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Serum IL-1β and IL-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients.

Wang Y, Hu C, Wang Z, Kong H, Xie W, Wang H - J Biomed Res (2015)

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University , Nanjing, Jiangsu 210029 , China.

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We determined serum IL-1β and IL-18 contents in drug-susceptible tuberculosis (DS-TB) and MDR-TB patients and investigated their relationships with disease severity in tuberculosis... Serum ESR and CRP levels were significantly higher in TB patients than in healthy controls, and in MDR-TB patients than in DS-TB patients... To investigate whether serum IL-1β and IL-18 are related to radiographic severity, we stratified TB patients according to unilateral and bilateral lesions... In DS-TB patients, IL-1β and IL-18 were significantly higher in patients with bilateral lesion subgroup than patients with unilateral lesion... Our results showed that the circulating levels of NLRP3 inflammasome-mediated IL-1β and IL-18 in sera of pulmonary tuberculosis patients, especially in MDR-TB patients, are higher than those in healthy controls and positively correlate with radiographic severity and ESR and CRP... We observed that serum IL-1β is higher in pulmonary tuberculosis patients, especially in MDR-TB patients, than that in healthy controls... The concept that exuberant IL-1β responses are causatively associated with TB progression immunopathology and poor treatment outcome in humans has been receiving more attention... It is reported that higher IL-1β did not suppress the activity of IFN-γ-producing T cells, but correlated with neutrophil accumulation in the lung... It is also documented that high-IL-1β expressing genotype was associated with the severity of pulmonary disease which is in accordance with our results... In our present study, serum IL-1β and IL-18 levels are positively correlated to ESR and CRP in both DS-TB and MDR-TB patients... To our knowledge, this is the first study to examine the relationship between inflammasome-associated cytokines and disease severity markers in pulmonary tuberculosis, especially in MDR-TB patients... Our results demonstrate that elevated levels of serum IL-1β and IL-18 are positively correlated to disease severity.

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Serum IL-1β and IL-18 levels in tuberculosis patients and healthy controls.A: The levels of serum IL-1β was significant higher in TB patients than in healthy controls, and serum IL-1β was higher in MDR-TB than in DS-TB. B: The levels of serum IL-18 was highest in MDR-TB patients, and serum IL-18 was higher in DS-TB patients than in healthy controls. C: In DS-TB patients, the levels of IL-1β and IL-18 were significant higher in patients with bilateral lesion than those in patients with unilateral lesion. D: In MDR-TB patients, the differences of IL-1β or IL-18 between patients with bilateral lesion and unilateral lesion are not statistically significant. * P<0.05, ** P<0.01. DS-TB: drug susceptible tuberculosis; MRD-TB: multidrug-resistant tuberculosis.
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f01: Serum IL-1β and IL-18 levels in tuberculosis patients and healthy controls.A: The levels of serum IL-1β was significant higher in TB patients than in healthy controls, and serum IL-1β was higher in MDR-TB than in DS-TB. B: The levels of serum IL-18 was highest in MDR-TB patients, and serum IL-18 was higher in DS-TB patients than in healthy controls. C: In DS-TB patients, the levels of IL-1β and IL-18 were significant higher in patients with bilateral lesion than those in patients with unilateral lesion. D: In MDR-TB patients, the differences of IL-1β or IL-18 between patients with bilateral lesion and unilateral lesion are not statistically significant. * P<0.05, ** P<0.01. DS-TB: drug susceptible tuberculosis; MRD-TB: multidrug-resistant tuberculosis.

Mentions: ELISA showed (Fig. 1A) that the levels of IL-1β in MDR-TB (7.48±3.58) were significantly higher than that in DS-TB patients (3.07±2.26). Meanwhile, serum IL-18 displayed the same trend, which was higher in MDR-TB patients (131.03±94.92) than DS-TB patients (94.28±57.10) and healthy controls (61.66±24.78) (Fig. 1B). To investigate whether serum IL-1β and IL-18 are related to radiographic severity, we stratified TB patients according to unilateral and bilateral lesions. In DS-TB patients, IL-1β (Fig. 1C) and IL-18 (Fig. 1D) were significantly higher in patients with bilateral lesion subgroup than patients with unilateral lesion. No differences were observed in IL-1β or IL-18 between MDR-TB patients with bilateral and unilateral lesion. Then, we analyzed the relationships between IL-1β/IL-18 and ESR/CRP. As shown in Table 2, there was no obvious correlation between IL-1β/IL-18 and ESR/CRP in healthy controls. However, both in DS-TB and MDR-TB patients, IL-1β positively correlated with ESR and CRP, and IL-18 also positively correlated with ESR and CRP.


Serum IL-1β and IL-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients.

