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Effect of Malva sylvestris cream on burn injury and wounds in rats.

Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S - Avicenna J Phytomed (2015 Jul-Aug)

Bottom Line: The results of histology exhibited well-formed horizontally-oriented collagen fibers in MS topical treatment groups.M. sylvestris cream improved histological changes of tissue components in the process of healing when compared with SSD cream.Therefore, it can be used as a topical treatment agent for burn wound.

View Article: PubMed Central - PubMed

Affiliation: Traditional and Complementary Medicine Research Center, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Objectives: Burn injury is one of the most health-threatening problems in the world. Malva sylvestris (M. sylvestris) flowers have a high mucilage content and are used as a remedy for cut wound and dermal infected wounds in Iranian folklore Medicine. The purpose of this study was to investigate the effect of M. sylvestris cream on the second degree burn injury in rats.

Materials and methods: Five groups of 10 rats per group were burned with hot metal plate. Animals were administrated divided as control, normal saline, standard silver sulfadiazine 1% (SSD), 5% M. sylvestris, and 10% M. sylvestris into separate groups. Wound area, percentage of wound contraction, and histological and bacteriological assessments were evaluated.

Results: Wound sizes were not significantly different among groups on 1(st) and 3(rd) days after burn injury, while they were significantly different among groups after 7(th) day post-burn injury. The average areas of wounds on the 15(th) day were 7.5±2.9, 6.7±2, 10.5±1.6, 4.7±2, and 4.5±2 cm(2) for base cream, normal saline, SSD, 5% M. sylvestris, and 10% M. sylvestris, respectively. The results of histology exhibited well-formed horizontally-oriented collagen fibers in MS topical treatment groups. Microorganisms existed in the SSD group were most probably Staphilococcus epidermitis and for NS group were staphylococcus saprophiteccus.

Conclusion: M. sylvestris cream improved histological changes of tissue components in the process of healing when compared with SSD cream. Therefore, it can be used as a topical treatment agent for burn wound.

No MeSH data available.


Related in: MedlinePlus

Burn wound healing pattern in control groups [normal saline (NS), base cream (BC), andsilver sulfadiazine 1% (SSD1%)] and herbal treated groups [M.sylvestris cream 5% and 10% (MS 5%,MS 10%)] in rats. The rate of healing inburn wounds created on rats were measured and photographed at regular intervals in bothcontrol groups and herbal treated rats during a 25-day period. Wound healing conditionin (MS 10%) and MS 5% from ten rats were completed on 25 days
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Figure 2: Burn wound healing pattern in control groups [normal saline (NS), base cream (BC), andsilver sulfadiazine 1% (SSD1%)] and herbal treated groups [M.sylvestris cream 5% and 10% (MS 5%,MS 10%)] in rats. The rate of healing inburn wounds created on rats were measured and photographed at regular intervals in bothcontrol groups and herbal treated rats during a 25-day period. Wound healing conditionin (MS 10%) and MS 5% from ten rats were completed on 25 days

Mentions: The percentage of wound contractions in different groups is shown in Table 5. It was significantly increased in 10% M.sylvestris group as compared to the SSD and control groups. Animals who receivedherbal treatment creams had a shorter healing time than rats in all control groups (Figure 2). Wound contraction started from day 4 intreatment group and day 5 in control groups. On day 7, animals treated with 10% M.sylvestris exhibited significant increase in the percentage of wound contractionas compared to other experimental groups. On day 20 of post-burn injury, 10% and 5%M. sylvestris creams exhibited more than 90% wound healing, whereas itwas 63% , 65.1%, and 61.5% in rats treated with BC, NS, and SSD creams, respectively. On day25, no scar was observed in animals treated with 10% and 5% M. sylvestris,while this improvement was observed for control groups on day 30. The time of wound healingin the herbal treatment group was about 10 days shorter than the SSD group. The herbalgroups were treated 5-7 days faster than the BC group (Table5 and Figure 3).


