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Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

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bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

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(a) Tweezer A: in the closed form the arms are boundto the linker unit (blue) by Hg2+ ions through T–Hg2+–T bonds. To open the molecular tweezer, Hg2+ is sequestered by the addition of cysteine. (b) Tweezer B: in acid the arms form an i-motif, thus releasingthe linker unit, whereas at pH = 7.2, the i-motifis destroyed resulting in the stabilization of the closed structure.(c) Tweezer C: the linker unit can be released by a complementarystrand, the antilinker that opens the tweezers. Reprinted with permissionfrom ref (1914). Copyright2010 American National Academy of Sciences.
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fig71: (a) Tweezer A: in the closed form the arms are boundto the linker unit (blue) by Hg2+ ions through T–Hg2+–T bonds. To open the molecular tweezer, Hg2+ is sequestered by the addition of cysteine. (b) Tweezer B: in acid the arms form an i-motif, thus releasingthe linker unit, whereas at pH = 7.2, the i-motifis destroyed resulting in the stabilization of the closed structure.(c) Tweezer C: the linker unit can be released by a complementarystrand, the antilinker that opens the tweezers. Reprinted with permissionfrom ref (1914). Copyright2010 American National Academy of Sciences.

Mentions: DNA tweezers represent a simple class of DNA machines.1884,1912 They are two-armed constructs bridged by a DNA linker that can undergotransitions between open and closed states in response to externaltriggers such as the addition of single-stranded DNA or metal ions,or a change in pH. Willner et al. reported a biomolecular logic gatebased on three different DNA tweezers A, B, and C. These were activated by different inputs: protons,Hg2+ ions, and nucleic acid strands (Figure 71). The output delivered bythis machine depends both on the inputs provided and its initial internalstate. Depending on the input, there are eight possible configurationsof the three tweezers (open or closed for each). The output couldbe studied by measuring the Förster resonance energy transfer(FRET) between different pairs of fluorophore and quenching moleculesattached to the arms of each of the three tweezers. The linker unitis common to all three tweezers, meaning that tweezers A and B can also be opened by the complementary antilinker.Thus, for any pair of tweezers, there are two different inputs thatcause a change in the state of the device. In total, the device canadopt 16 different states and can furthermore be used as a memorystorage system because each state and output is dependent not onlyon the most recent input but also on past states and inputs.1913,1914


Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

(a) Tweezer A: in the closed form the arms are boundto the linker unit (blue) by Hg2+ ions through T–Hg2+–T bonds. To open the molecular tweezer, Hg2+ is sequestered by the addition of cysteine. (b) Tweezer B: in acid the arms form an i-motif, thus releasingthe linker unit, whereas at pH = 7.2, the i-motifis destroyed resulting in the stabilization of the closed structure.(c) Tweezer C: the linker unit can be released by a complementarystrand, the antilinker that opens the tweezers. Reprinted with permissionfrom ref (1914). Copyright2010 American National Academy of Sciences.
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getmorefigures.php?uid=PMC4585175&req=5

fig71: (a) Tweezer A: in the closed form the arms are boundto the linker unit (blue) by Hg2+ ions through T–Hg2+–T bonds. To open the molecular tweezer, Hg2+ is sequestered by the addition of cysteine. (b) Tweezer B: in acid the arms form an i-motif, thus releasingthe linker unit, whereas at pH = 7.2, the i-motifis destroyed resulting in the stabilization of the closed structure.(c) Tweezer C: the linker unit can be released by a complementarystrand, the antilinker that opens the tweezers. Reprinted with permissionfrom ref (1914). Copyright2010 American National Academy of Sciences.
Mentions: DNA tweezers represent a simple class of DNA machines.1884,1912 They are two-armed constructs bridged by a DNA linker that can undergotransitions between open and closed states in response to externaltriggers such as the addition of single-stranded DNA or metal ions,or a change in pH. Willner et al. reported a biomolecular logic gatebased on three different DNA tweezers A, B, and C. These were activated by different inputs: protons,Hg2+ ions, and nucleic acid strands (Figure 71). The output delivered bythis machine depends both on the inputs provided and its initial internalstate. Depending on the input, there are eight possible configurationsof the three tweezers (open or closed for each). The output couldbe studied by measuring the Förster resonance energy transfer(FRET) between different pairs of fluorophore and quenching moleculesattached to the arms of each of the three tweezers. The linker unitis common to all three tweezers, meaning that tweezers A and B can also be opened by the complementary antilinker.Thus, for any pair of tweezers, there are two different inputs thatcause a change in the state of the device. In total, the device canadopt 16 different states and can furthermore be used as a memorystorage system because each state and output is dependent not onlyon the most recent input but also on past states and inputs.1913,1914

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

No MeSH data available.


Related in: MedlinePlus