Wang Y, Hu C, Wang Z, Kong H, Xie W, Wang H - J Biomed Res (2015)

Serum IL-1β and IL-18 levels in tuberculosis patients and healthy controls.A: The levels of serum IL-1β was significant higher in TB patients than in healthy controls, and serum IL-1β was higher in MDR-TB than in DS-TB. B: The levels of serum IL-18 was highest in MDR-TB patients, and serum IL-18 was higher in DS-TB patients than in healthy controls. C: In DS-TB patients, the levels of IL-1β and IL-18 were significant higher in patients with bilateral lesion than those in patients with unilateral lesion. D: In MDR-TB patients, the differences of IL-1β or IL-18 between patients with bilateral lesion and unilateral lesion are not statistically significant. * P<0.05, ** P<0.01. DS-TB: drug susceptible tuberculosis; MRD-TB: multidrug-resistant tuberculosis.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4585440&req=5

f01: Serum IL-1β and IL-18 levels in tuberculosis patients and healthy controls.A: The levels of serum IL-1β was significant higher in TB patients than in healthy controls, and serum IL-1β was higher in MDR-TB than in DS-TB. B: The levels of serum IL-18 was highest in MDR-TB patients, and serum IL-18 was higher in DS-TB patients than in healthy controls. C: In DS-TB patients, the levels of IL-1β and IL-18 were significant higher in patients with bilateral lesion than those in patients with unilateral lesion. D: In MDR-TB patients, the differences of IL-1β or IL-18 between patients with bilateral lesion and unilateral lesion are not statistically significant. * P<0.05, ** P<0.01. DS-TB: drug susceptible tuberculosis; MRD-TB: multidrug-resistant tuberculosis.
Mentions: ELISA showed (Fig. 1A) that the levels of IL-1β in MDR-TB (7.48±3.58) were significantly higher than that in DS-TB patients (3.07±2.26). Meanwhile, serum IL-18 displayed the same trend, which was higher in MDR-TB patients (131.03±94.92) than DS-TB patients (94.28±57.10) and healthy controls (61.66±24.78) (Fig. 1B). To investigate whether serum IL-1β and IL-18 are related to radiographic severity, we stratified TB patients according to unilateral and bilateral lesions. In DS-TB patients, IL-1β (Fig. 1C) and IL-18 (Fig. 1D) were significantly higher in patients with bilateral lesion subgroup than patients with unilateral lesion. No differences were observed in IL-1β or IL-18 between MDR-TB patients with bilateral and unilateral lesion. Then, we analyzed the relationships between IL-1β/IL-18 and ESR/CRP. As shown in Table 2, there was no obvious correlation between IL-1β/IL-18 and ESR/CRP in healthy controls. However, both in DS-TB and MDR-TB patients, IL-1β positively correlated with ESR and CRP, and IL-18 also positively correlated with ESR and CRP.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University , Nanjing, Jiangsu 210029 , China.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

We determined serum IL-1β and IL-18 contents in drug-susceptible tuberculosis (DS-TB) and MDR-TB patients and investigated their relationships with disease severity in tuberculosis... Serum ESR and CRP levels were significantly higher in TB patients than in healthy controls, and in MDR-TB patients than in DS-TB patients... To investigate whether serum IL-1β and IL-18 are related to radiographic severity, we stratified TB patients according to unilateral and bilateral lesions... In DS-TB patients, IL-1β and IL-18 were significantly higher in patients with bilateral lesion subgroup than patients with unilateral lesion... Our results showed that the circulating levels of NLRP3 inflammasome-mediated IL-1β and IL-18 in sera of pulmonary tuberculosis patients, especially in MDR-TB patients, are higher than those in healthy controls and positively correlate with radiographic severity and ESR and CRP... We observed that serum IL-1β is higher in pulmonary tuberculosis patients, especially in MDR-TB patients, than that in healthy controls... The concept that exuberant IL-1β responses are causatively associated with TB progression immunopathology and poor treatment outcome in humans has been receiving more attention... It is reported that higher IL-1β did not suppress the activity of IFN-γ-producing T cells, but correlated with neutrophil accumulation in the lung... It is also documented that high-IL-1β expressing genotype was associated with the severity of pulmonary disease which is in accordance with our results... In our present study, serum IL-1β and IL-18 levels are positively correlated to ESR and CRP in both DS-TB and MDR-TB patients... To our knowledge, this is the first study to examine the relationship between inflammasome-associated cytokines and disease severity markers in pulmonary tuberculosis, especially in MDR-TB patients... Our results demonstrate that elevated levels of serum IL-1β and IL-18 are positively correlated to disease severity.

No MeSH data available.


Related in: MedlinePlus