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Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries.

Yang SY, Huh IS, Baek JH, Cho EY, Choi MJ, Ryu S, Kim JS, Park T, Ha K, Hong KS - PLoS ONE (2015)

Bottom Line: Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped.Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group.Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.

ABSTRACT

Background: Findings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder (BD). After finding a linkage between the ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene) locus (15q26) and mixed families with schizophrenia and BD, several studies have reported a significant association between this gene and schizophrenia or BD. We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.

Methods: A total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.

Results: Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder (BD-I) groups. The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group (p = 0.0006, under the dominant model) remained significant after correcting for multiple testing.

Discussion: We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

No MeSH data available.


Related in: MedlinePlus

Association pattern between ST8SIA2 tag single nucleotide polymorphisms (SNPs) and schizophrenia and bipolar disorder under the dominant model.–Log of p-values are represented on the y-axis with relative location of the SNPs in the gene on the x-axis. Two horizontal lines indicate nominal and corrected p-values of 0.05.
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pone.0139413.g001: Association pattern between ST8SIA2 tag single nucleotide polymorphisms (SNPs) and schizophrenia and bipolar disorder under the dominant model.–Log of p-values are represented on the y-axis with relative location of the SNPs in the gene on the x-axis. Two horizontal lines indicate nominal and corrected p-values of 0.05.

Mentions: The overall SNP-disease association plot is shown in Fig 1, and the level of significance is shown as –log p-value. Schizophrenia and BD-I showed similar association trends throughout the region, and the association was stronger when schizophrenia and BD-I were analyzed together. But BD-II showed a different pattern with few association signals.


Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries.

Yang SY, Huh IS, Baek JH, Cho EY, Choi MJ, Ryu S, Kim JS, Park T, Ha K, Hong KS - PLoS ONE (2015)

Association pattern between ST8SIA2 tag single nucleotide polymorphisms (SNPs) and schizophrenia and bipolar disorder under the dominant model.–Log of p-values are represented on the y-axis with relative location of the SNPs in the gene on the x-axis. Two horizontal lines indicate nominal and corrected p-values of 0.05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587961&req=5

pone.0139413.g001: Association pattern between ST8SIA2 tag single nucleotide polymorphisms (SNPs) and schizophrenia and bipolar disorder under the dominant model.–Log of p-values are represented on the y-axis with relative location of the SNPs in the gene on the x-axis. Two horizontal lines indicate nominal and corrected p-values of 0.05.
Mentions: The overall SNP-disease association plot is shown in Fig 1, and the level of significance is shown as –log p-value. Schizophrenia and BD-I showed similar association trends throughout the region, and the association was stronger when schizophrenia and BD-I were analyzed together. But BD-II showed a different pattern with few association signals.

Bottom Line: Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped.Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group.Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.

ABSTRACT

Background: Findings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder (BD). After finding a linkage between the ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene) locus (15q26) and mixed families with schizophrenia and BD, several studies have reported a significant association between this gene and schizophrenia or BD. We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.

Methods: A total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.

Results: Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder (BD-I) groups. The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group (p = 0.0006, under the dominant model) remained significant after correcting for multiple testing.

Discussion: We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

No MeSH data available.


Related in: MedlinePlus