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Depression and suicide ideation in chronic hepatitis C patients untreated and treated with interferon: prevalence, prevention, and treatment.

Lucaciu LA, Dumitrascu DL - Ann Gastroenterol (2015 Oct-Dec)

Bottom Line: Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects.Prospective studies reported depression as the most common side effect of interferon, with an incidence peak between weeks 8 and 12 of therapy.Moreover, studies have shown that pretreatment with serotonin reuptake inhibitors is a good strategy for the prevention of interferon-induced depression.

View Article: PubMed Central - PubMed

Affiliation: 2 Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.

ABSTRACT
Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects. We aimed to review the available data on the depression and suicide in CHC patients receiving or not antiviral therapy based on interferon treatment. A PubMed search was performed, identifying relevant papers published between 1991 and January 2015 concerning major depressive disorders and suicidal risk in patients under interferon. A total of 21 relevant papers were retrieved. Prospective studies reported depression as the most common side effect of interferon, with an incidence peak between weeks 8 and 12 of therapy. Suicide risk was analyzed in 7 of the reviewed articles, and case reports of attempted suicide were discussed. Moreover, studies have shown that pretreatment with serotonin reuptake inhibitors is a good strategy for the prevention of interferon-induced depression.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of article selection for the incidence of major depressive disorders
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Figure 1: Flow diagram of article selection for the incidence of major depressive disorders

Mentions: Using PubMed database, 356 articles were identified and titles and abstracts were examined. At this stage 319 were excluded because they did not meet the inclusion criteria. We further excluded 18 case reports and articles not serving the purpose of this paper. After we examined the references of remaining articles we obtained 21 relevant papers (Fig. 1). Selected articles were reviewed and we summarized in (Table 1) the following data: author, year of publication, number of patients included in the study, dose and type of IFN-α, and adjunctive RBV, duration of antiviral treatment, incidence of major depressive disorder and suicide ideation/suicide attempts when reported, scales and methods of assessment of depression, and risk factors for depression.


Depression and suicide ideation in chronic hepatitis C patients untreated and treated with interferon: prevalence, prevention, and treatment.

Lucaciu LA, Dumitrascu DL - Ann Gastroenterol (2015 Oct-Dec)

Flow diagram of article selection for the incidence of major depressive disorders
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585389&req=5

Figure 1: Flow diagram of article selection for the incidence of major depressive disorders
Mentions: Using PubMed database, 356 articles were identified and titles and abstracts were examined. At this stage 319 were excluded because they did not meet the inclusion criteria. We further excluded 18 case reports and articles not serving the purpose of this paper. After we examined the references of remaining articles we obtained 21 relevant papers (Fig. 1). Selected articles were reviewed and we summarized in (Table 1) the following data: author, year of publication, number of patients included in the study, dose and type of IFN-α, and adjunctive RBV, duration of antiviral treatment, incidence of major depressive disorder and suicide ideation/suicide attempts when reported, scales and methods of assessment of depression, and risk factors for depression.

Bottom Line: Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects.Prospective studies reported depression as the most common side effect of interferon, with an incidence peak between weeks 8 and 12 of therapy.Moreover, studies have shown that pretreatment with serotonin reuptake inhibitors is a good strategy for the prevention of interferon-induced depression.

View Article: PubMed Central - PubMed

Affiliation: 2 Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.

ABSTRACT
Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects. We aimed to review the available data on the depression and suicide in CHC patients receiving or not antiviral therapy based on interferon treatment. A PubMed search was performed, identifying relevant papers published between 1991 and January 2015 concerning major depressive disorders and suicidal risk in patients under interferon. A total of 21 relevant papers were retrieved. Prospective studies reported depression as the most common side effect of interferon, with an incidence peak between weeks 8 and 12 of therapy. Suicide risk was analyzed in 7 of the reviewed articles, and case reports of attempted suicide were discussed. Moreover, studies have shown that pretreatment with serotonin reuptake inhibitors is a good strategy for the prevention of interferon-induced depression.

No MeSH data available.


Related in: MedlinePlus