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Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing.

Ge L, Liu S, Xie L, Sang L, Ma C, Li H - J Biomed Res (2015)

Bottom Line: We identified 1,120 significantly up-regulated mRNAs and 178 significantly down-regulated mRNAs in OSCC, compared to normal tissue.This study provides novel insights into OSCC.However, further work is needed to determine if these differentially expressed mRNAs have potential roles as diagnostic biomarkers and candidate therapeutic targets for OSCC.

View Article: PubMed Central - PubMed

Affiliation: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

No MeSH data available.


Related in: MedlinePlus

Expression of MAGEA11 (A) and TCHH (B) in OSCC tissues.A: MRNA transcript levels MAGEA11 and B: TCHH in oral squamous cell carcinoma (OSCC) tissues n  =  15, *P < 0.05 vs. normal controls.
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f01: Expression of MAGEA11 (A) and TCHH (B) in OSCC tissues.A: MRNA transcript levels MAGEA11 and B: TCHH in oral squamous cell carcinoma (OSCC) tissues n  =  15, *P < 0.05 vs. normal controls.

Mentions: To validate the results of deep sequencing, the differential expression of MAGEA11 and TCHH were verified by real-time PCR against 15 paired OSCC and adjacent normal tissues. The results showed that MAGEA11 expression was up-regulated in the tumor samples. The mean expression of MAGEA11 in OSCC tissues (3.0518±1.5700) was significantly higher than in normal tissues (P<0.05; Fig. 1A); TCHH expression was down-regulated in the tumor samples. The mean expression of TCHH in OSCC tissues (0.5388±0.1700) was significantly lower than normal tissues (P<0.05; Fig. 1B).


Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing.

Ge L, Liu S, Xie L, Sang L, Ma C, Li H - J Biomed Res (2015)

Expression of MAGEA11 (A) and TCHH (B) in OSCC tissues.A: MRNA transcript levels MAGEA11 and B: TCHH in oral squamous cell carcinoma (OSCC) tissues n  =  15, *P < 0.05 vs. normal controls.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4585435&req=5

f01: Expression of MAGEA11 (A) and TCHH (B) in OSCC tissues.A: MRNA transcript levels MAGEA11 and B: TCHH in oral squamous cell carcinoma (OSCC) tissues n  =  15, *P < 0.05 vs. normal controls.
Mentions: To validate the results of deep sequencing, the differential expression of MAGEA11 and TCHH were verified by real-time PCR against 15 paired OSCC and adjacent normal tissues. The results showed that MAGEA11 expression was up-regulated in the tumor samples. The mean expression of MAGEA11 in OSCC tissues (3.0518±1.5700) was significantly higher than in normal tissues (P<0.05; Fig. 1A); TCHH expression was down-regulated in the tumor samples. The mean expression of TCHH in OSCC tissues (0.5388±0.1700) was significantly lower than normal tissues (P<0.05; Fig. 1B).

Bottom Line: We identified 1,120 significantly up-regulated mRNAs and 178 significantly down-regulated mRNAs in OSCC, compared to normal tissue.This study provides novel insights into OSCC.However, further work is needed to determine if these differentially expressed mRNAs have potential roles as diagnostic biomarkers and candidate therapeutic targets for OSCC.

View Article: PubMed Central - PubMed

Affiliation: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

No MeSH data available.


Related in: MedlinePlus