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The Significance of Serum CA-125 Elevation in Chinese Patients with Primary Budd-Chiari Syndrome: A Multicenter Study.

Cheng DL, Xu H, Lv WF, Hua R, Du H, Zhang QQ - Gastroenterol Res Pract (2015)

Bottom Line: Results.Serum CA-125 was significantly elevated in BCS patients compared to healthy volunteers (P < 0.001).Serum CA-125 levels significantly correlated with ascites volume, serum level of alanine aminotransferase, aspartate aminotransferase, albumin, and Rotterdam BCS scores.

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Radiology, Anhui Provincial Hospital, Hefei, Anhui 230001, China.

ABSTRACT
Objective. To investigate the serum level of CA-125 and its corresponding clinical significance in Chinese patients with primary BCS. Methods. Serum CA-125 was measured in 243 patients with primary BCS receiving interventional treatment in the participating hospitals and in 120 healthy volunteers. The correlation between serum CA-125 levels and ascites volume, liver function, and prognosis was analyzed. Results. Serum CA-125 was significantly elevated in BCS patients compared to healthy volunteers (P < 0.001). Higher levels of CA-125 were found in BCS patients with abnormal hepatic function and low serum albumin levels and in patients with high volume of ascites compared to patients without these abnormalities. Serum CA-125 levels significantly correlated with ascites volume, serum level of alanine aminotransferase, aspartate aminotransferase, albumin, and Rotterdam BCS scores. The follow-up study indicated that the survival rate and asymptomatic survival rate after interventional treatment were lower in BCS patients with serum CA-125 > 175 U/mL (P < 0.05). Conclusion. Serum CA-125 was significantly higher in patients with primary BCS and had a positive correlation with the volume of ascites, severity of liver damage, and poor prognosis. Thus the serum CA-125 levels may be used to estimate the severity and prognosis of BCS in Chinese patients.

No MeSH data available.


Related in: MedlinePlus

Survival rate curve after interventional treatment of Budd-Chiari syndrome patients with different serum CA-125.
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fig2: Survival rate curve after interventional treatment of Budd-Chiari syndrome patients with different serum CA-125.

Mentions: For eight patients, interventional treatment failed due to inaccessibility of the target vein for long-segment occlusion. Therefore they were only treated with medicine (i.e., diuretic drugs, hydrochlorothiazide). The other 235 (96.7%) patients were treated with interventional methods (angioplasty in 223 cases; TIPS in 12 cases), and the technical success rate was 96.7%. Of these 235 patients, serum CA-125 was five times higher than the upper limit of normal range (>175 U/mL) in 68 patients, who were classified as high CA-125 group while the other 167 patients were classified into lower CA-125 group. The survival rate and asymptomatic survival rate after interventional treatment were significantly lower (P < 0.05) for patients in high CA-125 group (95.6% (95% CI: 90.7%–98.9%) and 79.8% (95% CI: 69.5%–90.1%)), in comparison with the lower CA-125 group (98.8% (95% CI: 96.4%–99.9%) and 92.0% (95% CI: 86.5%–97.5%)) (Table 4, Figures 2(a) and 2(b)).


The Significance of Serum CA-125 Elevation in Chinese Patients with Primary Budd-Chiari Syndrome: A Multicenter Study.

Cheng DL, Xu H, Lv WF, Hua R, Du H, Zhang QQ - Gastroenterol Res Pract (2015)

Survival rate curve after interventional treatment of Budd-Chiari syndrome patients with different serum CA-125.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4587407&req=5

fig2: Survival rate curve after interventional treatment of Budd-Chiari syndrome patients with different serum CA-125.
Mentions: For eight patients, interventional treatment failed due to inaccessibility of the target vein for long-segment occlusion. Therefore they were only treated with medicine (i.e., diuretic drugs, hydrochlorothiazide). The other 235 (96.7%) patients were treated with interventional methods (angioplasty in 223 cases; TIPS in 12 cases), and the technical success rate was 96.7%. Of these 235 patients, serum CA-125 was five times higher than the upper limit of normal range (>175 U/mL) in 68 patients, who were classified as high CA-125 group while the other 167 patients were classified into lower CA-125 group. The survival rate and asymptomatic survival rate after interventional treatment were significantly lower (P < 0.05) for patients in high CA-125 group (95.6% (95% CI: 90.7%–98.9%) and 79.8% (95% CI: 69.5%–90.1%)), in comparison with the lower CA-125 group (98.8% (95% CI: 96.4%–99.9%) and 92.0% (95% CI: 86.5%–97.5%)) (Table 4, Figures 2(a) and 2(b)).

Bottom Line: Results.Serum CA-125 was significantly elevated in BCS patients compared to healthy volunteers (P < 0.001).Serum CA-125 levels significantly correlated with ascites volume, serum level of alanine aminotransferase, aspartate aminotransferase, albumin, and Rotterdam BCS scores.

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Radiology, Anhui Provincial Hospital, Hefei, Anhui 230001, China.

ABSTRACT
Objective. To investigate the serum level of CA-125 and its corresponding clinical significance in Chinese patients with primary BCS. Methods. Serum CA-125 was measured in 243 patients with primary BCS receiving interventional treatment in the participating hospitals and in 120 healthy volunteers. The correlation between serum CA-125 levels and ascites volume, liver function, and prognosis was analyzed. Results. Serum CA-125 was significantly elevated in BCS patients compared to healthy volunteers (P < 0.001). Higher levels of CA-125 were found in BCS patients with abnormal hepatic function and low serum albumin levels and in patients with high volume of ascites compared to patients without these abnormalities. Serum CA-125 levels significantly correlated with ascites volume, serum level of alanine aminotransferase, aspartate aminotransferase, albumin, and Rotterdam BCS scores. The follow-up study indicated that the survival rate and asymptomatic survival rate after interventional treatment were lower in BCS patients with serum CA-125 > 175 U/mL (P < 0.05). Conclusion. Serum CA-125 was significantly higher in patients with primary BCS and had a positive correlation with the volume of ascites, severity of liver damage, and poor prognosis. Thus the serum CA-125 levels may be used to estimate the severity and prognosis of BCS in Chinese patients.

No MeSH data available.


Related in: MedlinePlus