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Study of Serum Levels of Leptin, C-Reactive Protein and Nutritional Status in Hemodialysis Patients.

Montazerifar F, Karajibani M, Hassanpour Z, Pourmofatteh M - Iran Red Crescent Med J (2015)

Bottom Line: Leptin is secreted by adipose tissue and decreases appetite.A significant positive correlation between serum levels of leptin and albumin and BMI was demonstrated.No significant correlations were identified between leptin level, CRP level, and other variables.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Pregnancy Health Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.

ABSTRACT

Background: Leptin is secreted by adipose tissue and decreases appetite. However, the role of leptin in the pathogenesis of hemodialysis (HD)-related malnutrition has not been fully evaluated.

Objectives: The aim of study was to investigate the association between the serum leptin levels, serum C-reactive protein (CRP) levels, and nutritional status in hemodialysis patients.

Patients and methods: This analytical descriptive study included 45 hemodialysis patients and 40 healthy subjects. Biochemical parameters and serum leptin levels were measured. The nutritional status was evaluated using a food frequency questionnaire (FFQ) and the calculation of the body mass index (BMI).

Results: Serum leptin (P < 0.05) and albumin (P < 0.0001) levels and BMI (P < 0.001) of HD patients were significantly lower, while CRP levels were significantly higher than those of controls (P < 0.0001). HD patients consumed the lower daily servings of the food groups compared to the control subjects (P < 0.0001). A significant positive correlation between serum levels of leptin and albumin and BMI was demonstrated. No significant correlations were identified between leptin level, CRP level, and other variables.

Conclusions: The findings suggest that low levels of leptin may be a contributory factor for malnutrition in HD patients. Further studies are required to ascertain the significance of leptin levels in relation to nutritional factors in hemodialysis patients.

No MeSH data available.


Related in: MedlinePlus

Correlation Between Serum Levels of Leptin (ng/mL) and BMI (kg/m²) in HD Patients
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fig22200: Correlation Between Serum Levels of Leptin (ng/mL) and BMI (kg/m²) in HD Patients

Mentions: There was positive correlation between serum levels of leptin and BMI (r = 0.52, P < 0.0001) (Figure 1) and Albumin (r = 0.71, P < 0.05) (Figure 2).


Study of Serum Levels of Leptin, C-Reactive Protein and Nutritional Status in Hemodialysis Patients.

Montazerifar F, Karajibani M, Hassanpour Z, Pourmofatteh M - Iran Red Crescent Med J (2015)

Correlation Between Serum Levels of Leptin (ng/mL) and BMI (kg/m²) in HD Patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585384&req=5

fig22200: Correlation Between Serum Levels of Leptin (ng/mL) and BMI (kg/m²) in HD Patients
Mentions: There was positive correlation between serum levels of leptin and BMI (r = 0.52, P < 0.0001) (Figure 1) and Albumin (r = 0.71, P < 0.05) (Figure 2).

Bottom Line: Leptin is secreted by adipose tissue and decreases appetite.A significant positive correlation between serum levels of leptin and albumin and BMI was demonstrated.No significant correlations were identified between leptin level, CRP level, and other variables.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Pregnancy Health Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.

ABSTRACT

Background: Leptin is secreted by adipose tissue and decreases appetite. However, the role of leptin in the pathogenesis of hemodialysis (HD)-related malnutrition has not been fully evaluated.

Objectives: The aim of study was to investigate the association between the serum leptin levels, serum C-reactive protein (CRP) levels, and nutritional status in hemodialysis patients.

Patients and methods: This analytical descriptive study included 45 hemodialysis patients and 40 healthy subjects. Biochemical parameters and serum leptin levels were measured. The nutritional status was evaluated using a food frequency questionnaire (FFQ) and the calculation of the body mass index (BMI).

Results: Serum leptin (P < 0.05) and albumin (P < 0.0001) levels and BMI (P < 0.001) of HD patients were significantly lower, while CRP levels were significantly higher than those of controls (P < 0.0001). HD patients consumed the lower daily servings of the food groups compared to the control subjects (P < 0.0001). A significant positive correlation between serum levels of leptin and albumin and BMI was demonstrated. No significant correlations were identified between leptin level, CRP level, and other variables.

Conclusions: The findings suggest that low levels of leptin may be a contributory factor for malnutrition in HD patients. Further studies are required to ascertain the significance of leptin levels in relation to nutritional factors in hemodialysis patients.

No MeSH data available.


Related in: MedlinePlus