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Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

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bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

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(a) Operation of DNA-basedwalker. (b) AFM images of walker. Reprintedwith permission from ref (1455). Copyright 2010 Nature Publishing Group.
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fig76: (a) Operation of DNA-basedwalker. (b) AFM images of walker. Reprintedwith permission from ref (1455). Copyright 2010 Nature Publishing Group.

Mentions: Stimuli-dependent positional DNAswitches1934,1935 and DNA-based devices performingmultistep organic synthesis whilemigrating along a track have been reported.1447 An in silico “tumbleweed” walker design has also beenproposed.1936 The first DNA-based walkerwas nonautonomous and bipedal and was reported by Sherman and Seeman.1834 High dilution conditions were used to preventthe walker from scrambling betwen different tracks. Sequential additionof two different anchor and fuel strands in an aqueous buffer at 16°C led to the desired walking motion being obtained. The productswere characterized by polyacrylamide gel electrophoresis (PAGE). Theenergy required for directional walking was provided by the additionalbase-pairing in the waste duplex (red toehold region, Figure 74). Mechanistically, this walkeris an inchworm walker because the leading foot remains the same throughoutthe operation. A hand-over-hand DNA walker (the mechanism of operationof kinesin) has been published by Shin and Pierce who used a similardesign.1833 Transport of a cargo over aDNA origami tile and the synthesis of nanoparticle sequences havebeen reported. It used a DNA origami walker unit with four “feet”for controlled movement, and three “arms” for pickingup cargo, each consisting of single strands of DNA (Figures 75 and 76).1455,1937,1938 Fuel strands(Fi) were used to drive the motion and to remove the anchorstrands (Ai). Each station was loaded with a distinct goldnanoparticle cargo and could be switched between states where cargodelivery was possible and where it was not. By manipulating the selectiverelease of each foot from complementary strands of DNA on the DNAtile, the movement of the walker could be controlled. When coupledto the ability of the stations to be switched “on” or“off”, this allowed the formation of eight, differentlycomposed, noncovalently bound products from the full operational sequence.This remarkable level of control on the nanoscale shows that the forcesof Brownian motion can be exploited to great effect in the synthesisof complex supramolecular products. Transportation of a DNA cargoon a DNA origami tile over 16 consecutive steps has also been reported.1939


Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

(a) Operation of DNA-basedwalker. (b) AFM images of walker. Reprintedwith permission from ref (1455). Copyright 2010 Nature Publishing Group.
© Copyright Policy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4585175&req=5

fig76: (a) Operation of DNA-basedwalker. (b) AFM images of walker. Reprintedwith permission from ref (1455). Copyright 2010 Nature Publishing Group.
Mentions: Stimuli-dependent positional DNAswitches1934,1935 and DNA-based devices performingmultistep organic synthesis whilemigrating along a track have been reported.1447 An in silico “tumbleweed” walker design has also beenproposed.1936 The first DNA-based walkerwas nonautonomous and bipedal and was reported by Sherman and Seeman.1834 High dilution conditions were used to preventthe walker from scrambling betwen different tracks. Sequential additionof two different anchor and fuel strands in an aqueous buffer at 16°C led to the desired walking motion being obtained. The productswere characterized by polyacrylamide gel electrophoresis (PAGE). Theenergy required for directional walking was provided by the additionalbase-pairing in the waste duplex (red toehold region, Figure 74). Mechanistically, this walkeris an inchworm walker because the leading foot remains the same throughoutthe operation. A hand-over-hand DNA walker (the mechanism of operationof kinesin) has been published by Shin and Pierce who used a similardesign.1833 Transport of a cargo over aDNA origami tile and the synthesis of nanoparticle sequences havebeen reported. It used a DNA origami walker unit with four “feet”for controlled movement, and three “arms” for pickingup cargo, each consisting of single strands of DNA (Figures 75 and 76).1455,1937,1938 Fuel strands(Fi) were used to drive the motion and to remove the anchorstrands (Ai). Each station was loaded with a distinct goldnanoparticle cargo and could be switched between states where cargodelivery was possible and where it was not. By manipulating the selectiverelease of each foot from complementary strands of DNA on the DNAtile, the movement of the walker could be controlled. When coupledto the ability of the stations to be switched “on” or“off”, this allowed the formation of eight, differentlycomposed, noncovalently bound products from the full operational sequence.This remarkable level of control on the nanoscale shows that the forcesof Brownian motion can be exploited to great effect in the synthesisof complex supramolecular products. Transportation of a DNA cargoon a DNA origami tile over 16 consecutive steps has also been reported.1939

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

No MeSH data available.