Limits...
Internal radiation therapy: a neglected aspect of nuclear medicine in the molecular era.

Lin Y - J Biomed Res (2015)

Bottom Line: With increasing evidence, internal radiation therapy, also known as brachytherapy, has become a neglected aspect of nuclear medicine in the molecular era.Relevant differences and status of their applications in China were mentioned as well.These molecular mediated internal radiation therapies are gaining increasing importance by providing palliative and curative treatments for an increasing number of diseases and becoming one of the important parts of molecular nuclear medicine.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital , Beijing 100730 , China .

ABSTRACT
With increasing evidence, internal radiation therapy, also known as brachytherapy, has become a neglected aspect of nuclear medicine in the molecular era. In this paper, recent developments regarding internal radiation therapy, including developments in radioiodine-131 ((131)I) and thyroid, radioimmunotherapy (RIT) for non-Hodgkin lymphoma (NHL), and radiopharmaceuticals for bone metastases. Relevant differences and status of their applications in China were mentioned as well. These molecular mediated internal radiation therapies are gaining increasing importance by providing palliative and curative treatments for an increasing number of diseases and becoming one of the important parts of molecular nuclear medicine.

No MeSH data available.


Related in: MedlinePlus

The ROC curve of accuracy of ps-Tg and Tg/TSH in distinguishing distant metastases from normal condition.Cited from Lin Y et al. Clin Nucl Med, 2011; 36:1102-1105[14] with permission.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4585428&req=5

f02: The ROC curve of accuracy of ps-Tg and Tg/TSH in distinguishing distant metastases from normal condition.Cited from Lin Y et al. Clin Nucl Med, 2011; 36:1102-1105[14] with permission.

Mentions: The AJCC/International Union against Cancer (AJCC/UICC) classification system, based on pTNM parameters and age in DTC, allows accurate identification of the majority of patients at low-risk of mortality (T1–3, M0 patients) and the higher-risk minority (T4 and M1patients) to determine the appropriate intensity of management strategy and follow-up. For the assessment of DTC recurrence risk, a three level stratification has been formulated by American Thyroid Association (ATA) guidelines (Table 1). However, controversy remains in the definition of “high risk” mentioned in this table, as “thyroiglobulinemia is out of proportion to what is seen on Rx-WBS”. This means that some micrometastatic patients with normal radiologic findings would be identified as high risk only after the first RAI ablation therapy, which has no impact on the dose decision to ablate (Fig. 1). Recent studies suggested that pre-ablative stimulated Tg (ps-Tg) might be considered as a predictive marker for distant metastasis of DTC[14-15], which implies that suspicious high ps-Tg could be regarded as one of the indices for high risk classification even without Rx-WBS (Fig. 2). Moreover, in accordance with the above evidence the recently published “Chinese Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer” emphasized high ps-Tg level as an important pre-assessment marker and regarded it as one of the high recurrence risk indices before RAI treatment and recommendation for high dose 131I.


Internal radiation therapy: a neglected aspect of nuclear medicine in the molecular era.

Lin Y - J Biomed Res (2015)

The ROC curve of accuracy of ps-Tg and Tg/TSH in distinguishing distant metastases from normal condition.Cited from Lin Y et al. Clin Nucl Med, 2011; 36:1102-1105[14] with permission.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4585428&req=5

f02: The ROC curve of accuracy of ps-Tg and Tg/TSH in distinguishing distant metastases from normal condition.Cited from Lin Y et al. Clin Nucl Med, 2011; 36:1102-1105[14] with permission.
Mentions: The AJCC/International Union against Cancer (AJCC/UICC) classification system, based on pTNM parameters and age in DTC, allows accurate identification of the majority of patients at low-risk of mortality (T1–3, M0 patients) and the higher-risk minority (T4 and M1patients) to determine the appropriate intensity of management strategy and follow-up. For the assessment of DTC recurrence risk, a three level stratification has been formulated by American Thyroid Association (ATA) guidelines (Table 1). However, controversy remains in the definition of “high risk” mentioned in this table, as “thyroiglobulinemia is out of proportion to what is seen on Rx-WBS”. This means that some micrometastatic patients with normal radiologic findings would be identified as high risk only after the first RAI ablation therapy, which has no impact on the dose decision to ablate (Fig. 1). Recent studies suggested that pre-ablative stimulated Tg (ps-Tg) might be considered as a predictive marker for distant metastasis of DTC[14-15], which implies that suspicious high ps-Tg could be regarded as one of the indices for high risk classification even without Rx-WBS (Fig. 2). Moreover, in accordance with the above evidence the recently published “Chinese Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer” emphasized high ps-Tg level as an important pre-assessment marker and regarded it as one of the high recurrence risk indices before RAI treatment and recommendation for high dose 131I.

Bottom Line: With increasing evidence, internal radiation therapy, also known as brachytherapy, has become a neglected aspect of nuclear medicine in the molecular era.Relevant differences and status of their applications in China were mentioned as well.These molecular mediated internal radiation therapies are gaining increasing importance by providing palliative and curative treatments for an increasing number of diseases and becoming one of the important parts of molecular nuclear medicine.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Peking Union Medical College Hospital , Beijing 100730 , China .

ABSTRACT
With increasing evidence, internal radiation therapy, also known as brachytherapy, has become a neglected aspect of nuclear medicine in the molecular era. In this paper, recent developments regarding internal radiation therapy, including developments in radioiodine-131 ((131)I) and thyroid, radioimmunotherapy (RIT) for non-Hodgkin lymphoma (NHL), and radiopharmaceuticals for bone metastases. Relevant differences and status of their applications in China were mentioned as well. These molecular mediated internal radiation therapies are gaining increasing importance by providing palliative and curative treatments for an increasing number of diseases and becoming one of the important parts of molecular nuclear medicine.

No MeSH data available.


Related in: MedlinePlus