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Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats.

Kumar A, Kumar R, Rahman MS, Iqubal MA, Anand G, Niraj PK, Ali M - Avicenna J Phytomed (2015 Jul-Aug)

Bottom Line: The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility.The study concludes that Withania somnifera possesses phytoremedial effect.It is one of the best antidotes against arsenic-induced reproductive toxicity.

View Article: PubMed Central - PubMed

Affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.

ABSTRACT

Objective: The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology.

Materials and methods: In the present study, arsenic in the form of sodium arsenite was administered orally to male Charles Foster rats for 45 days. Thereafter, ethanolic root extract of Withania somnifera was administered for 30 days to observe its ameliorative effect on male reproductive system.

Results: The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility. However, after administration of Withania somnifera, there was significant reversal in the parameters denoting that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it.

Conclusion: The study concludes that Withania somnifera possesses phytoremedial effect. It is one of the best antidotes against arsenic-induced reproductive toxicity.

No MeSH data available.


Related in: MedlinePlus

Showing Luteinising hormone levels indifferent groups in which W.somnifera shows significant amelioration. The data are presented as mean ± S.D, n = 6, significance at p< 0.001.
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Figure 4: Showing Luteinising hormone levels indifferent groups in which W.somnifera shows significant amelioration. The data are presented as mean ± S.D, n = 6, significance at p< 0.001.

Mentions: The serum testosterone level showed decreased levels after arsenic exposure in comparison to control denoting the endocrine disruption while there was a significant increase in its level after administration of W.somnifera (p<0.001) denoting the normalization in the endocrine function (Figure 3). Whereas, there was an increase in the LH levels after arsenic exposure in comparison to control but there was as decrease in the LH levels (p<0.001) after administration of W.somnifera (Figure 4).


Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats.

Kumar A, Kumar R, Rahman MS, Iqubal MA, Anand G, Niraj PK, Ali M - Avicenna J Phytomed (2015 Jul-Aug)

Showing Luteinising hormone levels indifferent groups in which W.somnifera shows significant amelioration. The data are presented as mean ± S.D, n = 6, significance at p< 0.001.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587609&req=5

Figure 4: Showing Luteinising hormone levels indifferent groups in which W.somnifera shows significant amelioration. The data are presented as mean ± S.D, n = 6, significance at p< 0.001.
Mentions: The serum testosterone level showed decreased levels after arsenic exposure in comparison to control denoting the endocrine disruption while there was a significant increase in its level after administration of W.somnifera (p<0.001) denoting the normalization in the endocrine function (Figure 3). Whereas, there was an increase in the LH levels after arsenic exposure in comparison to control but there was as decrease in the LH levels (p<0.001) after administration of W.somnifera (Figure 4).

Bottom Line: The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility.The study concludes that Withania somnifera possesses phytoremedial effect.It is one of the best antidotes against arsenic-induced reproductive toxicity.

View Article: PubMed Central - PubMed

Affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.

ABSTRACT

Objective: The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology.

Materials and methods: In the present study, arsenic in the form of sodium arsenite was administered orally to male Charles Foster rats for 45 days. Thereafter, ethanolic root extract of Withania somnifera was administered for 30 days to observe its ameliorative effect on male reproductive system.

Results: The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility. However, after administration of Withania somnifera, there was significant reversal in the parameters denoting that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it.

Conclusion: The study concludes that Withania somnifera possesses phytoremedial effect. It is one of the best antidotes against arsenic-induced reproductive toxicity.

No MeSH data available.


Related in: MedlinePlus