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Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

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bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

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Schematicrepresentation of a DNA-based walker and track system.Footholds protrude from the track as single-stranded DNA fragments.Anchor and holding strands enable the walker unit to bind to the footholdsby hybridization. Areas with functional importance are labeled, andcomplementary strands are depicted in the same color for clarity.
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fig74: Schematicrepresentation of a DNA-based walker and track system.Footholds protrude from the track as single-stranded DNA fragments.Anchor and holding strands enable the walker unit to bind to the footholdsby hybridization. Areas with functional importance are labeled, andcomplementary strands are depicted in the same color for clarity.

Mentions: The controlled and predictablestrand displacement of DNA and RNA has been used to construct complexdevices.1369,1869,1922−1932 Among them, walkers represent a major subclass. The basic principlebehind 1-D walking is illustrated in Figure 74. A relatively rigid and stable DNA trackfunctionalized with protruding single-stranded anchorage points (footholds)is typically used.1369,1933 Unlike the direct interactionsof biological walker proteins with polymeric tracks, the footholdsare attached to the track and bind the walker unit by base paring.The walker unit consists of regions with different nucleotide sequences(feet), which are attached to the track via another DNA fragment (theanchor strand), that can hybridize with both the walker and one ofthe footholds leaving a “toehold region” unpaired. Additionof the fuel strand results in base-pairing with an anchor strand,starting from the protruding toehold, and forms a more thermodynamicallyfavored waste duplex. The removal of the anchor strand liberates thefoothold and one foot of the walker. Walking is processive becausethe other foot is still attached to the track by a holding strand,which provides additional stabilization. The walker can be reattachedto the track via the addition of another anchor strand.


Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

Schematicrepresentation of a DNA-based walker and track system.Footholds protrude from the track as single-stranded DNA fragments.Anchor and holding strands enable the walker unit to bind to the footholdsby hybridization. Areas with functional importance are labeled, andcomplementary strands are depicted in the same color for clarity.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585175&req=5

fig74: Schematicrepresentation of a DNA-based walker and track system.Footholds protrude from the track as single-stranded DNA fragments.Anchor and holding strands enable the walker unit to bind to the footholdsby hybridization. Areas with functional importance are labeled, andcomplementary strands are depicted in the same color for clarity.
Mentions: The controlled and predictablestrand displacement of DNA and RNA has been used to construct complexdevices.1369,1869,1922−1932 Among them, walkers represent a major subclass. The basic principlebehind 1-D walking is illustrated in Figure 74. A relatively rigid and stable DNA trackfunctionalized with protruding single-stranded anchorage points (footholds)is typically used.1369,1933 Unlike the direct interactionsof biological walker proteins with polymeric tracks, the footholdsare attached to the track and bind the walker unit by base paring.The walker unit consists of regions with different nucleotide sequences(feet), which are attached to the track via another DNA fragment (theanchor strand), that can hybridize with both the walker and one ofthe footholds leaving a “toehold region” unpaired. Additionof the fuel strand results in base-pairing with an anchor strand,starting from the protruding toehold, and forms a more thermodynamicallyfavored waste duplex. The removal of the anchor strand liberates thefoothold and one foot of the walker. Walking is processive becausethe other foot is still attached to the track by a holding strand,which provides additional stabilization. The walker can be reattachedto the track via the addition of another anchor strand.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

No MeSH data available.