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Cryo-recanalization in a case of carcinoid tumor - An interesting case report.

Chawla RK, Madan A, Chawla A, Arora HN - Lung India (2015 Sep-Oct)

Bottom Line: In the past, these tumors were grouped with benign or less aggressive malignant pulmonary tumors, namely bronchial adenomas.Recent studies have revealed that carcinoid lung tumors are the most indolent form of a spectrum of bronchopulmonary neuroendocrine tumors that, at its extreme, include small cell carcinoma of the lung as its most malignant member.They commonly present as endobronchial obstructions, and if complete, can be life-threatening and require immediate intervention.[1] Recently, we have treated a patient of carcinoid tumor of lung who was managed with cryo-recanalization with excellent response.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Critical Care and Sleep Disorders, Jaipur Golden Hospital, Delhi, India.

ABSTRACT
The term "cryotherapy" comes from the Greek cryo (κρύο) meaning cold, and therapy (θεραπεία) meaning cure. Cryosurgery is the application of extreme cold to destroy abnormal or diseased tissue. Carcinoid tumors of the lung are a fascinating but uncommon group of pulmonary neoplasms. In the past, these tumors were grouped with benign or less aggressive malignant pulmonary tumors, namely bronchial adenomas. Recent studies have revealed that carcinoid lung tumors are the most indolent form of a spectrum of bronchopulmonary neuroendocrine tumors that, at its extreme, include small cell carcinoma of the lung as its most malignant member. They commonly present as endobronchial obstructions, and if complete, can be life-threatening and require immediate intervention.[1] Recently, we have treated a patient of carcinoid tumor of lung who was managed with cryo-recanalization with excellent response.

No MeSH data available.


Related in: MedlinePlus

Bronchoscopic view of pedunculated growth in LMB with Cryo-Probe
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Figure 4: Bronchoscopic view of pedunculated growth in LMB with Cryo-Probe

Mentions: Fibreoptic bronchoscopy was performed which showed endobronchial pedunculated growth in left main bronchus, [Figure 4], Bronchoscope could not be negotiated beyond the growth. Endobronchial biopsy was taken from the growth with minimal bleeding. Histopathology report revealed nonspecific inflammation. Video bronchoscopy guided cryo-biopsy was done for histopathology, which revealed neuroendocrine tumor Grade 1 [Figure 5]. IHC revealed tumor cells expressing synaptophysin and chromogranin. Cytokeratin expression is granular moderate intensity. Ki67 proliferation index <1% and negative for TTF 1. It was consistent with typical carcinoid tumor (neuroendocrine tumor Grade 1). Patient was planned for cryo-recanalization.


Cryo-recanalization in a case of carcinoid tumor - An interesting case report.

Chawla RK, Madan A, Chawla A, Arora HN - Lung India (2015 Sep-Oct)

Bronchoscopic view of pedunculated growth in LMB with Cryo-Probe
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4587013&req=5

Figure 4: Bronchoscopic view of pedunculated growth in LMB with Cryo-Probe
Mentions: Fibreoptic bronchoscopy was performed which showed endobronchial pedunculated growth in left main bronchus, [Figure 4], Bronchoscope could not be negotiated beyond the growth. Endobronchial biopsy was taken from the growth with minimal bleeding. Histopathology report revealed nonspecific inflammation. Video bronchoscopy guided cryo-biopsy was done for histopathology, which revealed neuroendocrine tumor Grade 1 [Figure 5]. IHC revealed tumor cells expressing synaptophysin and chromogranin. Cytokeratin expression is granular moderate intensity. Ki67 proliferation index <1% and negative for TTF 1. It was consistent with typical carcinoid tumor (neuroendocrine tumor Grade 1). Patient was planned for cryo-recanalization.

Bottom Line: In the past, these tumors were grouped with benign or less aggressive malignant pulmonary tumors, namely bronchial adenomas.Recent studies have revealed that carcinoid lung tumors are the most indolent form of a spectrum of bronchopulmonary neuroendocrine tumors that, at its extreme, include small cell carcinoma of the lung as its most malignant member.They commonly present as endobronchial obstructions, and if complete, can be life-threatening and require immediate intervention.[1] Recently, we have treated a patient of carcinoid tumor of lung who was managed with cryo-recanalization with excellent response.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Critical Care and Sleep Disorders, Jaipur Golden Hospital, Delhi, India.

ABSTRACT
The term "cryotherapy" comes from the Greek cryo (κρύο) meaning cold, and therapy (θεραπεία) meaning cure. Cryosurgery is the application of extreme cold to destroy abnormal or diseased tissue. Carcinoid tumors of the lung are a fascinating but uncommon group of pulmonary neoplasms. In the past, these tumors were grouped with benign or less aggressive malignant pulmonary tumors, namely bronchial adenomas. Recent studies have revealed that carcinoid lung tumors are the most indolent form of a spectrum of bronchopulmonary neuroendocrine tumors that, at its extreme, include small cell carcinoma of the lung as its most malignant member. They commonly present as endobronchial obstructions, and if complete, can be life-threatening and require immediate intervention.[1] Recently, we have treated a patient of carcinoid tumor of lung who was managed with cryo-recanalization with excellent response.

No MeSH data available.


Related in: MedlinePlus