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Medical genetics and genomic medicine in Greece: achievements and challenges.

Manoli I, Fryssira H - Mol Genet Genomic Med (2015)

View Article: PubMed Central - PubMed

Affiliation: Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, Maryland.

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The concern about the lineage of the tragic figures in Greek drama and the theories on heredity and procreation expressed by the ancient physicians and philosophers helped influence the development of genetics for many centuries... Scientific evidence for patterns of genetic inheritance did not appear until Mendel’s work... Cytogenetics departments in two of the main University hospitals in Athens, the “Aghia Sophia” Childrens’ Hospital and the “Alexandra” Maternity Hospital were the first to offer genetic services in the early 1960s... The Institute of Child Health was founded in 1965 as a diagnostic laboratory for metabolic disorders... The Department of Medical Genetics (DMG) at the Choremion Research Laboratory of the First Department of Pediatrics of the University of Athens has the leading role in introducing modern molecular genetics methods for the diagnosis, carrier screening, and prenatal diagnosis of most genetic disorders in Greece... Annually these include (approximately):5000 samples for laboratory analysis 5000 cases for clinical evaluation and/or counseling The genetic services include:Clinical genetics and dysmorphology as an outpatient clinic offers: Patient evaluation (diagnosis, prognosis, prevention, and risk assessment) Genetic counseling Our well-equipped Genetics Laboratory provides: Molecular genetics Cytogenetics (pre- and postnatal) Molecular cytogenetics (pre- and postnatal) Prenatal diagnosis (monogenic diseases and karyotype) Preimplantation genetic diagnosis Noninvasive prenatal diagnosis (sex and rhesus) Microarrays technologies for CGH (Comperative Genomic Hybridization) and expression studies Concurrent to the major role that the DMG plays in clinical services, it has also made substantial contributions in several areas of applied research in the field of genetics... There are over 24 public and private institutions currently offering a variety of genetic services in Greece, with ∼17 entries for molecular DNA diagnostic laboratories in the European Directory of DNA Diagnostic Laboratories (EDDNAL) website... Greece has played a pioneer role in the field of hemoglobinopathies, both in the diagnosis, clinical management, therapeutic trials, prenatal diagnosis, and research, while the National Thalassemia Prevention Program has effectively decreased the incidence of thalassemia major and sickle cell (SC) syndromes in Greece... Based on the annual rates over the past 35 years, ∼12,000 couples at risk have had a healthy child... The program has managed to significantly reduce the number of new cases of thalassemia major and direct the available resources toward the optimization of treatment of the surviving patients (Voskaridou et al. )... It is important to separate them from another group, named “Gypsies,” that appeared in Greece in the ninth century through Egypt... Significant difficulties in access to healthcare services by both these minorities, result from the fact that the majority of these populations do not have identity or citizenship documents and they travel frequently... All these groups cooperate with professional medical staff... In 1982, the Hellenic Association of Medical Geneticists was founded and consisted of professionals working in the field of medical genetics... A major aim of the Greek genetics community is to have Clinical Genetics recognized as an independent Medical Specialty in Greece.

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Map of Greece (Source: United Nations).
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fig01: Map of Greece (Source: United Nations).

Mentions: Greece (also known as Hellas) is located in southeastern Europe and is bordered on the north by Albania, the Former Yugoslav Republic of Macedonia (F.Y.R.O.M.) and Bulgaria; on the east by the Aegean Sea and Turkey; and on the west and south by the Ionian and Mediterranean seas, respectively. The country consists of the mainland, the Peloponnese peninsula and more than 3000 islands, of which about 170 are inhabited, including Crete, Rhodes, and Corfu, and the Ionian, Dodecanese, and Cyclades groups (Fig.1).


Medical genetics and genomic medicine in Greece: achievements and challenges.

Manoli I, Fryssira H - Mol Genet Genomic Med (2015)

Map of Greece (Source: United Nations).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585445&req=5

fig01: Map of Greece (Source: United Nations).
Mentions: Greece (also known as Hellas) is located in southeastern Europe and is bordered on the north by Albania, the Former Yugoslav Republic of Macedonia (F.Y.R.O.M.) and Bulgaria; on the east by the Aegean Sea and Turkey; and on the west and south by the Ionian and Mediterranean seas, respectively. The country consists of the mainland, the Peloponnese peninsula and more than 3000 islands, of which about 170 are inhabited, including Crete, Rhodes, and Corfu, and the Ionian, Dodecanese, and Cyclades groups (Fig.1).

View Article: PubMed Central - PubMed

Affiliation: Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, Maryland.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The concern about the lineage of the tragic figures in Greek drama and the theories on heredity and procreation expressed by the ancient physicians and philosophers helped influence the development of genetics for many centuries... Scientific evidence for patterns of genetic inheritance did not appear until Mendel’s work... Cytogenetics departments in two of the main University hospitals in Athens, the “Aghia Sophia” Childrens’ Hospital and the “Alexandra” Maternity Hospital were the first to offer genetic services in the early 1960s... The Institute of Child Health was founded in 1965 as a diagnostic laboratory for metabolic disorders... The Department of Medical Genetics (DMG) at the Choremion Research Laboratory of the First Department of Pediatrics of the University of Athens has the leading role in introducing modern molecular genetics methods for the diagnosis, carrier screening, and prenatal diagnosis of most genetic disorders in Greece... Annually these include (approximately):5000 samples for laboratory analysis 5000 cases for clinical evaluation and/or counseling The genetic services include:Clinical genetics and dysmorphology as an outpatient clinic offers: Patient evaluation (diagnosis, prognosis, prevention, and risk assessment) Genetic counseling Our well-equipped Genetics Laboratory provides: Molecular genetics Cytogenetics (pre- and postnatal) Molecular cytogenetics (pre- and postnatal) Prenatal diagnosis (monogenic diseases and karyotype) Preimplantation genetic diagnosis Noninvasive prenatal diagnosis (sex and rhesus) Microarrays technologies for CGH (Comperative Genomic Hybridization) and expression studies Concurrent to the major role that the DMG plays in clinical services, it has also made substantial contributions in several areas of applied research in the field of genetics... There are over 24 public and private institutions currently offering a variety of genetic services in Greece, with ∼17 entries for molecular DNA diagnostic laboratories in the European Directory of DNA Diagnostic Laboratories (EDDNAL) website... Greece has played a pioneer role in the field of hemoglobinopathies, both in the diagnosis, clinical management, therapeutic trials, prenatal diagnosis, and research, while the National Thalassemia Prevention Program has effectively decreased the incidence of thalassemia major and sickle cell (SC) syndromes in Greece... Based on the annual rates over the past 35 years, ∼12,000 couples at risk have had a healthy child... The program has managed to significantly reduce the number of new cases of thalassemia major and direct the available resources toward the optimization of treatment of the surviving patients (Voskaridou et al. )... It is important to separate them from another group, named “Gypsies,” that appeared in Greece in the ninth century through Egypt... Significant difficulties in access to healthcare services by both these minorities, result from the fact that the majority of these populations do not have identity or citizenship documents and they travel frequently... All these groups cooperate with professional medical staff... In 1982, the Hellenic Association of Medical Geneticists was founded and consisted of professionals working in the field of medical genetics... A major aim of the Greek genetics community is to have Clinical Genetics recognized as an independent Medical Specialty in Greece.

No MeSH data available.