Effect of Malva sylvestris cream on burn injury and wounds in rats.

Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S - Avicenna J Phytomed (2015 Jul-Aug)

Burn wound healing pattern in control groups [normal saline (NS), base cream (BC), andsilver sulfadiazine 1% (SSD1%)] and herbal treated groups [M.sylvestris cream 5% and 10% (MS 5%,MS 10%)] in rats. The rate of healing inburn wounds created on rats were measured and photographed at regular intervals in bothcontrol groups and herbal treated rats during a 25-day period. Wound healing conditionin (MS 10%) and MS 5% from ten rats were completed on 25 days
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587603&req=5

Figure 2: Burn wound healing pattern in control groups [normal saline (NS), base cream (BC), andsilver sulfadiazine 1% (SSD1%)] and herbal treated groups [M.sylvestris cream 5% and 10% (MS 5%,MS 10%)] in rats. The rate of healing inburn wounds created on rats were measured and photographed at regular intervals in bothcontrol groups and herbal treated rats during a 25-day period. Wound healing conditionin (MS 10%) and MS 5% from ten rats were completed on 25 days
Mentions: The percentage of wound contractions in different groups is shown in Table 5. It was significantly increased in 10% M.sylvestris group as compared to the SSD and control groups. Animals who receivedherbal treatment creams had a shorter healing time than rats in all control groups (Figure 2). Wound contraction started from day 4 intreatment group and day 5 in control groups. On day 7, animals treated with 10% M.sylvestris exhibited significant increase in the percentage of wound contractionas compared to other experimental groups. On day 20 of post-burn injury, 10% and 5%M. sylvestris creams exhibited more than 90% wound healing, whereas itwas 63% , 65.1%, and 61.5% in rats treated with BC, NS, and SSD creams, respectively. On day25, no scar was observed in animals treated with 10% and 5% M. sylvestris,while this improvement was observed for control groups on day 30. The time of wound healingin the herbal treatment group was about 10 days shorter than the SSD group. The herbalgroups were treated 5-7 days faster than the BC group (Table5 and Figure 3).

Bottom Line: The results of histology exhibited well-formed horizontally-oriented collagen fibers in MS topical treatment groups.M. sylvestris cream improved histological changes of tissue components in the process of healing when compared with SSD cream.Therefore, it can be used as a topical treatment agent for burn wound.

View Article: PubMed Central - PubMed

Affiliation: Traditional and Complementary Medicine Research Center, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Objectives: Burn injury is one of the most health-threatening problems in the world. Malva sylvestris (M. sylvestris) flowers have a high mucilage content and are used as a remedy for cut wound and dermal infected wounds in Iranian folklore Medicine. The purpose of this study was to investigate the effect of M. sylvestris cream on the second degree burn injury in rats.

Materials and methods: Five groups of 10 rats per group were burned with hot metal plate. Animals were administrated divided as control, normal saline, standard silver sulfadiazine 1% (SSD), 5% M. sylvestris, and 10% M. sylvestris into separate groups. Wound area, percentage of wound contraction, and histological and bacteriological assessments were evaluated.

Results: Wound sizes were not significantly different among groups on 1(st) and 3(rd) days after burn injury, while they were significantly different among groups after 7(th) day post-burn injury. The average areas of wounds on the 15(th) day were 7.5±2.9, 6.7±2, 10.5±1.6, 4.7±2, and 4.5±2 cm(2) for base cream, normal saline, SSD, 5% M. sylvestris, and 10% M. sylvestris, respectively. The results of histology exhibited well-formed horizontally-oriented collagen fibers in MS topical treatment groups. Microorganisms existed in the SSD group were most probably Staphilococcus epidermitis and for NS group were staphylococcus saprophiteccus.

Conclusion: M. sylvestris cream improved histological changes of tissue components in the process of healing when compared with SSD cream. Therefore, it can be used as a topical treatment agent for burn wound.

No MeSH data available.


Related in: MedlinePlus