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Brain lateralization and self-reported symptoms of ADHD in a population sample of adults: a dimensional approach.

Mohamed SM, Börger NA, Geuze RH, van der Meere JJ - Front Psychol (2015)

Bottom Line: For both task conditions, brain lateralization was indexed as the difference in mean reaction time between left and right visual field.These findings from a population sample of adults do not support the dimensionality of lateralized information processing deficit in ADHD symptomatology.However, group comparison analyses showed that subjects with high level of inattention symptoms close to or above the clinical cut-off had a reduced right hemisphere processing in the Shape Physical-Identity condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical and Developmental Neuropsychology, Faculty of Behavioural and Social Sciences, University of Groningen Groningen, Netherlands ; Department of Psychology, Beni-Suef University Beni-Suef, Egypt.

ABSTRACT
Many clinical studies reported a compromised brain lateralization in patients with Attention-Deficit/Hyperactivity Disorder (ADHD) without being conclusive about whether the deficit existed in the left or right hemisphere. It is well-recognized that studying ADHD dimensionally is more controlled for comorbid problems and medication effects, and provides more accurate assessment of the symptoms. Therefore, the present study applied the dimensional approach to test the relationship between brain lateralization and self-reported ADHD symptoms in a population sample. Eighty-five right-handed university students filled in the Conners' Adult ADHD Rating Scales and performed a lateralization reaction time task. The task consists of two matching conditions: one condition requires nominal identification for letters tapping left hemisphere specialization (Letter Name-Identity condition) and the other one requires physical and visuospatial identification for shapes tapping right hemisphere specialization (Shape Physical-Identity condition). The letters or shapes to be matched are presented in left or right visual field of a fixation cross. For both task conditions, brain lateralization was indexed as the difference in mean reaction time between left and right visual field. Linear regression analyses, controlled for mood symptoms reported by a depression, anxiety, and stress scale, showed no relationship between the variables. These findings from a population sample of adults do not support the dimensionality of lateralized information processing deficit in ADHD symptomatology. However, group comparison analyses showed that subjects with high level of inattention symptoms close to or above the clinical cut-off had a reduced right hemisphere processing in the Shape Physical-Identity condition.

No MeSH data available.


Related in: MedlinePlus

The distribution of T-scores on the Conners’ Adult ADHD Rating Scales (CAARS) subscales of inattention, hyperactivity, impulsivity, and Attention-Deficit/Hyperactivity Disorder (ADHD) index.
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Figure 3: The distribution of T-scores on the Conners’ Adult ADHD Rating Scales (CAARS) subscales of inattention, hyperactivity, impulsivity, and Attention-Deficit/Hyperactivity Disorder (ADHD) index.

Mentions: Figure 3 shows the distribution of T-scores on the ADHD index, inattention, hyperactivity, and impulsivity subscales of the CAARS measuring the overall ADHD symptoms and its key domains. The figure indicates that scores on the four domains provide enough variance to test our lateralization hypothesis using the dimensional approach. According to the CAARS manual, the T-score of 65 can be used as a clinical cut-off for all subscales of the CAARS. As can be seen, few students scored above the clinical cut-off. Participants had reliable responses on the CAARS indicated by lower score than eight on the inconsistency index. Table 1 presents the number of subjects within the cut-off scores for the DASS reflecting the degree of severity of mood symptoms relative to the population.


Brain lateralization and self-reported symptoms of ADHD in a population sample of adults: a dimensional approach.

Mohamed SM, Börger NA, Geuze RH, van der Meere JJ - Front Psychol (2015)

The distribution of T-scores on the Conners’ Adult ADHD Rating Scales (CAARS) subscales of inattention, hyperactivity, impulsivity, and Attention-Deficit/Hyperactivity Disorder (ADHD) index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585266&req=5

Figure 3: The distribution of T-scores on the Conners’ Adult ADHD Rating Scales (CAARS) subscales of inattention, hyperactivity, impulsivity, and Attention-Deficit/Hyperactivity Disorder (ADHD) index.
Mentions: Figure 3 shows the distribution of T-scores on the ADHD index, inattention, hyperactivity, and impulsivity subscales of the CAARS measuring the overall ADHD symptoms and its key domains. The figure indicates that scores on the four domains provide enough variance to test our lateralization hypothesis using the dimensional approach. According to the CAARS manual, the T-score of 65 can be used as a clinical cut-off for all subscales of the CAARS. As can be seen, few students scored above the clinical cut-off. Participants had reliable responses on the CAARS indicated by lower score than eight on the inconsistency index. Table 1 presents the number of subjects within the cut-off scores for the DASS reflecting the degree of severity of mood symptoms relative to the population.

Bottom Line: For both task conditions, brain lateralization was indexed as the difference in mean reaction time between left and right visual field.These findings from a population sample of adults do not support the dimensionality of lateralized information processing deficit in ADHD symptomatology.However, group comparison analyses showed that subjects with high level of inattention symptoms close to or above the clinical cut-off had a reduced right hemisphere processing in the Shape Physical-Identity condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical and Developmental Neuropsychology, Faculty of Behavioural and Social Sciences, University of Groningen Groningen, Netherlands ; Department of Psychology, Beni-Suef University Beni-Suef, Egypt.

ABSTRACT
Many clinical studies reported a compromised brain lateralization in patients with Attention-Deficit/Hyperactivity Disorder (ADHD) without being conclusive about whether the deficit existed in the left or right hemisphere. It is well-recognized that studying ADHD dimensionally is more controlled for comorbid problems and medication effects, and provides more accurate assessment of the symptoms. Therefore, the present study applied the dimensional approach to test the relationship between brain lateralization and self-reported ADHD symptoms in a population sample. Eighty-five right-handed university students filled in the Conners' Adult ADHD Rating Scales and performed a lateralization reaction time task. The task consists of two matching conditions: one condition requires nominal identification for letters tapping left hemisphere specialization (Letter Name-Identity condition) and the other one requires physical and visuospatial identification for shapes tapping right hemisphere specialization (Shape Physical-Identity condition). The letters or shapes to be matched are presented in left or right visual field of a fixation cross. For both task conditions, brain lateralization was indexed as the difference in mean reaction time between left and right visual field. Linear regression analyses, controlled for mood symptoms reported by a depression, anxiety, and stress scale, showed no relationship between the variables. These findings from a population sample of adults do not support the dimensionality of lateralized information processing deficit in ADHD symptomatology. However, group comparison analyses showed that subjects with high level of inattention symptoms close to or above the clinical cut-off had a reduced right hemisphere processing in the Shape Physical-Identity condition.

No MeSH data available.


Related in: MedlinePlus