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A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions.

Kumar A, Singh A - Front Pharmacol (2015)

Bottom Line: Increasing evidence has indicated that mitochondrial dysfunction displays significant role in the pathophysiological processes of AD.These mitochondrial-targeting bioenergetics and antioxidant compounds such as coenzyme Q10, idebenone, creatine, mitoQ, mitovitE, MitoTEMPOL, latrepirdine, methylene blue, triterpenoids, SS peptides, curcumin, Ginkgo biloba, and omega-3 polyunsaturated fatty acids with potential efficacy in AD have been identified.Present review is intent to discuss mitochondrial restorative mechanisms of these bioenergetics and antioxidants as a potential alternative drug strategy for effective management of AD.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University , Chandigarh, India.

ABSTRACT
Neurodegenerative diseases are intricate in nature because of the involvement of the multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation and oxidative stress. Alzheimer's disease (AD) is a neurodegenerative disease explained by extracellular amyloid β deposits, intracellular neurofibrillary tangles and mitochondrial dysfunction. Increasing evidence has indicated that mitochondrial dysfunction displays significant role in the pathophysiological processes of AD. Mitochondrial dysfunction involves alterations in mitochondrial respiratory enzyme complex activities, oxidative stress, opening of permeability transition pore, and enhanced apoptosis. Various bioenergetics and antioxidants have been tried or under different investigational phase against AD and other neurodegenerative disorders (Parkinson's disease, Huntington's disease, and Amyotrophic lateral sclerosis) because of their complex and multiple site of action. These mitochondrial-targeting bioenergetics and antioxidant compounds such as coenzyme Q10, idebenone, creatine, mitoQ, mitovitE, MitoTEMPOL, latrepirdine, methylene blue, triterpenoids, SS peptides, curcumin, Ginkgo biloba, and omega-3 polyunsaturated fatty acids with potential efficacy in AD have been identified. Present review is intent to discuss mitochondrial restorative mechanisms of these bioenergetics and antioxidants as a potential alternative drug strategy for effective management of AD.

No MeSH data available.


Related in: MedlinePlus

Various drugs and natural compounds with common potential therapeutic target mitochondria in Alzheimer’s disease.
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Figure 3: Various drugs and natural compounds with common potential therapeutic target mitochondria in Alzheimer’s disease.

Mentions: As previously discussed, alteration in mitochondrial bioenergetic defects, mitochondrial dynamics and mitochondrial trafficking and oxidative stress ROS mediated mitochondria damage plays a key role in AD, PD, HD, and ALS pathogenesis (Reddy and Beal, 2008; Chaturvedi and Beal, 2013). So, strategies that target mitochondrial dysfunction or the agents which enhance mitochondrial bioenergetics and reversed oxidative stress are potentially needed as therapeutics in AD, PD, HD, and ALS. Here we discussed the therapeutic potential of various bioenergetics and antioxidants (Figure 3) which are either have been used or being in different phases of clinical trials.


A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions.

Kumar A, Singh A - Front Pharmacol (2015)

Various drugs and natural compounds with common potential therapeutic target mitochondria in Alzheimer’s disease.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585235&req=5

Figure 3: Various drugs and natural compounds with common potential therapeutic target mitochondria in Alzheimer’s disease.
Mentions: As previously discussed, alteration in mitochondrial bioenergetic defects, mitochondrial dynamics and mitochondrial trafficking and oxidative stress ROS mediated mitochondria damage plays a key role in AD, PD, HD, and ALS pathogenesis (Reddy and Beal, 2008; Chaturvedi and Beal, 2013). So, strategies that target mitochondrial dysfunction or the agents which enhance mitochondrial bioenergetics and reversed oxidative stress are potentially needed as therapeutics in AD, PD, HD, and ALS. Here we discussed the therapeutic potential of various bioenergetics and antioxidants (Figure 3) which are either have been used or being in different phases of clinical trials.

Bottom Line: Increasing evidence has indicated that mitochondrial dysfunction displays significant role in the pathophysiological processes of AD.These mitochondrial-targeting bioenergetics and antioxidant compounds such as coenzyme Q10, idebenone, creatine, mitoQ, mitovitE, MitoTEMPOL, latrepirdine, methylene blue, triterpenoids, SS peptides, curcumin, Ginkgo biloba, and omega-3 polyunsaturated fatty acids with potential efficacy in AD have been identified.Present review is intent to discuss mitochondrial restorative mechanisms of these bioenergetics and antioxidants as a potential alternative drug strategy for effective management of AD.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University , Chandigarh, India.

ABSTRACT
Neurodegenerative diseases are intricate in nature because of the involvement of the multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation and oxidative stress. Alzheimer's disease (AD) is a neurodegenerative disease explained by extracellular amyloid β deposits, intracellular neurofibrillary tangles and mitochondrial dysfunction. Increasing evidence has indicated that mitochondrial dysfunction displays significant role in the pathophysiological processes of AD. Mitochondrial dysfunction involves alterations in mitochondrial respiratory enzyme complex activities, oxidative stress, opening of permeability transition pore, and enhanced apoptosis. Various bioenergetics and antioxidants have been tried or under different investigational phase against AD and other neurodegenerative disorders (Parkinson's disease, Huntington's disease, and Amyotrophic lateral sclerosis) because of their complex and multiple site of action. These mitochondrial-targeting bioenergetics and antioxidant compounds such as coenzyme Q10, idebenone, creatine, mitoQ, mitovitE, MitoTEMPOL, latrepirdine, methylene blue, triterpenoids, SS peptides, curcumin, Ginkgo biloba, and omega-3 polyunsaturated fatty acids with potential efficacy in AD have been identified. Present review is intent to discuss mitochondrial restorative mechanisms of these bioenergetics and antioxidants as a potential alternative drug strategy for effective management of AD.

No MeSH data available.


Related in: MedlinePlus