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Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions.

Meena M, Prasad V, Zehra A, Gupta VK, Upadhyay RS - Front Microbiol (2015)

Bottom Line: The metabolic pathways for mannitol biosynthesis and catabolism have been characterized in filamentous fungi by direct diminishment of fructose-6-phosphate into mannitol-1-phosphate including a mannitol-1-phosphate phosphatase catalyst.In plants mannitol is integrated from mannose-6-phosphate to mannitol-1-phosphate, which then dephosphorylates to mannitol.The enzyme mannitol dehydrogenase plays a key role in host-pathogen interactions and must be co-localized with pathogen-secreted mannitol to resist the infection.

View Article: PubMed Central - PubMed

Affiliation: Department of Botany, Banaras Hindu University Varanasi, India.

ABSTRACT
Numerous plants and fungi produce mannitol, which may serve as an osmolyte or metabolic store; furthermore, mannitol also acts as a powerful quencher of reactive oxygen species (ROS). Some phytopathogenic fungi use mannitol to stifle ROS-mediated plant resistance. Mannitol is essential in pathogenesis to balance cell reinforcements produced by both plants and animals. Mannitol likewise serves as a source of reducing power, managing coenzymes, and controlling cytoplasmic pH by going about as a sink or hotspot for protons. The metabolic pathways for mannitol biosynthesis and catabolism have been characterized in filamentous fungi by direct diminishment of fructose-6-phosphate into mannitol-1-phosphate including a mannitol-1-phosphate phosphatase catalyst. In plants mannitol is integrated from mannose-6-phosphate to mannitol-1-phosphate, which then dephosphorylates to mannitol. The enzyme mannitol dehydrogenase plays a key role in host-pathogen interactions and must be co-localized with pathogen-secreted mannitol to resist the infection.

No MeSH data available.


Related in: MedlinePlus

Carbohydrate conversion and mannitol metabolic pathways in fungi.
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Figure 1: Carbohydrate conversion and mannitol metabolic pathways in fungi.

Mentions: The metabolic pathway for mannitol biosynthesis and catabolism is well described in filamentous fungi. Mannitol metabolism in fungus is cyclical process (Hult and Gatenbeck, 1978). Figure 1 depicts the pathways of mannitol synthesis in organisms. In this cycle, mannitol-1-phosphate 5-dehydrogenase (MPD; EC 1.1.1.17) was proposed to decrease Fructose-6-phosphate into mannitol-1-phosphate utilizing the NADH cofactor, processed by dephosphorylation by mannitol-1-phosphate phosphatase (MPP; EC 3.1.3.22), into an inorganic phosphate mannitol. Mannitol would then be oxidized to fructose by MTD (EC 1.1.1.138) utilizing the NADP+ cofactor. At last, fructose would be phosphorylated to fructose-6-phosphate by a hexokinase (HX; EC 2.7.1.1). Dephosphorylation of mannitol-1-phosphate into mannitol by means of MPP was portrayed as being irreversible. Thus, the proposed cycle would run in one direction with MPD as a catabolic enzyme system (Calmes et al., 2013).


Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions.

Meena M, Prasad V, Zehra A, Gupta VK, Upadhyay RS - Front Microbiol (2015)

Carbohydrate conversion and mannitol metabolic pathways in fungi.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585237&req=5

Figure 1: Carbohydrate conversion and mannitol metabolic pathways in fungi.
Mentions: The metabolic pathway for mannitol biosynthesis and catabolism is well described in filamentous fungi. Mannitol metabolism in fungus is cyclical process (Hult and Gatenbeck, 1978). Figure 1 depicts the pathways of mannitol synthesis in organisms. In this cycle, mannitol-1-phosphate 5-dehydrogenase (MPD; EC 1.1.1.17) was proposed to decrease Fructose-6-phosphate into mannitol-1-phosphate utilizing the NADH cofactor, processed by dephosphorylation by mannitol-1-phosphate phosphatase (MPP; EC 3.1.3.22), into an inorganic phosphate mannitol. Mannitol would then be oxidized to fructose by MTD (EC 1.1.1.138) utilizing the NADP+ cofactor. At last, fructose would be phosphorylated to fructose-6-phosphate by a hexokinase (HX; EC 2.7.1.1). Dephosphorylation of mannitol-1-phosphate into mannitol by means of MPP was portrayed as being irreversible. Thus, the proposed cycle would run in one direction with MPD as a catabolic enzyme system (Calmes et al., 2013).

Bottom Line: The metabolic pathways for mannitol biosynthesis and catabolism have been characterized in filamentous fungi by direct diminishment of fructose-6-phosphate into mannitol-1-phosphate including a mannitol-1-phosphate phosphatase catalyst.In plants mannitol is integrated from mannose-6-phosphate to mannitol-1-phosphate, which then dephosphorylates to mannitol.The enzyme mannitol dehydrogenase plays a key role in host-pathogen interactions and must be co-localized with pathogen-secreted mannitol to resist the infection.

View Article: PubMed Central - PubMed

Affiliation: Department of Botany, Banaras Hindu University Varanasi, India.

ABSTRACT
Numerous plants and fungi produce mannitol, which may serve as an osmolyte or metabolic store; furthermore, mannitol also acts as a powerful quencher of reactive oxygen species (ROS). Some phytopathogenic fungi use mannitol to stifle ROS-mediated plant resistance. Mannitol is essential in pathogenesis to balance cell reinforcements produced by both plants and animals. Mannitol likewise serves as a source of reducing power, managing coenzymes, and controlling cytoplasmic pH by going about as a sink or hotspot for protons. The metabolic pathways for mannitol biosynthesis and catabolism have been characterized in filamentous fungi by direct diminishment of fructose-6-phosphate into mannitol-1-phosphate including a mannitol-1-phosphate phosphatase catalyst. In plants mannitol is integrated from mannose-6-phosphate to mannitol-1-phosphate, which then dephosphorylates to mannitol. The enzyme mannitol dehydrogenase plays a key role in host-pathogen interactions and must be co-localized with pathogen-secreted mannitol to resist the infection.

No MeSH data available.


Related in: MedlinePlus