Limits...
CD74 in Kidney Disease.

Valiño-Rivas L, Baeza-Bermejillo C, Gonzalez-Lafuente L, Sanz AB, Ortiz A, Sanchez-Niño MD - Front Immunol (2015)

Bottom Line: However, CD74 may protect from interstitial kidney fibrosis.Furthermore, CD74 expression by stressed kidney cells raises questions about the kidney safety of cancer therapy strategies delivering lethal immunoconjugates to CD74-expressing cells.Thus, understanding CD74 biology in kidney cells is relevant for kidney therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid , Madrid , Spain.

ABSTRACT
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2). CD74 expression is increased in tubular cells and/or glomerular podocytes and parietal cells in human metabolic nephropathies, polycystic kidney disease, graft rejection and kidney cancer and in experimental diabetic nephropathy and glomerulonephritis. Stressors like abnormal metabolite (glucose, lyso-Gb3) levels and inflammatory cytokines increase kidney cell CD74. MIF activates CD74 to increase inflammatory cytokines in podocytes and tubular cells and proliferation in glomerular parietal epithelial cells and cyst cells. MIF overexpression promotes while MIF targeting protects from experimental glomerular injury and kidney cysts, and interference with MIF/CD74 signaling or CD74 deficiency protected from crescentic glomerulonephritis. However, CD74 may protect from interstitial kidney fibrosis. Furthermore, CD74 expression by stressed kidney cells raises questions about the kidney safety of cancer therapy strategies delivering lethal immunoconjugates to CD74-expressing cells. Thus, understanding CD74 biology in kidney cells is relevant for kidney therapeutics.

No MeSH data available.


Related in: MedlinePlus

CD74 in kidney disease. Studies in CD74-deficient mice with kidney disease have only been published in abstract form. Thus, potential roles of CD74 in kidney disease have been mainly derived from abstracts or studies in which MIF was targeted in cultured cells or experimental animals. A putative effect of CD74 targeting on glomerular injury is only hypothetical and based on studies in which MIF was targeted. In polycystic kidney disease, MIF promotes cystogenesis. The role of CD74 is unclear, but CD74 expression is increased in cystic epithelium.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4585214&req=5

Figure 2: CD74 in kidney disease. Studies in CD74-deficient mice with kidney disease have only been published in abstract form. Thus, potential roles of CD74 in kidney disease have been mainly derived from abstracts or studies in which MIF was targeted in cultured cells or experimental animals. A putative effect of CD74 targeting on glomerular injury is only hypothetical and based on studies in which MIF was targeted. In polycystic kidney disease, MIF promotes cystogenesis. The role of CD74 is unclear, but CD74 expression is increased in cystic epithelium.

Mentions: There is a growing body of evidence linking CD74 to promotion or protection from kidney injury (Figure 2).


CD74 in Kidney Disease.

Valiño-Rivas L, Baeza-Bermejillo C, Gonzalez-Lafuente L, Sanz AB, Ortiz A, Sanchez-Niño MD - Front Immunol (2015)

CD74 in kidney disease. Studies in CD74-deficient mice with kidney disease have only been published in abstract form. Thus, potential roles of CD74 in kidney disease have been mainly derived from abstracts or studies in which MIF was targeted in cultured cells or experimental animals. A putative effect of CD74 targeting on glomerular injury is only hypothetical and based on studies in which MIF was targeted. In polycystic kidney disease, MIF promotes cystogenesis. The role of CD74 is unclear, but CD74 expression is increased in cystic epithelium.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585214&req=5

Figure 2: CD74 in kidney disease. Studies in CD74-deficient mice with kidney disease have only been published in abstract form. Thus, potential roles of CD74 in kidney disease have been mainly derived from abstracts or studies in which MIF was targeted in cultured cells or experimental animals. A putative effect of CD74 targeting on glomerular injury is only hypothetical and based on studies in which MIF was targeted. In polycystic kidney disease, MIF promotes cystogenesis. The role of CD74 is unclear, but CD74 expression is increased in cystic epithelium.
Mentions: There is a growing body of evidence linking CD74 to promotion or protection from kidney injury (Figure 2).

Bottom Line: However, CD74 may protect from interstitial kidney fibrosis.Furthermore, CD74 expression by stressed kidney cells raises questions about the kidney safety of cancer therapy strategies delivering lethal immunoconjugates to CD74-expressing cells.Thus, understanding CD74 biology in kidney cells is relevant for kidney therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid , Madrid , Spain.

ABSTRACT
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2). CD74 expression is increased in tubular cells and/or glomerular podocytes and parietal cells in human metabolic nephropathies, polycystic kidney disease, graft rejection and kidney cancer and in experimental diabetic nephropathy and glomerulonephritis. Stressors like abnormal metabolite (glucose, lyso-Gb3) levels and inflammatory cytokines increase kidney cell CD74. MIF activates CD74 to increase inflammatory cytokines in podocytes and tubular cells and proliferation in glomerular parietal epithelial cells and cyst cells. MIF overexpression promotes while MIF targeting protects from experimental glomerular injury and kidney cysts, and interference with MIF/CD74 signaling or CD74 deficiency protected from crescentic glomerulonephritis. However, CD74 may protect from interstitial kidney fibrosis. Furthermore, CD74 expression by stressed kidney cells raises questions about the kidney safety of cancer therapy strategies delivering lethal immunoconjugates to CD74-expressing cells. Thus, understanding CD74 biology in kidney cells is relevant for kidney therapeutics.

No MeSH data available.


Related in: MedlinePlus