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Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

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bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

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DNA machine reportedby Liu and co-workers, which could be usedto regulate an enzyme cascade reaction. Reprinted with permissionfrom ref (1915). Copyright2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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fig72: DNA machine reportedby Liu and co-workers, which could be usedto regulate an enzyme cascade reaction. Reprinted with permissionfrom ref (1915). Copyright2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Mentions: DNA machines have been used to regulate enzyme cascade reactions.1890,1891 Liu and co-workers reported a machine containing DNA double crossover(DX) motifs, which formed two rigid arms, joined by an immobile four-wayjunction (Figure 72).1915 A DNA motor that could switch betweenstem-loop and double-helix structures, driven by a strand displacementreaction, was incorporated at the center of the machine to cycle betweenopen and closed states. This design amplifies the small motion generatedby the DNA motor into a much greater change in separation betweenthe ends of the two arms where glucose oxidase (GOx) and horseradishperoxidase (HRP) were attached. In this biochemical cascade system,GOx first catalyzed the oxidation of glucose to generate gluconicacid and hydrogen peroxide. Hydrogen peroxide is catalytically reducedby HRP into H2O. At the same time, HRP turns ABTS2– into ABTS–, which allowed the kinetics of theperoxidase to be monitored. HRP has a much higher turnover rate thenGOx, so the distance hydrogen peroxide must diffuse has a crucialinfluence on the rate of reaction. Therefore, when the two enzymesare attached to the two arms, the diffusion distance of hydrogen peroxidecan be changed from 6 to 18 nm by operation of the DNA motor, regulatingthe rate of enzymatic reaction. Sequential addition of fuel and antifuelstrands showed that this regulation was reversible.


Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

DNA machine reportedby Liu and co-workers, which could be usedto regulate an enzyme cascade reaction. Reprinted with permissionfrom ref (1915). Copyright2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585175&req=5

fig72: DNA machine reportedby Liu and co-workers, which could be usedto regulate an enzyme cascade reaction. Reprinted with permissionfrom ref (1915). Copyright2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Mentions: DNA machines have been used to regulate enzyme cascade reactions.1890,1891 Liu and co-workers reported a machine containing DNA double crossover(DX) motifs, which formed two rigid arms, joined by an immobile four-wayjunction (Figure 72).1915 A DNA motor that could switch betweenstem-loop and double-helix structures, driven by a strand displacementreaction, was incorporated at the center of the machine to cycle betweenopen and closed states. This design amplifies the small motion generatedby the DNA motor into a much greater change in separation betweenthe ends of the two arms where glucose oxidase (GOx) and horseradishperoxidase (HRP) were attached. In this biochemical cascade system,GOx first catalyzed the oxidation of glucose to generate gluconicacid and hydrogen peroxide. Hydrogen peroxide is catalytically reducedby HRP into H2O. At the same time, HRP turns ABTS2– into ABTS–, which allowed the kinetics of theperoxidase to be monitored. HRP has a much higher turnover rate thenGOx, so the distance hydrogen peroxide must diffuse has a crucialinfluence on the rate of reaction. Therefore, when the two enzymesare attached to the two arms, the diffusion distance of hydrogen peroxidecan be changed from 6 to 18 nm by operation of the DNA motor, regulatingthe rate of enzymatic reaction. Sequential addition of fuel and antifuelstrands showed that this regulation was reversible.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

No MeSH data available.