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Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

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Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

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bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

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(a) The structure and operation of walker 125, whichuses dynamic imine exchange chemistry. Amine footholds are highlightedin blue and red. Each molecule is labeled with one or two numbersin parentheses indicating the amine footholds to which the walkeris attached (foothold amines are assigned with numbers starting fromthe left). (b) 1H NMR spectra of indicated protons in CDCl3. H7 corresponds to a side product in which thewalker is detached from the track. Reprinted with permission fromref (1395). Copyright2012 American Chemical Society.
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fig49: (a) The structure and operation of walker 125, whichuses dynamic imine exchange chemistry. Amine footholds are highlightedin blue and red. Each molecule is labeled with one or two numbersin parentheses indicating the amine footholds to which the walkeris attached (foothold amines are assigned with numbers starting fromthe left). (b) 1H NMR spectra of indicated protons in CDCl3. H7 corresponds to a side product in which thewalker is detached from the track. Reprinted with permission fromref (1395). Copyright2012 American Chemical Society.

Mentions: Reversible and processive migration of a Michaelacceptor along a protein was reported in 1979 by Lawton et al.1394 More recently, Lehn et al. used dynamic imineexchange to transport a salicylidene walker 125 alongan amine bearing track (Figure 49).1395 Deprotection of theamine at one side of the track using methoxyamine initiated the dynamicexchange reactions. The speed of exchange was shown to be modulatedwhen substitution, composition of the solvent, or temperature wasaltered. 1H NMR analysis in CDCl3 proved thatthe relative intensity of a characteristic signal corresponding tothe transported walker (H6) increased gradually and in2 days the transported walker was the dominant product in solution.Recently, the same group reported a modified version of their walkerwith thermodynamic sinks at each end of the track. These trap thestochastic walker at one end in acid as an imine, or as a lactoneat the other end under basic conditions.1396


Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

(a) The structure and operation of walker 125, whichuses dynamic imine exchange chemistry. Amine footholds are highlightedin blue and red. Each molecule is labeled with one or two numbersin parentheses indicating the amine footholds to which the walkeris attached (foothold amines are assigned with numbers starting fromthe left). (b) 1H NMR spectra of indicated protons in CDCl3. H7 corresponds to a side product in which thewalker is detached from the track. Reprinted with permission fromref (1395). Copyright2012 American Chemical Society.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4585175&req=5

fig49: (a) The structure and operation of walker 125, whichuses dynamic imine exchange chemistry. Amine footholds are highlightedin blue and red. Each molecule is labeled with one or two numbersin parentheses indicating the amine footholds to which the walkeris attached (foothold amines are assigned with numbers starting fromthe left). (b) 1H NMR spectra of indicated protons in CDCl3. H7 corresponds to a side product in which thewalker is detached from the track. Reprinted with permission fromref (1395). Copyright2012 American Chemical Society.
Mentions: Reversible and processive migration of a Michaelacceptor along a protein was reported in 1979 by Lawton et al.1394 More recently, Lehn et al. used dynamic imineexchange to transport a salicylidene walker 125 alongan amine bearing track (Figure 49).1395 Deprotection of theamine at one side of the track using methoxyamine initiated the dynamicexchange reactions. The speed of exchange was shown to be modulatedwhen substitution, composition of the solvent, or temperature wasaltered. 1H NMR analysis in CDCl3 proved thatthe relative intensity of a characteristic signal corresponding tothe transported walker (H6) increased gradually and in2 days the transported walker was the dominant product in solution.Recently, the same group reported a modified version of their walkerwith thermodynamic sinks at each end of the track. These trap thestochastic walker at one end in acid as an imine, or as a lactoneat the other end under basic conditions.1396

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

No MeSH data available.