Limits...
Serum levels of ghrelin and obestatin in children with symptoms suggestive of delayed gastric emptying of unclear etiology.

Saliakellis E, Karatzas N, Iakovou I, Farmaki E, Varlamis G, Fotoulaki M - Ann Gastroenterol (2015 Oct-Dec)

Bottom Line: Preprandial ghrelin and obestatin were higher compared to controls (GHR mean level in patients and controls: 1162 pg/mL and 401 pg/mL respectively; P<0.05; OB mean level in patients and controls: 417 pg/mL and 325 pg/mL respectively; not statistically significant).Postprandial ghrelin was significantly decreased in the subgroup of patients with delayed GET (GHR mean level in children with normal and prolonged GET: 1237 pg/mL and 584 pg/mL respectively; P<0.05).Obestatin and ghrelin were deranged in children with symptoms indicative of delayed GET of unexplained etiology.

View Article: PubMed Central - PubMed

Affiliation: 4 Pediatric Department (Efstratios Saliakellis, Georgios Varlamis, Maria Fotoulaki), Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.

ABSTRACT

Background: Ghrelin and obestatin are peptides of the gut-brain axis affecting appetite and gastrointestinal motility.

Methods: We conducted a cross-sectional, case-control study to determine pre- and postprandial serum levels of total ghrelin and obestatin along with gastric emptying scintigraphy in children with symptoms suggestive of delayed gastric emptying time (GET), not attributable to any identifiable cause.

Results: Twenty children with symptoms suggestive of delayed GET, of whom 9 had delayed GET, and 20 age-matched healthy children were enrolled. Preprandial ghrelin and obestatin were higher compared to controls (GHR mean level in patients and controls: 1162 pg/mL and 401 pg/mL respectively; P<0.05; OB mean level in patients and controls: 417 pg/mL and 325 pg/mL respectively; not statistically significant). Postprandial ghrelin was significantly decreased in the subgroup of patients with delayed GET (GHR mean level in children with normal and prolonged GET: 1237 pg/mL and 584 pg/mL respectively; P<0.05).

Conclusion: Obestatin and ghrelin were deranged in children with symptoms indicative of delayed GET of unexplained etiology. Gastric emptying was prolonged in almost half of the patients thus gastric emptying scintigraphy should be considered in the investigation of children with such symptomatology.

No MeSH data available.


Pre- and postprandial levels of GHR, OB and GHR/OB ratio in patients with normal and delayed gastric emptying time (GET)GHR, ghrelin; OB, obestatin; GHR, OB and GHR/OB values represent mean values
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4585391&req=5

Figure 3: Pre- and postprandial levels of GHR, OB and GHR/OB ratio in patients with normal and delayed gastric emptying time (GET)GHR, ghrelin; OB, obestatin; GHR, OB and GHR/OB values represent mean values

Mentions: The preprandial levels of GHR, OB and the GHR/OB ratio were significantly higher in patients compared to controls (P<0.05) (Fig. 1). Postprandially (patient group) there was a decrease in GHR and an increase in OB levels which were not statistically significant; however the postprandial GHR/OB ratio was found to be significantly lower (Fig. 2). Moreover, the postprandial levels of GHR and the GHR/OB ratio (but not OB) were significantly lower in the patients who had delayed GET (P<0.05) (Fig. 3). Pre- and postprandial levels of GHR, OB were not significantly affected by patient/control characteristics (adjusted effect, regression analysis).


Serum levels of ghrelin and obestatin in children with symptoms suggestive of delayed gastric emptying of unclear etiology.

Saliakellis E, Karatzas N, Iakovou I, Farmaki E, Varlamis G, Fotoulaki M - Ann Gastroenterol (2015 Oct-Dec)

Pre- and postprandial levels of GHR, OB and GHR/OB ratio in patients with normal and delayed gastric emptying time (GET)GHR, ghrelin; OB, obestatin; GHR, OB and GHR/OB values represent mean values
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585391&req=5

Figure 3: Pre- and postprandial levels of GHR, OB and GHR/OB ratio in patients with normal and delayed gastric emptying time (GET)GHR, ghrelin; OB, obestatin; GHR, OB and GHR/OB values represent mean values
Mentions: The preprandial levels of GHR, OB and the GHR/OB ratio were significantly higher in patients compared to controls (P<0.05) (Fig. 1). Postprandially (patient group) there was a decrease in GHR and an increase in OB levels which were not statistically significant; however the postprandial GHR/OB ratio was found to be significantly lower (Fig. 2). Moreover, the postprandial levels of GHR and the GHR/OB ratio (but not OB) were significantly lower in the patients who had delayed GET (P<0.05) (Fig. 3). Pre- and postprandial levels of GHR, OB were not significantly affected by patient/control characteristics (adjusted effect, regression analysis).

Bottom Line: Preprandial ghrelin and obestatin were higher compared to controls (GHR mean level in patients and controls: 1162 pg/mL and 401 pg/mL respectively; P<0.05; OB mean level in patients and controls: 417 pg/mL and 325 pg/mL respectively; not statistically significant).Postprandial ghrelin was significantly decreased in the subgroup of patients with delayed GET (GHR mean level in children with normal and prolonged GET: 1237 pg/mL and 584 pg/mL respectively; P<0.05).Obestatin and ghrelin were deranged in children with symptoms indicative of delayed GET of unexplained etiology.

View Article: PubMed Central - PubMed

Affiliation: 4 Pediatric Department (Efstratios Saliakellis, Georgios Varlamis, Maria Fotoulaki), Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.

ABSTRACT

Background: Ghrelin and obestatin are peptides of the gut-brain axis affecting appetite and gastrointestinal motility.

Methods: We conducted a cross-sectional, case-control study to determine pre- and postprandial serum levels of total ghrelin and obestatin along with gastric emptying scintigraphy in children with symptoms suggestive of delayed gastric emptying time (GET), not attributable to any identifiable cause.

Results: Twenty children with symptoms suggestive of delayed GET, of whom 9 had delayed GET, and 20 age-matched healthy children were enrolled. Preprandial ghrelin and obestatin were higher compared to controls (GHR mean level in patients and controls: 1162 pg/mL and 401 pg/mL respectively; P<0.05; OB mean level in patients and controls: 417 pg/mL and 325 pg/mL respectively; not statistically significant). Postprandial ghrelin was significantly decreased in the subgroup of patients with delayed GET (GHR mean level in children with normal and prolonged GET: 1237 pg/mL and 584 pg/mL respectively; P<0.05).

Conclusion: Obestatin and ghrelin were deranged in children with symptoms indicative of delayed GET of unexplained etiology. Gastric emptying was prolonged in almost half of the patients thus gastric emptying scintigraphy should be considered in the investigation of children with such symptomatology.

No MeSH data available.