Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound.
Bottom Line: Current drug delivery relies on systemic delivery or injections into the joint.Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment strategies.In conclusion, we identify intense megahertz ultrasound as a technique that potentially enables localized non-destructive delivery of osteoarthritis drugs or drug carriers into articular cartilage.
Affiliation: Department of Physics, University of Helsinki, Helsinki, Finland. Electronic address: firstname.lastname@example.org.Show MeSH
Related in: MedlinePlus
Mentions: Histologic evaluation of ultrasound-treated AC samples (6a–9a) and control samples (6b–9b) revealed no difference between the groups with respect to superficial tissue fibrillation or collagen (blue contrast in Masson's trichrome-stained sections) or proteoglycan (red contrast in Safranin-O-stained sections) distribution (Fig. 6).
Affiliation: Department of Physics, University of Helsinki, Helsinki, Finland. Electronic address: email@example.com.