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Anti-diabetic effect of Capparis spinosa L. root extract in diabetic rats.

Kazemian M, Abad M, Haeri MR, Ebrahimi M, Heidari R - Avicenna J Phytomed (2015 Jul-Aug)

Bottom Line: Glucose levels significantly decreased after treating with plant extract (p=0.003).However, insulin levels did not increase in any treating groups.Plant extract could significantly raise HDL and reduce levels of LDL and liver enzymes (ALT and ALP).

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, University of Qom, Qom, Iran.

ABSTRACT

Objective: Diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. Reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. To our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. In the present study the effects of the C. spinosa root extract on diabetic metabolic disorders have been studied in experimental diabetes.

Materials and methods: Rats were divided into six groups: normal control (NC), diabetic control (DC), diabetic rats receiving 0.2, 0.4 g/kg of plant extract or 0.6 mg/kg glibenclamide (groups D0.2, D0.4 or DG respectively). A normal group of rats was also designed to receive 0.2 g/kg of plant extract (N0.2). Rats were rendered diabetic (streptozotocin 60 mg/kg, i.p.) and treated with 0.2, 0.4 g/ kg of plant extract or glibenclamide for four weeks. At the end of the experiment, blood was drawn through heart puncture under deep anesthesia. Weight was measured weekly, glucose levels were measured at the first and fourth week and lipid profiles, insulin and liver enzymes at the end of the study.

Results: Glucose levels significantly decreased after treating with plant extract (p=0.003). However, insulin levels did not increase in any treating groups. Plant extract could significantly raise HDL and reduce levels of LDL and liver enzymes (ALT and ALP).

Conclusion: These results showed that C. spinosa root extract could improve diabetic related metabolic derangement such as hyperglycemia, dyslipidemia, and elevated liver markers in an insulin-independent manner.

No MeSH data available.


Related in: MedlinePlus

Levels of serum lipids, LDL, HDL, cholesterol, and triacylglycerol. Data are expressed as mean±SD of measurements from 6 rats. Groups are labelled as follows: NC: normal control, DC: diabetic control, DG: diabetic rats treated with glybencelamide, D0.2 and D0.4: diabetic rats treated with 0.2 and 0.4 g/kg of hydro-alcoholic extract of the C. spinosa root and N0.2: normal control treated with 0.2 g/kg plant extract. *: p˂0.05 in comparison with DC
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Figure 4: Levels of serum lipids, LDL, HDL, cholesterol, and triacylglycerol. Data are expressed as mean±SD of measurements from 6 rats. Groups are labelled as follows: NC: normal control, DC: diabetic control, DG: diabetic rats treated with glybencelamide, D0.2 and D0.4: diabetic rats treated with 0.2 and 0.4 g/kg of hydro-alcoholic extract of the C. spinosa root and N0.2: normal control treated with 0.2 g/kg plant extract. *: p˂0.05 in comparison with DC

Mentions: After induction of diabetes, cholesterol significantly increased in DC (p<0.05) and decreased in D0.2, DG, and D0.4 as compared to DC (p=0.001, p<0.01 and p<0.05 respectively) (Figure 4).


Anti-diabetic effect of Capparis spinosa L. root extract in diabetic rats.

Kazemian M, Abad M, Haeri MR, Ebrahimi M, Heidari R - Avicenna J Phytomed (2015 Jul-Aug)

Levels of serum lipids, LDL, HDL, cholesterol, and triacylglycerol. Data are expressed as mean±SD of measurements from 6 rats. Groups are labelled as follows: NC: normal control, DC: diabetic control, DG: diabetic rats treated with glybencelamide, D0.2 and D0.4: diabetic rats treated with 0.2 and 0.4 g/kg of hydro-alcoholic extract of the C. spinosa root and N0.2: normal control treated with 0.2 g/kg plant extract. *: p˂0.05 in comparison with DC
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587611&req=5

Figure 4: Levels of serum lipids, LDL, HDL, cholesterol, and triacylglycerol. Data are expressed as mean±SD of measurements from 6 rats. Groups are labelled as follows: NC: normal control, DC: diabetic control, DG: diabetic rats treated with glybencelamide, D0.2 and D0.4: diabetic rats treated with 0.2 and 0.4 g/kg of hydro-alcoholic extract of the C. spinosa root and N0.2: normal control treated with 0.2 g/kg plant extract. *: p˂0.05 in comparison with DC
Mentions: After induction of diabetes, cholesterol significantly increased in DC (p<0.05) and decreased in D0.2, DG, and D0.4 as compared to DC (p=0.001, p<0.01 and p<0.05 respectively) (Figure 4).

Bottom Line: Glucose levels significantly decreased after treating with plant extract (p=0.003).However, insulin levels did not increase in any treating groups.Plant extract could significantly raise HDL and reduce levels of LDL and liver enzymes (ALT and ALP).

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, University of Qom, Qom, Iran.

ABSTRACT

Objective: Diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. Reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. To our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. In the present study the effects of the C. spinosa root extract on diabetic metabolic disorders have been studied in experimental diabetes.

Materials and methods: Rats were divided into six groups: normal control (NC), diabetic control (DC), diabetic rats receiving 0.2, 0.4 g/kg of plant extract or 0.6 mg/kg glibenclamide (groups D0.2, D0.4 or DG respectively). A normal group of rats was also designed to receive 0.2 g/kg of plant extract (N0.2). Rats were rendered diabetic (streptozotocin 60 mg/kg, i.p.) and treated with 0.2, 0.4 g/ kg of plant extract or glibenclamide for four weeks. At the end of the experiment, blood was drawn through heart puncture under deep anesthesia. Weight was measured weekly, glucose levels were measured at the first and fourth week and lipid profiles, insulin and liver enzymes at the end of the study.

Results: Glucose levels significantly decreased after treating with plant extract (p=0.003). However, insulin levels did not increase in any treating groups. Plant extract could significantly raise HDL and reduce levels of LDL and liver enzymes (ALT and ALP).

Conclusion: These results showed that C. spinosa root extract could improve diabetic related metabolic derangement such as hyperglycemia, dyslipidemia, and elevated liver markers in an insulin-independent manner.

No MeSH data available.


Related in: MedlinePlus