recently discovered, antigenically similar parvoviruses. We examined the hypothesis that the antigenic similarity of these viruses could give rise to clinically and diagnostically important immunological interactions. IgG and IgM EIAs as well as qPCR were used to study ~2000 sera collected from infancy to early adolescence at 3-6-month intervals from 109 children whose symptoms were recorded. We found that HBoV1-4-specific seroprevalences at age 6 years were 80%, 48%, 10%, and 0%, respectively. HBoV1 infections resulted in significantly weaker IgG responses among children who had pre-existing HBoV2 IgG, and vice versa. Furthermore, we documented a complete absence of virus type-specific immune responses in six viremic children who had pre-existing IgG for another bocavirus, indicating that not all HBoV infections can be diagnosed serologically. Our results strongly indicate that interactions between consecutive HBoV infections affect HBoV immunity via a phenomenon called "original antigenic sin", cross-protection, or both; however, without evident clinical consequences but with important ramifications for the serodiagnosis of HBoV infections. Serological data is likely to underestimate human exposure to these viruses.

No MeSH data available.


Related in: MedlinePlus

Human bocavirus 1–3 seroprevalences (dashed lines) and cumulative seroconversion rates (solid lines) in different age groups.
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pone.0139096.g001: Human bocavirus 1–3 seroprevalences (dashed lines) and cumulative seroconversion rates (solid lines) in different age groups.

Mentions: HBoV1-3 seroprevalences as a function of age are illustrated in Fig 1. Individual ELISA results of all 109 children are illustrated graphically in S1 Supporting Information. All children seroconverted for at least one HBoV by the age of 4.8 y. The median age of seroconversion for those who seroconverted within the follow-up, was 1.9 years (range 0.5–8.0) for HBoV1, 1.6 years (range 0.4–9.3) for HBoV2 and 1.7 years (range 0.4–5.8) for HBoV3. By the age of 6 years, among those 93 (85%) children who still remained in follow-up, the seroprevalences for HBoV1, 2 and 3 were 80%, 48% and 10%, respectively. No HBoV4 IgG was detected in any of the children.


B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.

Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M - PLoS ONE (2015)

Human bocavirus 1–3 seroprevalences (dashed lines) and cumulative seroconversion rates (solid lines) in different age groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587975&req=5

pone.0139096.g001: Human bocavirus 1–3 seroprevalences (dashed lines) and cumulative seroconversion rates (solid lines) in different age groups.
Mentions: HBoV1-3 seroprevalences as a function of age are illustrated in Fig 1. Individual ELISA results of all 109 children are illustrated graphically in S1 Supporting Information. All children seroconverted for at least one HBoV by the age of 4.8 y. The median age of seroconversion for those who seroconverted within the follow-up, was 1.9 years (range 0.5–8.0) for HBoV1, 1.6 years (range 0.4–9.3) for HBoV2 and 1.7 years (range 0.4–5.8) for HBoV3. By the age of 6 years, among those 93 (85%) children who still remained in follow-up, the seroprevalences for HBoV1, 2 and 3 were 80%, 48% and 10%, respectively. No HBoV4 IgG was detected in any of the children.

Bottom Line: We found that HBoV1-4-specific seroprevalences at age 6 years were 80%, 48%, 10%, and 0%, respectively.HBoV1 infections resulted in significantly weaker IgG responses among children who had pre-existing HBoV2 IgG, and vice versa.Our results strongly indicate that interactions between consecutive HBoV infections affect HBoV immunity via a phenomenon called "original antigenic sin", cross-protection, or both; however, without evident clinical consequences but with important ramifications for the serodiagnosis of HBoV infections.

View Article: PubMed Central - PubMed

Affiliation: University of Helsinki, Department of Virology, Helsinki, Finland.

ABSTRACT
Human bocaviruses (HBoVs) 1-4 are recently discovered, antigenically similar parvoviruses. We examined the hypothesis that the antigenic similarity of these viruses could give rise to clinically and diagnostically important immunological interactions. IgG and IgM EIAs as well as qPCR were used to study ~2000 sera collected from infancy to early adolescence at 3-6-month intervals from 109 children whose symptoms were recorded. We found that HBoV1-4-specific seroprevalences at age 6 years were 80%, 48%, 10%, and 0%, respectively. HBoV1 infections resulted in significantly weaker IgG responses among children who had pre-existing HBoV2 IgG, and vice versa. Furthermore, we documented a complete absence of virus type-specific immune responses in six viremic children who had pre-existing IgG for another bocavirus, indicating that not all HBoV infections can be diagnosed serologically. Our results strongly indicate that interactions between consecutive HBoV infections affect HBoV immunity via a phenomenon called "original antigenic sin", cross-protection, or both; however, without evident clinical consequences but with important ramifications for the serodiagnosis of HBoV infections. Serological data is likely to underestimate human exposure to these viruses.

No MeSH data available.


Related in: MedlinePlus