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Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound.

Nieminen HJ, Ylitalo T, Suuronen JP, Rahunen K, Salmi A, Saarakkala S, Serimaa R, Hæggström E - Ultrasound Med Biol (2015)

Bottom Line: Current drug delivery relies on systemic delivery or injections into the joint.Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment strategies.In conclusion, we identify intense megahertz ultrasound as a technique that potentially enables localized non-destructive delivery of osteoarthritis drugs or drug carriers into articular cartilage.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, University of Helsinki, Helsinki, Finland. Electronic address: heikki.nieminen@helsinki.fi.

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Related in: MedlinePlus

Penetration depths. Penetration depths (mean ± standard deviation) at sample center (treatment) compared with adjacent tissue (control) (Fig. 3). The samples were immersed in phosphotungstic acid (PTA) + phosphate-buffered saline (PBS) solution, while sonicated with intense megahertz ultrasound.
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fig5: Penetration depths. Penetration depths (mean ± standard deviation) at sample center (treatment) compared with adjacent tissue (control) (Fig. 3). The samples were immersed in phosphotungstic acid (PTA) + phosphate-buffered saline (PBS) solution, while sonicated with intense megahertz ultrasound.

Mentions: The delivery depths for samples 2–5 (immersed in PTA + PBS solution while sonicated) are summarized in Table 1 and Figures 4 and 5. For these samples, the average penetration depth of PTA at the treatment area was 2.6 times the penetration depth in the control tissue (Fig. 5). For samples with strong PTA penetration at the sample center, that is, samples 2, 3 and 5, the maximum penetration depths were 775, 883 and 754 μm, respectively (Fig. 4), corresponding to a relative penetration of 53 ± 4% and an average penetration speed of 322 μm/h. Sample 4 appeared to exhibit strong passive PTA diffusion outside the ultrasound beam; nevertheless, a circular PTA penetration pattern is seen at the location of the ultrasound beam, that is, sample center (Fig. 4f). Subchondral bone temperature remained below 33°C (n = 3).


Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound.

Nieminen HJ, Ylitalo T, Suuronen JP, Rahunen K, Salmi A, Saarakkala S, Serimaa R, Hæggström E - Ultrasound Med Biol (2015)

Penetration depths. Penetration depths (mean ± standard deviation) at sample center (treatment) compared with adjacent tissue (control) (Fig. 3). The samples were immersed in phosphotungstic acid (PTA) + phosphate-buffered saline (PBS) solution, while sonicated with intense megahertz ultrasound.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4587538&req=5

fig5: Penetration depths. Penetration depths (mean ± standard deviation) at sample center (treatment) compared with adjacent tissue (control) (Fig. 3). The samples were immersed in phosphotungstic acid (PTA) + phosphate-buffered saline (PBS) solution, while sonicated with intense megahertz ultrasound.
Mentions: The delivery depths for samples 2–5 (immersed in PTA + PBS solution while sonicated) are summarized in Table 1 and Figures 4 and 5. For these samples, the average penetration depth of PTA at the treatment area was 2.6 times the penetration depth in the control tissue (Fig. 5). For samples with strong PTA penetration at the sample center, that is, samples 2, 3 and 5, the maximum penetration depths were 775, 883 and 754 μm, respectively (Fig. 4), corresponding to a relative penetration of 53 ± 4% and an average penetration speed of 322 μm/h. Sample 4 appeared to exhibit strong passive PTA diffusion outside the ultrasound beam; nevertheless, a circular PTA penetration pattern is seen at the location of the ultrasound beam, that is, sample center (Fig. 4f). Subchondral bone temperature remained below 33°C (n = 3).

Bottom Line: Current drug delivery relies on systemic delivery or injections into the joint.Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment strategies.In conclusion, we identify intense megahertz ultrasound as a technique that potentially enables localized non-destructive delivery of osteoarthritis drugs or drug carriers into articular cartilage.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, University of Helsinki, Helsinki, Finland. Electronic address: heikki.nieminen@helsinki.fi.

Show MeSH
Related in: MedlinePlus